GB1168391A - Substituted Uracils - Google Patents

Substituted Uracils

Info

Publication number
GB1168391A
GB1168391A GB99168A GB99168A GB1168391A GB 1168391 A GB1168391 A GB 1168391A GB 99168 A GB99168 A GB 99168A GB 99168 A GB99168 A GB 99168A GB 1168391 A GB1168391 A GB 1168391A
Authority
GB
United Kingdom
Prior art keywords
alkali metal
alpha
group
aqueous solution
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB99168A
Inventor
Solomon Aronovich Giller
Regina Abramovna Zhuk
Marger Jurievich Lidak
Aina Avgustovna Zidermane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST ORGANOCHESKOGO SINTEZA AN
Original Assignee
INST ORGANOCHESKOGO SINTEZA AN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST ORGANOCHESKOGO SINTEZA AN filed Critical INST ORGANOCHESKOGO SINTEZA AN
Priority to GB99168A priority Critical patent/GB1168391A/en
Publication of GB1168391A publication Critical patent/GB1168391A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

1,168,391. Substituted levacils. INSTITUT ORGANNICHESKOGO SINTEZA AN LATVIISKOI SSR. 8 Jan., 1968, No. 991/68. Heading C2C. Novel compounds of the formula and alkali metal salts thereof, in which R 1 is an alpha-furanidyl or alpha-pyramidyl group and R is a trifluoromethyl group or a fluorine or chlorine atom or (when R 1 is an alpha-furamidyl group) a methyl group or a bromine, or iodine atom, are produced by reacting a mercury or bis-trimethylsilyl derivative of an appropriate 5-substituted uracil with 2-chlorofuranidine or 2-chloropyramidine at a temperature of from - 60‹ to + 40‹ C. The compound obtained can be converted into an alakli metal salt thereof by reaction with an aqueous solution of alkali, an aqueous solution of an alkali metal salt of a weak acid or an alcoholic solution of an alkali metal alcoholate. A pharmaceutical composition comprising the above compounds and their alkali metal salts with a pharmaceutical carrier or diluent has antimetabolite activity and can be effectively used as anti-tumour and anti-virus agents and is administered by injection.
GB99168A 1968-01-08 1968-01-08 Substituted Uracils Expired GB1168391A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB99168A GB1168391A (en) 1968-01-08 1968-01-08 Substituted Uracils

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB99168A GB1168391A (en) 1968-01-08 1968-01-08 Substituted Uracils

Publications (1)

Publication Number Publication Date
GB1168391A true GB1168391A (en) 1969-10-22

Family

ID=40679607

Family Applications (1)

Application Number Title Priority Date Filing Date
GB99168A Expired GB1168391A (en) 1968-01-08 1968-01-08 Substituted Uracils

Country Status (1)

Country Link
GB (1) GB1168391A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960864A (en) * 1974-05-06 1976-06-01 The University Of Utah Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil
DE2648239A1 (en) * 1975-10-24 1977-04-28 Rikagaku Kenkyusho PROCESS FOR THE PRODUCTION OF NUCLEOSIDE-LIKE PYRIMIDINE DERIVATIVES
DE2650918A1 (en) * 1975-11-10 1977-05-26 Asahi Chemical Ind Anticancer (N-2)-furanidyl-(5)-fluoro-uracil prepn. - by reacting bis-trialkylsilyl (5)-fluoro uracil with (2,3)-dihydro-furan
US4371535A (en) 1976-01-07 1983-02-01 Taiho Pharmaceutical Company Limited Method of and composition for delivering 5-fluorouracil to tumors
WO1984003510A1 (en) * 1983-03-11 1984-09-13 Inst Khim Fiz An Sssr Nitroxyl derivatives of 5-fluorineuracil having antitumoral activity
CN102285972A (en) * 2011-08-08 2011-12-21 江苏大学 Process for preparing tegafur
EP2422848A1 (en) 2010-08-18 2012-02-29 Grindeks, a joint stock company Composition of tegafur, Indole-3-carbinol and either catechin, kaempherol, myricetin or luteolin for potentiating antitumour effect and for treating tumours
EP2422815A1 (en) 2010-08-18 2012-02-29 Grindeks, a joint stock company Pharmaceutical composition of tegafur and natural flavonoid derivative catechin for potentiating antitumour effect and for treating tumours
EP2422784A1 (en) 2010-08-18 2012-02-29 Grindeks, a joint stock company Composition of TEGAFUR, caffeic acid phenethyl ester (CAPE) and either catechin, kaempherol, myricetin or luteolin for potentiating antitumour effect and for treating tumours

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960864A (en) * 1974-05-06 1976-06-01 The University Of Utah Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil
DE2648239A1 (en) * 1975-10-24 1977-04-28 Rikagaku Kenkyusho PROCESS FOR THE PRODUCTION OF NUCLEOSIDE-LIKE PYRIMIDINE DERIVATIVES
DE2650918A1 (en) * 1975-11-10 1977-05-26 Asahi Chemical Ind Anticancer (N-2)-furanidyl-(5)-fluoro-uracil prepn. - by reacting bis-trialkylsilyl (5)-fluoro uracil with (2,3)-dihydro-furan
DE2650918C2 (en) * 1975-11-10 1983-06-09 Asahi Kasei Kogyo K.K., Osaka Process for the preparation of N? 1? - (2-tetrahydrofuranyl) -5-fluoro-uracil
US4371535A (en) 1976-01-07 1983-02-01 Taiho Pharmaceutical Company Limited Method of and composition for delivering 5-fluorouracil to tumors
WO1984003510A1 (en) * 1983-03-11 1984-09-13 Inst Khim Fiz An Sssr Nitroxyl derivatives of 5-fluorineuracil having antitumoral activity
US4558127A (en) * 1983-03-11 1985-12-10 Emanuel Nikolai M 5-Fluorouracil nitroxyl derivatives possessing antitumor activity
EP2422848A1 (en) 2010-08-18 2012-02-29 Grindeks, a joint stock company Composition of tegafur, Indole-3-carbinol and either catechin, kaempherol, myricetin or luteolin for potentiating antitumour effect and for treating tumours
EP2422815A1 (en) 2010-08-18 2012-02-29 Grindeks, a joint stock company Pharmaceutical composition of tegafur and natural flavonoid derivative catechin for potentiating antitumour effect and for treating tumours
EP2422784A1 (en) 2010-08-18 2012-02-29 Grindeks, a joint stock company Composition of TEGAFUR, caffeic acid phenethyl ester (CAPE) and either catechin, kaempherol, myricetin or luteolin for potentiating antitumour effect and for treating tumours
CN102285972A (en) * 2011-08-08 2011-12-21 江苏大学 Process for preparing tegafur

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years