ES448721A1 - A procedure for the production of antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the production of antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES448721A1
ES448721A1 ES448721A ES448721A ES448721A1 ES 448721 A1 ES448721 A1 ES 448721A1 ES 448721 A ES448721 A ES 448721A ES 448721 A ES448721 A ES 448721A ES 448721 A1 ES448721 A1 ES 448721A1
Authority
ES
Spain
Prior art keywords
formula
hydrogen
piperidinyl
see formula
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES448721A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of ES448721A1 publication Critical patent/ES448721A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A process for the production of antibacterial amide compounds of the formula **(See formula)** and of the formula **(See formula)** and you leave them; characterized in that a compound of the formula **(See formula)** or a salt or reactive derivative thereof is reacted with a compound of the formula **(See formula)** or the formula **(See formula)** or a salt or a silylated derivative thereof; and the product is isolated in the form of the free amino acid or in the form of salt; where R is hydrogen or methyl; R1 and R2 are hydrogen, straight or branched chain lower alcohol groups having one to six carbon atoms, or R1R2N considered as a whole is nitro, 4-R5-1-piperazinyl, 4-methyl-1-homopiperazinyl, 1-pyrrolidinyl, morpholinyl, l-piperidinyl, 4- (1-pyrrolidinyl) piperidinyl, or 4- (1-piperidinyl) piperidinyl, where R5 is a lower alcohol group having one to six carbon atoms, cyclohexyl, benzyl, phenyl or halophenyl; R3 is phenyl, p-hydroxyphenyl, 2-thienyl or cyclohexa-1,4-dien-1-yl; R4 is hydrogen, acetoxy, (5-methyl1,3,4-thiadiazol-2-yl) thio, (2-pyrimidinyl) thio or 1-pyridyl, with the proviso that when R4 is 1-pyridyl, CO2H is - CO2-; X is hydrogen, chlorine, or bromine; and Y is hydrogen or bromine. (Machine-translation by Google Translate, not legally binding)
ES448721A 1974-01-21 1976-06-10 A procedure for the production of antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding) Expired ES448721A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43476374A 1974-01-21 1974-01-21

Publications (1)

Publication Number Publication Date
ES448721A1 true ES448721A1 (en) 1977-07-16

Family

ID=23725581

Family Applications (2)

Application Number Title Priority Date Filing Date
ES433981A Expired ES433981A1 (en) 1974-01-21 1975-01-20 Procedure to produce antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding)
ES448721A Expired ES448721A1 (en) 1974-01-21 1976-06-10 A procedure for the production of antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES433981A Expired ES433981A1 (en) 1974-01-21 1975-01-20 Procedure to produce antibacterial amidic compounds. (Machine-translation by Google Translate, not legally binding)

Country Status (13)

Country Link
JP (1) JPS50106995A (en)
AT (1) AT336788B (en)
AU (1) AU7767675A (en)
BE (1) BE824579A (en)
DE (1) DE2502119A1 (en)
DK (1) DK14975A (en)
ES (2) ES433981A1 (en)
FR (1) FR2263764B1 (en)
GB (1) GB1464525A (en)
IL (1) IL46478A0 (en)
NL (1) NL7500645A (en)
SE (1) SE7500570L (en)
ZA (1) ZA7546B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5344585A (en) * 1976-10-02 1978-04-21 Meiji Seika Kaisha Ltd Cephalosporin derivatives and their preparation
US4101661A (en) * 1977-06-03 1978-07-18 Warner-Lambert Novel antibacterial amide compounds and process means for producing the same
US4311698A (en) * 1979-03-12 1982-01-19 Haskell Theodore H Aminoacid derivatives of cephalosporin compounds
JPS5651488A (en) * 1979-10-02 1981-05-09 Meiji Seika Kaisha Ltd Penicillin derivative and its preparation
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
SE9904724D0 (en) * 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
AU2005316825A1 (en) * 2004-12-13 2006-06-22 Arena Pharmaceuticals, Inc. N-biaryl and N-arylheteroaryl piperazine derivatives as modulators of the 5HT2C receptor useful for the treatment of disorders related thereto
SE529246C2 (en) 2005-10-13 2007-06-12 Neurosearch Sweden Ab New disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
JP6177875B2 (en) 2012-04-04 2017-08-09 テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーＴｅｖａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ Pharmaceutical composition for combination therapy

Also Published As

Publication number Publication date
FR2263764B1 (en) 1978-07-07
BE824579A (en) 1975-05-15
SE7500570L (en) 1975-07-22
DK14975A (en) 1975-09-22
ES433981A1 (en) 1977-03-01
NL7500645A (en) 1975-07-23
JPS50106995A (en) 1975-08-22
GB1464525A (en) 1977-02-16
AU7767675A (en) 1976-07-29
ATA36475A (en) 1976-09-15
DE2502119A1 (en) 1975-07-24
FR2263764A1 (en) 1975-10-10
ZA7546B (en) 1976-08-25
IL46478A0 (en) 1975-04-25
AT336788B (en) 1977-05-25

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