ES458164A1 - 1,4-disubstituted 4-imidazolin-2-ones,1,4-disubstituted imidazolin-2-ones and 1,4-disubstituted imidazolidin-2-thiones and their use in non-asymmetric synthesis of tetramisole levamisole and their derivatives - Google Patents

1,4-disubstituted 4-imidazolin-2-ones,1,4-disubstituted imidazolin-2-ones and 1,4-disubstituted imidazolidin-2-thiones and their use in non-asymmetric synthesis of tetramisole levamisole and their derivatives

Info

Publication number
ES458164A1
ES458164A1 ES458164A ES458164A ES458164A1 ES 458164 A1 ES458164 A1 ES 458164A1 ES 458164 A ES458164 A ES 458164A ES 458164 A ES458164 A ES 458164A ES 458164 A1 ES458164 A1 ES 458164A1
Authority
ES
Spain
Prior art keywords
disubstituted
ones
imidazolin
derivatives
tetramisole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES458164A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/739,924 external-priority patent/US4090025A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES458164A1 publication Critical patent/ES458164A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing substituted imidazolidine derivatives of formula HY wherein R2 is phenyl or phenyl substituted with up to two groups consisting of C1-C6 alkyl, halo or trifluoromethyl; and Y is a pharmaceutically acceptable anion, characterized by heating a substituted imidazolidinethione of the formula: *** See image 01 *** See image 02 (Machine-translation by Google Translate, not legally binding)
ES458164A 1976-04-26 1977-04-26 1,4-disubstituted 4-imidazolin-2-ones,1,4-disubstituted imidazolin-2-ones and 1,4-disubstituted imidazolidin-2-thiones and their use in non-asymmetric synthesis of tetramisole levamisole and their derivatives Expired ES458164A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68031176A 1976-04-26 1976-04-26
US05/739,924 US4090025A (en) 1976-04-26 1976-11-08 Intermediates for synthesis of tetramisole, levamisole and their derivatives

Publications (1)

Publication Number Publication Date
ES458164A1 true ES458164A1 (en) 1978-08-16

Family

ID=27102431

Family Applications (1)

Application Number Title Priority Date Filing Date
ES458164A Expired ES458164A1 (en) 1976-04-26 1977-04-26 1,4-disubstituted 4-imidazolin-2-ones,1,4-disubstituted imidazolin-2-ones and 1,4-disubstituted imidazolidin-2-thiones and their use in non-asymmetric synthesis of tetramisole levamisole and their derivatives

Country Status (14)

Country Link
JP (1) JPS52142067A (en)
AU (1) AU2341277A (en)
DD (1) DD131175A5 (en)
DE (1) DE2718059A1 (en)
DK (1) DK181177A (en)
ES (1) ES458164A1 (en)
FR (1) FR2370735A1 (en)
GB (2) GB1579861A (en)
IL (1) IL51654A0 (en)
IT (1) IT1086883B (en)
NL (1) NL7704424A (en)
NO (1) NO771422L (en)
NZ (1) NZ183622A (en)
SE (1) SE7704745L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51639A0 (en) * 1976-04-26 1977-05-31 American Cyanamid Co New synthesis of tetramisole levamisole and their derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3726894A (en) * 1971-06-24 1973-04-10 American Cyanamid Co The compound 1-(2-hydroxyethyl)-4-phenyl-2-imidazolidinethione
GB1435900A (en) * 1972-10-04 1976-05-19 Agfa Gevaert Method for the preparation of planographic printing plates
FR2258379A1 (en) * 1974-01-21 1975-08-18 Aries Robert Imidazo thiazolidine anthelmintics - prepd from an ethylene thiourea and a haloethanol, halogenation and cyclisation

Also Published As

Publication number Publication date
NZ183622A (en) 1980-04-28
NO771422L (en) 1977-10-27
NL7704424A (en) 1977-10-28
JPS52142067A (en) 1977-11-26
DK181177A (en) 1977-10-27
DE2718059A1 (en) 1977-11-10
AU2341277A (en) 1978-09-21
DD131175A5 (en) 1978-06-07
IT1086883B (en) 1985-05-31
FR2370735A1 (en) 1978-06-09
IL51654A0 (en) 1977-05-31
GB1579862A (en) 1980-11-26
GB1579861A (en) 1980-11-26
SE7704745L (en) 1977-10-27

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