ES448721A1 - A procedure for the production of antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the production of antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES448721A1 ES448721A1 ES448721A ES448721A ES448721A1 ES 448721 A1 ES448721 A1 ES 448721A1 ES 448721 A ES448721 A ES 448721A ES 448721 A ES448721 A ES 448721A ES 448721 A1 ES448721 A1 ES 448721A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- hydrogen
- piperidinyl
- see formula
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
A process for the production of antibacterial amide compounds of the formula **(See formula)** and of the formula **(See formula)** and you leave them; characterized in that a compound of the formula **(See formula)** or a salt or reactive derivative thereof is reacted with a compound of the formula **(See formula)** or the formula **(See formula)** or a salt or a silylated derivative thereof; and the product is isolated in the form of the free amino acid or in the form of salt; where R is hydrogen or methyl; R1 and R2 are hydrogen, straight or branched chain lower alcohol groups having one to six carbon atoms, or R1R2N considered as a whole is nitro, 4-R5-1-piperazinyl, 4-methyl-1-homopiperazinyl, 1-pyrrolidinyl, morpholinyl, l-piperidinyl, 4- (1-pyrrolidinyl) piperidinyl, or 4- (1-piperidinyl) piperidinyl, where R5 is a lower alcohol group having one to six carbon atoms, cyclohexyl, benzyl, phenyl or halophenyl; R3 is phenyl, p-hydroxyphenyl, 2-thienyl or cyclohexa-1,4-dien-1-yl; R4 is hydrogen, acetoxy, (5-methyl1,3,4-thiadiazol-2-yl) thio, (2-pyrimidinyl) thio or 1-pyridyl, with the proviso that when R4 is 1-pyridyl, CO2H is - CO2-; X is hydrogen, chlorine, or bromine; and Y is hydrogen or bromine. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43476374A | 1974-01-21 | 1974-01-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES448721A1 true ES448721A1 (en) | 1977-07-16 |
Family
ID=23725581
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES433981A Expired ES433981A1 (en) | 1974-01-21 | 1975-01-20 | Procedure to produce antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding) |
ES448721A Expired ES448721A1 (en) | 1974-01-21 | 1976-06-10 | A procedure for the production of antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES433981A Expired ES433981A1 (en) | 1974-01-21 | 1975-01-20 | Procedure to produce antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding) |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS50106995A (en) |
AT (1) | AT336788B (en) |
AU (1) | AU7767675A (en) |
BE (1) | BE824579A (en) |
DE (1) | DE2502119A1 (en) |
DK (1) | DK14975A (en) |
ES (2) | ES433981A1 (en) |
FR (1) | FR2263764B1 (en) |
GB (1) | GB1464525A (en) |
IL (1) | IL46478A0 (en) |
NL (1) | NL7500645A (en) |
SE (1) | SE7500570L (en) |
ZA (1) | ZA7546B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5344585A (en) * | 1976-10-02 | 1978-04-21 | Meiji Seika Kaisha Ltd | Cephalosporin derivatives and their preparation |
US4101661A (en) * | 1977-06-03 | 1978-07-18 | Warner-Lambert | Novel antibacterial amide compounds and process means for producing the same |
US4311698A (en) * | 1979-03-12 | 1982-01-19 | Haskell Theodore H | Aminoacid derivatives of cephalosporin compounds |
JPS5651488A (en) * | 1979-10-02 | 1981-05-09 | Meiji Seika Kaisha Ltd | Penicillin derivative and its preparation |
SE9904724D0 (en) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
EP1828156A2 (en) * | 2004-12-13 | 2007-09-05 | Arena Pharmaceuticals, Inc. | N-biaryl and n-arylheteroaryl piperazine derivatives as modulators of the 5ht2c receptor useful for the treatment of disorders related thereto |
SE529246C2 (en) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | New disubstituted phenyl-piperidines as modulators of dopamine neurotransmission |
KR20150013476A (en) | 2012-04-04 | 2015-02-05 | 아이백스 인터내셔널 게엠베하 | Pharmaceutical compositions for combination therapy |
-
1975
- 1975-01-02 ZA ZA00750046A patent/ZA7546B/en unknown
- 1975-01-20 SE SE7500570A patent/SE7500570L/xx unknown
- 1975-01-20 DE DE19752502119 patent/DE2502119A1/en active Pending
- 1975-01-20 BE BE152538A patent/BE824579A/en unknown
- 1975-01-20 ES ES433981A patent/ES433981A1/en not_active Expired
- 1975-01-20 NL NL7500645A patent/NL7500645A/en unknown
- 1975-01-20 DK DK14975*#A patent/DK14975A/da unknown
- 1975-01-20 AT AT36475A patent/AT336788B/en not_active IP Right Cessation
- 1975-01-20 GB GB246175A patent/GB1464525A/en not_active Expired
- 1975-01-20 FR FR7501608A patent/FR2263764B1/fr not_active Expired
- 1975-01-20 JP JP50008596A patent/JPS50106995A/ja active Pending
- 1975-01-21 IL IL46478A patent/IL46478A0/en unknown
- 1975-01-29 AU AU77676/75A patent/AU7767675A/en not_active Expired
-
1976
- 1976-06-10 ES ES448721A patent/ES448721A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE2502119A1 (en) | 1975-07-24 |
FR2263764A1 (en) | 1975-10-10 |
BE824579A (en) | 1975-05-15 |
FR2263764B1 (en) | 1978-07-07 |
DK14975A (en) | 1975-09-22 |
ZA7546B (en) | 1976-08-25 |
NL7500645A (en) | 1975-07-23 |
ES433981A1 (en) | 1977-03-01 |
IL46478A0 (en) | 1975-04-25 |
JPS50106995A (en) | 1975-08-22 |
AU7767675A (en) | 1976-07-29 |
ATA36475A (en) | 1976-09-15 |
GB1464525A (en) | 1977-02-16 |
SE7500570L (en) | 1975-07-22 |
AT336788B (en) | 1977-05-25 |
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