IE37043B1 - Novel pyrimidinones - Google Patents
Novel pyrimidinonesInfo
- Publication number
- IE37043B1 IE37043B1 IE1398/72A IE139872A IE37043B1 IE 37043 B1 IE37043 B1 IE 37043B1 IE 1398/72 A IE1398/72 A IE 1398/72A IE 139872 A IE139872 A IE 139872A IE 37043 B1 IE37043 B1 IE 37043B1
- Authority
- IE
- Ireland
- Prior art keywords
- methyl
- prepared
- hydrogen
- reacting
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1377308 Substituted 5-phenoxy and 5-thiophenoxy-2-(1H)-pyrimidinones PFIZER Inc 18 Feb 1972 [29 Oct 1971] 7748/72 Heading C2C Novel compounds of the Formula I: wherein R is hydrogen or methyl, R 1 is oxygen or sulphur, R 2 is hydrogen, halogen or methyl and R 3 is hydrogen, methyl, chloro or trifluoromethyl and pharmaceutically acceptable salts thereof may be prepared by reacting a compound wherein R 6 and R 7 are C 1-3 alkyl groups, with a reagent prepared from ethanol, sodium and urea and if necessary reacting the product with an alkali metal or alkaline earth metal salt and hot methyl iodide to introduce the methyl group at R. 2 - (p - Chlorophenoxy) - 3 - dimethylaminoacrolein may be prepared by reacting potassium p-chlorophenolate, prepared in situ, with chloroacetaldehyde diethylacetal to yield pchlorophenoxyacetaldehyde diethyl acetal which on reaction with dimethyl formamide in the presence of phosphorus oxychloride cyclizes to the required intermediate. Pharmaceutical compositions of the compound I with the usual excipients show bronchodilatory activity and inhibit gastric acid secretion when administered orally, parenterally or by inhalation.
[GB1377308A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19400671A | 1971-10-29 | 1971-10-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37043L IE37043L (en) | 1973-04-29 |
| IE37043B1 true IE37043B1 (en) | 1977-04-27 |
Family
ID=22715935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1398/72A IE37043B1 (en) | 1971-10-29 | 1972-10-16 | Novel pyrimidinones |
Country Status (25)
| Country | Link |
|---|---|
| JP (2) | JPS5337870B2 (en) |
| AR (2) | AR198798A1 (en) |
| AT (2) | AT321308B (en) |
| AU (1) | AU467600B2 (en) |
| BE (1) | BE790125A (en) |
| CA (1) | CA980778A (en) |
| CH (2) | CH555832A (en) |
| DE (3) | DE2248741C3 (en) |
| DK (1) | DK131465B (en) |
| EG (1) | EG11013A (en) |
| ES (2) | ES407730A1 (en) |
| FI (1) | FI55503C (en) |
| FR (1) | FR2157865B1 (en) |
| GB (2) | GB1377308A (en) |
| IE (1) | IE37043B1 (en) |
| IL (2) | IL40458A (en) |
| LU (1) | LU66304A1 (en) |
| NL (1) | NL166470C (en) |
| NO (1) | NO136574C (en) |
| PH (2) | PH10129A (en) |
| PL (2) | PL89852B1 (en) |
| SE (2) | SE393376B (en) |
| SU (2) | SU498908A3 (en) |
| YU (2) | YU35125B (en) |
| ZA (1) | ZA727362B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55151912U (en) * | 1979-04-17 | 1980-11-01 | ||
| JPS5752409Y2 (en) * | 1979-11-05 | 1982-11-15 | ||
| DE3222914A1 (en) * | 1982-06-18 | 1983-12-22 | Beiersdorf Ag, 2000 Hamburg | SUBSTITUTED 5-PHENYLTHIO-6-AMINO-PYRIMIDINONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE, AND PREPARATIONS CONTAINING THESE COMPOUNDS |
| JPH0655686B2 (en) * | 1988-08-30 | 1994-07-27 | 宇部興産株式会社 | Process for producing p-bromophenoxyacetaldehyde dialkyl acetals |
