ES451375A1 - 2,4-diamino-5-benzylpyrimidines - Google Patents

2,4-diamino-5-benzylpyrimidines

Info

Publication number
ES451375A1
ES451375A1 ES451375A ES451375A ES451375A1 ES 451375 A1 ES451375 A1 ES 451375A1 ES 451375 A ES451375 A ES 451375A ES 451375 A ES451375 A ES 451375A ES 451375 A1 ES451375 A1 ES 451375A1
Authority
ES
Spain
Prior art keywords
formula
image
benzylpyrimidines
diamino
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES451375A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Ludwig and Co GmbH
Original Assignee
Heumann Ludwig and Co GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Ludwig and Co GmbH filed Critical Heumann Ludwig and Co GmbH
Publication of ES451375A1 publication Critical patent/ES451375A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2,4-Diamino-5-benzylpyrimidines of the formula (I) < IMAGE > in which R is an alkyl group with 1-4 carbon atoms or a halogen atom are prepared by reacting an appropriate beta -aminoacrylonitrile of the formula (V) < IMAGE > in which R' is an anilino group which is optionally substituted, or a morpholino group, with guanidine to give a compound of the formula (VI) < IMAGE > and converting the latter by elimination of the methoxymethyl radical into the compound of the formula (I). The compounds (I) can be obtained as acid addition salts and be used for chemotherapeutic purposes.
ES451375A 1975-10-17 1976-09-09 2,4-diamino-5-benzylpyrimidines Expired ES451375A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2546667A DE2546667C3 (en) 1975-10-17 1975-10-17 2,4-DiamuH »-5- (3-methoxy-4-hydroxy-5-halobenzyl) -pyrimidines, and medicinal products containing these compounds

Publications (1)

Publication Number Publication Date
ES451375A1 true ES451375A1 (en) 1981-10-16

Family

ID=5959437

Family Applications (1)

Application Number Title Priority Date Filing Date
ES451375A Expired ES451375A1 (en) 1975-10-17 1976-09-09 2,4-diamino-5-benzylpyrimidines

Country Status (17)

Country Link
JP (1) JPS5251376A (en)
AR (1) AR210905A1 (en)
AT (1) AT352735B (en)
AU (1) AU1724576A (en)
BE (1) BE846397A (en)
CA (1) CA1055498A (en)
CH (1) CH623313A5 (en)
DE (1) DE2546667C3 (en)
ES (1) ES451375A1 (en)
FR (1) FR2327786A1 (en)
GB (1) GB1522537A (en)
GR (1) GR60352B (en)
HU (1) HU174155B (en)
IL (1) IL50430A0 (en)
MX (1) MX4485E (en)
NL (1) NL7609652A (en)
PT (1) PT65482B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2720771C3 (en) 1977-05-09 1979-11-29 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-Diamino-5- (33-dimethoxy-4thioalkyl-benzyD-pyrimidines, process for their preparation and pharmaceuticals containing these compounds
PT69656A (en) * 1978-05-24 1979-06-01 Wellcome Found Benzylpyrimidine compositions
HU188588B (en) * 1982-08-13 1986-04-28 Egyt Gyogyszervegyeszeti Gyar Process for the production of 2,4-diamino-5-benzyl-pyrimidine-derivatives

Also Published As

Publication number Publication date
FR2327786A1 (en) 1977-05-13
CH623313A5 (en) 1981-05-29
DE2546667A1 (en) 1977-04-28
PT65482A (en) 1976-09-01
IL50430A0 (en) 1976-11-30
MX4485E (en) 1982-05-21
NL7609652A (en) 1977-04-19
DE2546667C3 (en) 1978-10-12
CA1055498A (en) 1979-05-29
DE2546667B2 (en) 1978-02-09
AT352735B (en) 1979-10-10
FR2327786B1 (en) 1980-04-18
GR60352B (en) 1978-05-18
PT65482B (en) 1978-02-13
BE846397A (en) 1977-01-17
AR210905A1 (en) 1977-09-30
JPS5251376A (en) 1977-04-25
HU174155B (en) 1979-11-28
GB1522537A (en) 1978-08-23
AU1724576A (en) 1978-03-02
ATA649276A (en) 1979-03-15

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