ES418987A1 - Phenylamidinourea derivatives processes for their preparation and compositions incorporating them - Google Patents
Phenylamidinourea derivatives processes for their preparation and compositions incorporating themInfo
- Publication number
- ES418987A1 ES418987A1 ES418987A ES418987A ES418987A1 ES 418987 A1 ES418987 A1 ES 418987A1 ES 418987 A ES418987 A ES 418987A ES 418987 A ES418987 A ES 418987A ES 418987 A1 ES418987 A1 ES 418987A1
- Authority
- ES
- Spain
- Prior art keywords
- halogen
- lower alkyl
- preparation
- halogen atom
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel phenylguanidines of the formula < IMAGE > in which X is a hydrogen or halogen atom, Y is a hydrogen or halogen atom or a halogen-lower alkyl, nitro, lower alkyl or lower alkoxy group and Z is a halogen-lower alkyl, halogen-lower alkoxy or lower alkylsulphonyl group or, if X and Y are not both hydrogen atoms, Z is a halogen atom, or a lower alkoxy, lower alkyl, nitro or cyano group, and their non-toxic acid addition salts are obtained by reacting an acid addition salt of a corresponding aniline with cyanamide. The salts obtained can be converted to the free bases. Both are therapeutically useful as blood pressure-lowering (anti-hypertensive) and cardiovascular agents. They are also useful intermediates for the preparation of corresponding phenylamidine-urea compounds, possessing the same therapeutic properties.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29147472A | 1972-09-22 | 1972-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES418987A1 true ES418987A1 (en) | 1976-07-01 |
Family
ID=23120445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES418987A Expired ES418987A1 (en) | 1972-09-22 | 1973-09-21 | Phenylamidinourea derivatives processes for their preparation and compositions incorporating them |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS593471B2 (en) |
| AR (1) | AR200024A1 (en) |
| BE (1) | BE805138A (en) |
| CA (1) | CA1041908A (en) |
| CH (2) | CH605703A5 (en) |
| DE (1) | DE2345951C2 (en) |
| ES (1) | ES418987A1 (en) |
| FR (1) | FR2200002B1 (en) |
| GB (5) | GB1451477A (en) |
| IL (1) | IL43280A (en) |
| NL (1) | NL7313040A (en) |
| PH (1) | PH12016A (en) |
| SE (2) | SE416952B (en) |
| ZA (1) | ZA737475B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4220658A (en) * | 1972-09-22 | 1980-09-02 | William H. Rorer, Inc. | Treatment of hypertension with amidinoureas |
| US4025652A (en) * | 1975-03-31 | 1977-05-24 | William H. Rorer, Inc. | Amidinoureas |
| US4326074A (en) | 1972-09-22 | 1982-04-20 | William H. Rorer, Inc. | Amidinoureas |
| US4488993A (en) * | 1972-09-22 | 1984-12-18 | William H. Rorer, Inc. | Amidinoureas |
| US4713382A (en) * | 1985-05-30 | 1987-12-15 | Syntex (U.S.A.) Inc. | N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents |
| ATE157351T1 (en) * | 1993-02-20 | 1997-09-15 | Hoechst Ag | SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICATION, AS INHIBITORS OF CELLULAR NA+/H+ EXCHANGE OR AS A DIAGNOSTIC, AND MEDICINE CONTAINING THEM |
-
1973
- 1973-09-10 PH PH15001A patent/PH12016A/en unknown
- 1973-09-12 DE DE2345951A patent/DE2345951C2/en not_active Expired
- 1973-09-13 CA CA181,015A patent/CA1041908A/en not_active Expired
- 1973-09-17 CH CH1330773A patent/CH605703A5/xx not_active IP Right Cessation
- 1973-09-17 CH CH1605977A patent/CH614430A5/en not_active IP Right Cessation
- 1973-09-20 AR AR250179A patent/AR200024A1/en active
- 1973-09-21 JP JP48107418A patent/JPS593471B2/en not_active Expired
- 1973-09-21 BE BE135886A patent/BE805138A/en not_active IP Right Cessation
- 1973-09-21 ES ES418987A patent/ES418987A1/en not_active Expired
- 1973-09-21 FR FR7333963A patent/FR2200002B1/fr not_active Expired
- 1973-09-21 SE SE7312880A patent/SE416952B/en unknown
