GB1451480A - Processes for the preparation os substituted phenylguanidines and the compounds thus prepared - Google Patents
Processes for the preparation os substituted phenylguanidines and the compounds thus preparedInfo
- Publication number
- GB1451480A GB1451480A GB2499276A GB2499276A GB1451480A GB 1451480 A GB1451480 A GB 1451480A GB 2499276 A GB2499276 A GB 2499276A GB 2499276 A GB2499276 A GB 2499276A GB 1451480 A GB1451480 A GB 1451480A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- processes
- prepared
- preparation
- phenylguanidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1451480 Process for phenylguanidines WILLIAM H RORER Inc 24 Sept 1973 [22 Sept 1972] 24992/76 Divided out of 1451477 Heading C2C The invention comprises a process for making compounds (IV<SP>1</SP>) (wherein R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP>, R<SP>6</SP> and R<SP>6</SP>, which may be the same or different, are each a hydrogen or halogen atom or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkylsulphonyl, nitro or cyano group-provided at least one of R<SP>2</SP>, R<SP>3</SP>, R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> is other than hydrogen) and acid addition salts thereof, by condensing corresponding substituted anilines or salts thereof with cyanamide in a phenol, cresol or xylenol solvent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29147472A | 1972-09-22 | 1972-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1451480A true GB1451480A (en) | 1976-10-06 |
Family
ID=23120445
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3221175A Expired GB1451478A (en) | 1972-09-22 | 1973-09-24 | Phenylguanidine derivatives and processes for their preparation |
| GB2491476A Expired GB1451479A (en) | 1972-09-22 | 1973-09-24 | Phenylamidourea derivatives and processes for their preparation |
| GB4465473A Expired GB1451477A (en) | 1972-09-22 | 1973-09-24 | Phenylamidinourea derivatives processes for their preparation and compositions incorporating them |
| GB2499276A Expired GB1451480A (en) | 1972-09-22 | 1973-09-24 | Processes for the preparation os substituted phenylguanidines and the compounds thus prepared |
| GB23574/75A Expired GB1514198A (en) | 1972-09-22 | 1975-05-30 | Substituted phenylguanidine compounds processes for their preparation and pharmaceutical compositions containing the same |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3221175A Expired GB1451478A (en) | 1972-09-22 | 1973-09-24 | Phenylguanidine derivatives and processes for their preparation |
| GB2491476A Expired GB1451479A (en) | 1972-09-22 | 1973-09-24 | Phenylamidourea derivatives and processes for their preparation |
| GB4465473A Expired GB1451477A (en) | 1972-09-22 | 1973-09-24 | Phenylamidinourea derivatives processes for their preparation and compositions incorporating them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23574/75A Expired GB1514198A (en) | 1972-09-22 | 1975-05-30 | Substituted phenylguanidine compounds processes for their preparation and pharmaceutical compositions containing the same |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS593471B2 (en) |
| AR (1) | AR200024A1 (en) |
| BE (1) | BE805138A (en) |
| CA (1) | CA1041908A (en) |
| CH (2) | CH614430A5 (en) |
| DE (1) | DE2345951C2 (en) |
| ES (1) | ES418987A1 (en) |
| FR (1) | FR2200002B1 (en) |
| GB (5) | GB1451478A (en) |
| IL (1) | IL43280A (en) |
| NL (1) | NL7313040A (en) |
| PH (1) | PH12016A (en) |
| SE (2) | SE416952B (en) |
| ZA (1) | ZA737475B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025652A (en) * | 1975-03-31 | 1977-05-24 | William H. Rorer, Inc. | Amidinoureas |
| US4326074A (en) | 1972-09-22 | 1982-04-20 | William H. Rorer, Inc. | Amidinoureas |
| US4488993A (en) * | 1972-09-22 | 1984-12-18 | William H. Rorer, Inc. | Amidinoureas |
| US4220658A (en) * | 1972-09-22 | 1980-09-02 | William H. Rorer, Inc. | Treatment of hypertension with amidinoureas |
| US4713382A (en) * | 1985-05-30 | 1987-12-15 | Syntex (U.S.A.) Inc. | N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents |
| DK0612723T3 (en) * | 1993-02-20 | 1998-03-30 | Hoechst Ag | Substituted benzoylguanidines, method of preparation, their use as a drug, as an inhibitor of cellular Na + / H + exchange or as a diagnostic, and as a drug containing it |
-
1973
- 1973-09-10 PH PH15001A patent/PH12016A/en unknown
- 1973-09-12 DE DE2345951A patent/DE2345951C2/en not_active Expired
- 1973-09-13 CA CA181,015A patent/CA1041908A/en not_active Expired
- 1973-09-17 CH CH1605977A patent/CH614430A5/en not_active IP Right Cessation
- 1973-09-17 CH CH1330773A patent/CH605703A5/xx not_active IP Right Cessation
- 1973-09-20 AR AR250179A patent/AR200024A1/en active
- 1973-09-21 ZA ZA737475A patent/ZA737475B/en unknown
- 1973-09-21 IL IL43280A patent/IL43280A/en unknown
- 1973-09-21 SE SE7312880A patent/SE416952B/en unknown
- 1973-09-21 JP JP48107418A patent/JPS593471B2/en not_active Expired
- 1973-09-21 BE BE135886A patent/BE805138A/en not_active IP Right Cessation
- 1973-09-21 FR FR7333963A patent/FR2200002B1/fr not_active Expired
- 1973-09-21 ES ES418987A patent/ES418987A1/en not_active Expired
- 1973-09-21 NL NL7313040A patent/NL7313040A/xx not_active Application Discontinuation
- 1973-09-24 GB GB3221175A patent/GB1451478A/en not_active Expired
- 1973-09-24 GB GB2491476A patent/GB1451479A/en not_active Expired
- 1973-09-24 GB GB4465473A patent/GB1451477A/en not_active Expired
- 1973-09-24 GB GB2499276A patent/GB1451480A/en not_active Expired
-
1975
- 1975-05-30 GB GB23574/75A patent/GB1514198A/en not_active Expired
-
1976
- 1976-11-02 SE SE7612176A patent/SE416953B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2200002A1 (en) | 1974-04-19 |
| GB1451477A (en) | 1976-10-06 |
| DE2345951C2 (en) | 1986-10-23 |
| AR200024A1 (en) | 1974-10-15 |
| IL43280A (en) | 1977-06-30 |
| AU6047973A (en) | 1975-03-20 |
| DE2345951A1 (en) | 1974-04-04 |
| PH12016A (en) | 1978-10-06 |
| ES418987A1 (en) | 1976-07-01 |
| SE7612176L (en) | 1976-11-02 |
| JPS4985046A (en) | 1974-08-15 |
| GB1451478A (en) | 1976-10-06 |
| FR2200002B1 (en) | 1977-07-15 |
| JPS593471B2 (en) | 1984-01-24 |
| SE416953B (en) | 1981-02-16 |
| GB1451479A (en) | 1976-10-06 |
| BE805138A (en) | 1974-01-16 |
| CA1041908A (en) | 1978-11-07 |
| IL43280A0 (en) | 1973-11-28 |
| NL7313040A (en) | 1974-03-26 |
| ZA737475B (en) | 1974-10-30 |
| SE416952B (en) | 1981-02-16 |
| CH605703A5 (en) | 1978-10-13 |
| GB1514198A (en) | 1978-06-14 |
| CH614430A5 (en) | 1979-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |