KR950003267A - 아미노-치환된 티오에테르의 제조방법 - Google Patents

아미노-치환된 티오에테르의 제조방법 Download PDF

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Publication number
KR950003267A
KR950003267A KR1019940015725A KR19940015725A KR950003267A KR 950003267 A KR950003267 A KR 950003267A KR 1019940015725 A KR1019940015725 A KR 1019940015725A KR 19940015725 A KR19940015725 A KR 19940015725A KR 950003267 A KR950003267 A KR 950003267A
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South Korea
Prior art keywords
phenyl
compound
formula
process according
benzyl
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KR1019940015725A
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English (en)
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KR100286845B1 (ko
Inventor
쿤데 클라우스
헤르트 칼-요제프
Original Assignee
귄터 슈마허, 에른스트 로이터
바이엘 아크티엔게젤샤프트
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Priority claimed from DE19934322053 external-priority patent/DE4322053A1/de
Priority claimed from DE19934332978 external-priority patent/DE4332978A1/de
Application filed by 귄터 슈마허, 에른스트 로이터, 바이엘 아크티엔게젤샤프트 filed Critical 귄터 슈마허, 에른스트 로이터
Publication of KR950003267A publication Critical patent/KR950003267A/ko
Application granted granted Critical
Publication of KR100286845B1 publication Critical patent/KR100286845B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/29—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 2-머캅토에탄올과 하기 일반식(Ⅱ)의 화합물을 반응시켜 하기 일반식(Ⅰ)의 화합물을 제조하는 방법에 관한 것이다.
상기식에서, R, R1내지 R6은 서로 독립적으로 수소, C1-C4-알킬, OH-, C1-C4-알콕시- 또는 SO3H-치환된 C1-C4-알킬, 페닐, 벤질, 또는 할로겐-, C1-C4-알콕시- 또는 SO3H-치환된 페닐 또는 벤질을 나타내고, n은 0 또는 1을 나타낸다.

Description

아미노-치환된 티오에테르의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 2-머캅토에탄올을 하기 일반식(Ⅱ)의 화합물과 반응시킴을 특징으로 하여 하기 일반식(Ⅰ)의 화합물을 제조하는 방법.
    상기식에서, R, R1내지 R6은 서로 독립적으로 수소, C1-C4-알킬, OH-, C1-C4-알콕시- 또는 SO3H-치환된 C1-C4-알킬, 페닐, 벤질, 또는 할로겐-, C1-C4-알콕시- 또는 SO3H-치환된 페닐 또는 벤질을 나타내고, n은 0 또는 1을 나타낸다
  2. 제1항에 있어서, R이 수소, 메틸, 에틸, 페닐 또는 벤질을 나타내고, R1내지 R6이 서로 독립적으로 수소, 메틸 및 페닐을 나타냄을 특징으로 하는 방법.
  3. 제1항에 있어서, 치환체 R1내지 R6이 수소를 나타냄을 특징으로 하는 방법.
  4. 제1항에 있어서, 반응을 염기, 바람직하게는 일반식(Ⅱ)의 화합물에 대해 등몰량인 염기로 수행함을 특징으로 하는 방법.
  5. 제4항에 있어서, 반응을 50 내지 150℃, 바람직하게는 60 내지 100℃의 온도에서 수행함을 특징으로 하는 방법.
  6. 제1항에 있어서, 반응을 n이 0인 일반식(Ⅱ)의 화합물로 수행함을 특징으로 하는 방법.
  7. 제6항에 있어서, 반응을 100 내지 250℃, 바람직하게는 150 내지 200℃의 온도에서 수행함을 특징으로 하는 방법.
  8. 제1항 내지 제7항중의 어느 한 항에 있어서, 사용되는 일반식(Ⅱ)의 화합물이 3-페닐-2-옥사졸리디논, 3-메틸-옥사졸리디논, 2-옥사졸리디논, 3-메틸-테트라하이드로[1,3]옥사진-2-온 또는 3-페닐-테트라하이드로[1,3]옥사진-2-온임을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940015725A 1993-07-02 1994-07-01 아미노-치환된 티오에테르의 제조방법 KR100286845B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP4322053.3 1993-07-02
DE19934322053 DE4322053A1 (de) 1993-07-02 1993-07-02 Verfahren zur Herstellung von aminosubstituierten Thioethern
DE19934332978 DE4332978A1 (de) 1993-09-28 1993-09-28 Verfahren zur Herstellung von aminosubstituierten Thioethern
DEP4332978.0 1993-09-28

Publications (2)

Publication Number Publication Date
KR950003267A true KR950003267A (ko) 1995-02-16
KR100286845B1 KR100286845B1 (ko) 2001-04-16

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Country Link
US (1) US5410081A (ko)
EP (1) EP0632022B1 (ko)
JP (1) JPH0717946A (ko)
KR (1) KR100286845B1 (ko)
CN (1) CN1038127C (ko)
DE (1) DE59401383D1 (ko)
TW (1) TW280812B (ko)

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DE4441147A1 (de) * 1994-11-18 1996-05-23 Hoechst Ag Verfahren zur Herstellung von 3-(N-Aryl-amino)-propyl-2'-sulfatoethyl-sulfonyl-Verbindungen
CN1049623C (zh) * 1994-12-06 2000-02-23 叶元龙 聚乙烯类板材的熔接方法及其装置
WO1998004534A1 (fr) 1996-07-31 1998-02-05 Nikken Chemicals Co., Ltd. Derives de 6-phenyltetrahydro-1,3-oxazine-2-one et compositions medicinales a base de ces composes
TW200732313A (en) * 2005-12-15 2007-09-01 Astrazeneca Ab Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators
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AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
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JP5730021B2 (ja) * 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
CA2723032A1 (en) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR071609A1 (es) * 2008-05-01 2010-06-30 Vitae Pharmaceuticals Inc Inhibidores ciclicos de 11(beta) -hidroxiesteroide deshidrogenasa 1
EP2291370B1 (en) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR071236A1 (es) 2008-05-01 2010-06-02 Vitae Pharmaceuticals Inc Inhibidores ciclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
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EP2393807B1 (en) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
US20100331320A1 (en) * 2009-04-30 2010-12-30 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
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Also Published As

Publication number Publication date
CN1097739A (zh) 1995-01-25
EP0632022B1 (de) 1996-12-27
JPH0717946A (ja) 1995-01-20
EP0632022A3 (en) 1995-02-01
DE59401383D1 (de) 1997-02-06
KR100286845B1 (ko) 2001-04-16
US5410081A (en) 1995-04-25
EP0632022A2 (de) 1995-01-04
TW280812B (ko) 1996-07-11
CN1038127C (zh) 1998-04-22

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