- 1973-09-21 ZA ZA737475A patent/ZA737475B/en unknown
- 1973-09-21 NL NL7313040A patent/NL7313040A/xx not_active Application Discontinuation
- 1973-09-21 IL IL43280A patent/IL43280A/en unknown
- 1973-09-24 GB GB4465473A patent/GB1451477A/en not_active Expired
- 1973-09-24 GB GB2499276A patent/GB1451480A/en not_active Expired
- 1973-09-24 GB GB2491476A patent/GB1451479A/en not_active Expired
- 1973-09-24 GB GB3221175A patent/GB1451478A/en not_active Expired
-
1975
- 1975-05-30 GB GB23574/75A patent/GB1514198A/en not_active Expired
-
1976
- 1976-11-02 SE SE7612176A patent/SE416953B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU6047973A (en) | 1975-03-20 |
| GB1451477A (en) | 1976-10-06 |
| FR2200002B1 (en) | 1977-07-15 |
| GB1451480A (en) | 1976-10-06 |
| DE2345951A1 (en) | 1974-04-04 |
| NL7313040A (en) | 1974-03-26 |
| SE7612176L (en) | 1976-11-02 |
| AR200024A1 (en) | 1974-10-15 |
| FR2200002A1 (en) | 1974-04-19 |
| JPS4985046A (en) | 1974-08-15 |
| IL43280A (en) | 1977-06-30 |
| CH614430A5 (en) | 1979-11-30 |
| JPS593471B2 (en) | 1984-01-24 |
| ZA737475B (en) | 1974-10-30 |
| SE416953B (en) | 1981-02-16 |
| SE416952B (en) | 1981-02-16 |
| PH12016A (en) | 1978-10-06 |
| BE805138A (en) | 1974-01-16 |
| GB1451479A (en) | 1976-10-06 |
| CA1041908A (en) | 1978-11-07 |
| GB1451478A (en) | 1976-10-06 |
| GB1514198A (en) | 1978-06-14 |
| DE2345951C2 (en) | 1986-10-23 |
| CH605703A5 (en) | 1978-10-13 |
| IL43280A0 (en) | 1973-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES431058A1 (en) | N-{8 (Methoxymethyl-furyl)-methyl{9 -morphinans or -6,7-benzomorphans and salts thereof | |
| ES391299A1 (en) | 2-(n-allyl-phenylamino)-imidazolines-(2)and salts thereof | |
| ES394370A1 (en) | Pharmacologically active 3-piperazinyl-carbonyloxy-2-pyridyl-isoindolin-1-ones | |
| GB1450010A (en) | Preparation of triamino pyrimidine n-oxides | |
| GB1369248A (en) | Amides the preparation thereof and their use in pharmacjeutical compositions | |
| GB1364403A (en) | 1 - aminosulphonyl - 2 - aminobenzimidazoles process for their preparation and their fungicidal use | |
| ES418987A1 (en) | Phenylamidinourea derivatives processes for their preparation and compositions incorporating them | |
| ES368497A1 (en) | Novel imidazoline derivatives, the preparation thereof and compositions containing the same | |
| GB1323119A (en) | Arylimino-oxazolidines and their use as acaricides | |
| GB1435476A (en) | Thiazole derivatives processes for their preparation and compositions incorporating them | |
| ES390163A1 (en) | Procedure for the preparation of amino-derivatives of pirazolo (3,4-b) pyridine-5-carboxylic acids. (Machine-translation by Google Translate, not legally binding) | |
| ES423233A1 (en) | 2-phenylamino-imidazolines-(2) | |
| GB1364294A (en) | 2-styrylquinazoline compounds | |
| ES437803A1 (en) | Novel thiophene derivatives and their preparation | |
| ES419739A1 (en) | 2-aryl-amino-imidazoline-2 compounds | |
| GB1505020A (en) | Substituted 2-phenylimino-thiazolines a process for their preparation and their use as ectoparasiticides | |
| ES419019A1 (en) | Indolo-2,3-c quinolinone derivatives | |
| GB1384843A (en) | Benzofuran derivatives their preparation and compositions containing them | |
| GB1458898A (en) | Ortho alkoxyanilides a process for their preparation and pharmaceutical compositions containing them | |
| GB1501795A (en) | Phenylsulphonyl formamidine derivatives and their preparation and use | |
| ES451375A1 (en) | 2,4-diamino-5-benzylpyrimidines | |
| GB1511475A (en) | Hydrazinopyridazine derivatives having antihypertensive activity | |
| GB1299053A (en) | Substituted 6-nitroaniline derivatives, processes for their preparation, and their use as herbicidal agents | |
| ES290193A1 (en) | Heparin derivatives and methods for preparing same | |
| GB1264944A (en) |