GB1264944A - - Google Patents
Info
- Publication number
- GB1264944A GB1264944A GB1264944DA GB1264944A GB 1264944 A GB1264944 A GB 1264944A GB 1264944D A GB1264944D A GB 1264944DA GB 1264944 A GB1264944 A GB 1264944A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reacting
- phenyl
- formula
- mandelamidine
- iminoesters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,264,944. Mandelamidine derivatives. ORSYMONDE. 24 April, 1970 [24 April, 1969], No. 19890/70. Heading C2C. Novel mandelamidine derivatives of the Formula I wherein one of R 1 and R 2 is NO 2 or CH 3 SO 2 NH- and the other is H, NO 2 or CH 3 SO 2 NH-, or R 1 and R 2 are both Cl in the 3 and 4 positions of the phenyl nucleus, and R 3 and R 4 each are H, C 1-4 alkyl or phenyl or R 3 is H and R 4 is OH, and non-toxic acid addition salts thereof are prepared by reacting the appropriate mandelonitriles with aliphatic alcohols containing 1 to 4 carbon atoms, to form the corresponding iminoesters and then reacting these iminoesters with amines of the formula HNR 3 R 4 in which R 3 and R 4 each are H, C 1-4 alkyl or phenyl, and when compounds of the above Formula I, in which R 3 is H and R 4 is OH, are required, reacting mandelamidines of the above Formula I in which R 3 and R 4 are H, with hydroxylamine. 3,4-Dichloromandelonitrile is obtained by reacting 3,4-dichlorobenzaldehyde with an aqueous solution of potassium cyanide in the presence of hydrochloric acid and sodium bisulphite. Pharmaceutical compositions, suitable for oral or parenteral administration, contain the above novel compounds or their non-toxic acid addition salts in admixture with pharmaceutically acceptable carriers. The compositions may be used for the treatment of arterial hypertension.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR6913032A FR2036973A1 (en) | 1969-04-24 | 1969-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1264944A true GB1264944A (en) | 1972-02-23 |
Family
ID=9033019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1264944D Expired GB1264944A (en) | 1969-04-24 | 1970-04-24 |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS4843343B1 (en) |
BE (1) | BE748425A (en) |
CH (1) | CH511812A (en) |
DE (1) | DE2019307C3 (en) |
FR (1) | FR2036973A1 (en) |
GB (1) | GB1264944A (en) |
NL (1) | NL168217C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5498792A (en) * | 1993-09-16 | 1996-03-12 | Shionogi & Co., Ltd. | Process of producing N-alkylacetamides |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1121792B (en) * | 1978-07-03 | 1986-04-23 | Dow Chemical Co | A PROCESS TO PREPARE 2-NAPHTHALENETHANIMIDAMIDS N, N'-OF-SUBSTITUTES AND INTERMEDIATES USED IN THIS PROCESS |
-
1969
- 1969-04-24 FR FR6913032A patent/FR2036973A1/fr active Pending
-
1970
- 1970-04-03 CH CH498770A patent/CH511812A/en not_active IP Right Cessation
- 1970-04-03 BE BE748425D patent/BE748425A/en not_active IP Right Cessation
- 1970-04-22 DE DE2019307A patent/DE2019307C3/en not_active Expired
- 1970-04-24 JP JP45035074A patent/JPS4843343B1/ja active Pending
- 1970-04-24 GB GB1264944D patent/GB1264944A/en not_active Expired
- 1970-04-24 NL NLAANVRAGE7005978,A patent/NL168217C/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5498792A (en) * | 1993-09-16 | 1996-03-12 | Shionogi & Co., Ltd. | Process of producing N-alkylacetamides |
Also Published As
Publication number | Publication date |
---|---|
FR2036973A1 (en) | 1970-12-31 |
DE2019307C3 (en) | 1980-06-26 |
JPS4843343B1 (en) | 1973-12-18 |
CH511812A (en) | 1971-08-31 |
NL7005978A (en) | 1970-10-27 |
BE748425A (en) | 1970-09-16 |
DE2019307A1 (en) | 1970-11-12 |
NL168217C (en) | 1982-03-16 |
DE2019307B2 (en) | 1979-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PE20 | Patent expired after termination of 20 years |