GB1284582A - Substituted piperazinopyrimidinones - Google Patents
Substituted piperazinopyrimidinonesInfo
- Publication number
- GB1284582A GB1284582A GB5496669A GB5496669A GB1284582A GB 1284582 A GB1284582 A GB 1284582A GB 5496669 A GB5496669 A GB 5496669A GB 5496669 A GB5496669 A GB 5496669A GB 1284582 A GB1284582 A GB 1284582A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- give
- reacted
- quaternary ammonium
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1284582 Pyrazinopyrimidine derivatives COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH 10 Nov 1969 54966/69 Heading C2C Novel compounds I and their acid addition and quaternary ammonium salts in which R 1 and R 2 are 1-6C alkyl, are prepared by reaction of compounds II: with compounds III: to form compounds IV: which are then reacted to cleave the benzyloxycarbonyl group and give compounds V: which compounds are then reacted with P 2 O 5 to give compounds VI: which compounds VI are reacted with R 1 NH 2 to give compounds VII which compounds VII are then reduced to compounds VIII: which compounds are then reacted with ClCOOC 2 H 5 to give the N-ethoxycarbonyl derivatives IX which compounds are cyclized by treatment with alkali metal alkoxide to give compounds I. Compounds II to IX are isolated as intermediates. Pharmaceutical compositions for oral, rectal or parenteral administration as antifilarial agents contain a compound I or an acid addition or quaternary ammonium pharmacentically acceptable salt thereof and a suitable excipient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5496669A GB1284582A (en) | 1969-11-10 | 1969-11-10 | Substituted piperazinopyrimidinones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5496669A GB1284582A (en) | 1969-11-10 | 1969-11-10 | Substituted piperazinopyrimidinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1284582A true GB1284582A (en) | 1972-08-09 |
Family
ID=10472586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5496669A Expired GB1284582A (en) | 1969-11-10 | 1969-11-10 | Substituted piperazinopyrimidinones |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1284582A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2401923A1 (en) * | 1977-09-05 | 1979-03-30 | Ferrosan Ab | NEW OCTAHYDROPYRAZINOPYRIMIDINONES 2,3,4,7,8,9-SUBSTITUTES, PROCESS FOR PREPARATION OF THESE DERIVATIVES AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
| JP2013500314A (en) * | 2009-07-30 | 2013-01-07 | ラボラトリオス・サルバト・ソシエダッド・アノニマ | APAF-1 inhibitor compounds |
-
1969
- 1969-11-10 GB GB5496669A patent/GB1284582A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2401923A1 (en) * | 1977-09-05 | 1979-03-30 | Ferrosan Ab | NEW OCTAHYDROPYRAZINOPYRIMIDINONES 2,3,4,7,8,9-SUBSTITUTES, PROCESS FOR PREPARATION OF THESE DERIVATIVES AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
| JP2013500314A (en) * | 2009-07-30 | 2013-01-07 | ラボラトリオス・サルバト・ソシエダッド・アノニマ | APAF-1 inhibitor compounds |
| US9040701B2 (en) | 2009-07-30 | 2015-05-26 | Laboratorios Salvat, S.A. | Apaf-1 inhibitor compounds |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 435 | Patent endorsed 'licences of right' on the date specified (sect. 35/1949) | ||
| PCNP | Patent ceased through non-payment of renewal fee |