| KR101452518B1 (en) | 2005-08-22 | 2014-10-21 | 멜리어 파마슈티칼스 아이, 인코포레이티드 | Methods and formulations for modulating lyn kinase activity and treating related disorders |
| US8552184B2 (en) | 2008-07-03 | 2013-10-08 | Melior Pharmaceuticals I, Inc. | Compounds and methods for treating disorders related to glucose metabolism |
| WO2011150300A1 (en) | 2010-05-28 | 2011-12-01 | Melior Pharmaceuticals I, Inc. | Prevention of pancreatic beta cell degeneration |
| CN110785170B (en) | 2017-04-10 | 2023-03-28 | 梅里奥尔医药I公司 | Treatment of adipocytes |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2913462A (en) * | 1959-11-17 | Eahl h | ||
| GB951432A (en) * | 1959-03-17 | 1964-03-04 | Wellcome Found | Pyrimidine derivatives and the manufacture thereof |
-
0
- BE BE790125D patent/BE790125A/en not_active IP Right Cessation
-
1972
- 1972-02-18 GB GB774872A patent/GB1377308A/en not_active Expired
- 1972-02-18 GB GB5005373A patent/GB1377720A/en not_active Expired
- 1972-09-25 SE SE7212358A patent/SE393376B/en unknown
- 1972-09-28 IL IL40458A patent/IL40458A/en unknown
- 1972-09-28 AU AU47228/72A patent/AU467600B2/en not_active Expired
- 1972-10-02 PH PH13959A patent/PH10129A/en unknown
- 1972-10-05 DE DE2248741A patent/DE2248741C3/en not_active Expired
- 1972-10-05 DE DE2264657A patent/DE2264657C2/en not_active Expired
- 1972-10-05 DE DE2264374A patent/DE2264374C3/en not_active Expired
- 1972-10-06 AT AT858972A patent/AT321308B/en not_active IP Right Cessation
- 1972-10-06 AT AT00933/74A patent/AT320656B/en not_active IP Right Cessation
- 1972-10-12 YU YU2551/72A patent/YU35125B/en unknown
- 1972-10-12 FI FI2825/72A patent/FI55503C/en active
- 1972-10-13 SU SU1839308A patent/SU498908A3/en active
- 1972-10-13 NO NO3686/72A patent/NO136574C/en unknown
- 1972-10-16 CH CH1507872A patent/CH555832A/en not_active IP Right Cessation
- 1972-10-16 PL PL1972174103A patent/PL89852B1/pl unknown
- 1972-10-16 LU LU66304A patent/LU66304A1/xx unknown
- 1972-10-16 CA CA153,956A patent/CA980778A/en not_active Expired
- 1972-10-16 PL PL1972158297A patent/PL84634B1/pl unknown
- 1972-10-16 IE IE1398/72A patent/IE37043B1/en unknown
- 1972-10-16 NL NL7213959.A patent/NL166470C/en not_active IP Right Cessation
- 1972-10-16 FR FR7236560A patent/FR2157865B1/fr not_active Expired
- 1972-10-16 CH CH165674A patent/CH549579A/en not_active IP Right Cessation
- 1972-10-16 DK DK510072AA patent/DK131465B/en not_active IP Right Cessation
- 1972-10-16 JP JP10279972A patent/JPS5337870B2/ja not_active Expired
- 1972-10-16 ZA ZA727362A patent/ZA727362B/en unknown
- 1972-10-18 ES ES407730A patent/ES407730A1/en not_active Expired
- 1972-10-19 EG EG431/72A patent/EG11013A/en active
- 1972-10-23 AR AR244763A patent/AR198798A1/en active
-
1973
- 1973-07-12 AR AR249053A patent/AR196263A1/en active
-
1974
- 1974-03-26 SU SU2008490A patent/SU505362A3/en active
-
1975
- 1975-04-15 ES ES436624A patent/ES436624A1/en not_active Expired
- 1975-05-06 SE SE7505279A patent/SE397090B/en unknown
- 1975-11-21 PH PH17784A patent/PH11594A/en unknown
-
1976
- 1976-01-05 IL IL48790A patent/IL48790A/en unknown
-
1978
- 1978-02-08 JP JP1336078A patent/JPS53116386A/en active Granted
-
1979
- 1979-04-25 YU YU991/79A patent/YU36295B/en unknown
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