ES418113A1 - Piperazino-pyrimidines process for their preparation and use - Google Patents

Piperazino-pyrimidines process for their preparation and use

Info

Publication number
ES418113A1
ES418113A1 ES418113A ES418113A ES418113A1 ES 418113 A1 ES418113 A1 ES 418113A1 ES 418113 A ES418113 A ES 418113A ES 418113 A ES418113 A ES 418113A ES 418113 A1 ES418113 A1 ES 418113A1
Authority
ES
Spain
Prior art keywords
formula
pyrimidine
group
preparation
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES418113A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Produits Chimiques Ugine Kuhlmann
Ugine Kuhlmann SA
Original Assignee
Produits Chimiques Ugine Kuhlmann
Ugine Kuhlmann SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Produits Chimiques Ugine Kuhlmann, Ugine Kuhlmann SA filed Critical Produits Chimiques Ugine Kuhlmann
Publication of ES418113A1 publication Critical patent/ES418113A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A procedure for the preparation of pyrimidine derivatives of the general formula: **(See formula)** where R represents a methyl or methylthio group, X represents a halogen atom or an alkoxy group of 1 to 5 carbon atoms, Y represents an optionally substituted acylamino or amino group, Z represents a hydrogen atom or a methyl, ethyl group, hydroxyethyl or phenyl, except for 2-methylamino-4-N-methylpiperazino-5-methylthio-6-chloro-pyrimidine, whose procedure is characterized by reacting a 4,6-dichloro-pyrimidine of formula: **(See formula)** with a piperazine of the formula: **(See formula)** in an anhydrous medium, in the presence of an acid accepting agent, at a temperature comprised between 40 and 120ºC and, if necessary, replace the chlorine atom of the product obtained with an alkoxy group. (Machine-translation by Google Translate, not legally binding)
ES418113A 1973-07-06 1973-08-22 Piperazino-pyrimidines process for their preparation and use Expired ES418113A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7324874A FR2257294B1 (en) 1973-07-06 1973-07-06

Publications (1)

Publication Number Publication Date
ES418113A1 true ES418113A1 (en) 1976-03-16

Family

ID=9122191

Family Applications (1)

Application Number Title Priority Date Filing Date
ES418113A Expired ES418113A1 (en) 1973-07-06 1973-08-22 Piperazino-pyrimidines process for their preparation and use

Country Status (10)

Country Link
JP (1) JPS5849548B2 (en)
BE (1) BE803803A (en)
CH (1) CH582171A5 (en)
DE (1) DE2342880A1 (en)
ES (1) ES418113A1 (en)
FR (1) FR2257294B1 (en)
GB (1) GB1434544A (en)
LU (1) LU68263A1 (en)
MX (1) MX2978E (en)
NO (1) NO137205C (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605319A (en) * 1975-05-23 1976-11-25 Mar Pha Etu Expl Marques PROCESS FOR PREPARING A MEDICINAL PRODUCT, SUCH MEDICINAL PRODUCT AND PROCESS FOR PREPARING SUITABLE MEDICINAL COMPOUNDS.
FR2417507A2 (en) * 1977-07-28 1979-09-14 Ugine Kuhlmann DIAMINO-2,4 (OR -4,6) METHYLTHIO-5 PYRIMIDINES HERBICIDES
JPS54159877A (en) * 1978-06-07 1979-12-18 Matsushita Electronics Corp Detection method for semiconductor substrate position and break
FR2503162A1 (en) * 1981-04-07 1982-10-08 Pharmindustrie NOVEL PIPERAZINO-2 PYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS OR AS INTERMEDIATES FOR THE PRODUCTION OF MEDICAMENTS
JPS6177335A (en) * 1984-09-25 1986-04-19 Kazumichi Kimura Defective mark detector for semiconductor pellet
IT1191845B (en) * 1986-01-20 1988-03-23 Dompe Farmaceutici Spa PHARMACOLOGICALLY ACTIVE ALCHYLOLS
JPH02114936U (en) * 1989-03-03 1990-09-14

Also Published As

Publication number Publication date
LU68263A1 (en) 1973-10-24
MX2978E (en) 1980-01-17
NO326073L (en) 1975-02-03
FR2257294B1 (en) 1977-07-01
DE2342880A1 (en) 1975-01-30
NO137205C (en) 1978-01-18
NO137205B (en) 1977-10-10
BE803803A (en) 1974-02-20
GB1434544A (en) 1976-05-05
JPS5025578A (en) 1975-03-18
CH582171A5 (en) 1976-11-30
FR2257294A1 (en) 1975-08-08
JPS5849548B2 (en) 1983-11-05

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