DE68929330D1 - Zwischenprodukte für die Herstellung von Derivaten der 4-Oxochinolin-3-carbonsäure - Google Patents

Zwischenprodukte für die Herstellung von Derivaten der 4-Oxochinolin-3-carbonsäure

Info

Publication number
DE68929330D1
DE68929330D1 DE68929330T DE68929330T DE68929330D1 DE 68929330 D1 DE68929330 D1 DE 68929330D1 DE 68929330 T DE68929330 T DE 68929330T DE 68929330 T DE68929330 T DE 68929330T DE 68929330 D1 DE68929330 D1 DE 68929330D1
Authority
DE
Germany
Prior art keywords
oxoquinoline
intermediates
derivatives
preparation
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68929330T
Other languages
English (en)
Other versions
DE68929330T2 (de
Inventor
Masayuki Iwata
Tomio Kimura
Teruhiko Inoue
Yoshimi Fujihara
Tetsushi Katsube
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Publication of DE68929330D1 publication Critical patent/DE68929330D1/de
Application granted granted Critical
Publication of DE68929330T2 publication Critical patent/DE68929330T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DE68929330T 1988-07-20 1989-07-20 Zwischenprodukte für die Herstellung von Derivaten der 4-Oxochinolin-3-carbonsäure Expired - Fee Related DE68929330T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18055788 1988-07-20
JP22422088 1988-09-07

Publications (2)

Publication Number Publication Date
DE68929330D1 true DE68929330D1 (de) 2001-11-08
DE68929330T2 DE68929330T2 (de) 2002-07-04

Family

ID=26500036

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68929330T Expired - Fee Related DE68929330T2 (de) 1988-07-20 1989-07-20 Zwischenprodukte für die Herstellung von Derivaten der 4-Oxochinolin-3-carbonsäure
DE68920654T Expired - Fee Related DE68920654T2 (de) 1988-07-20 1989-07-20 4-Oxochinolin-3-carbonsäure-Derivate, ihre Herstellung und ihre Verwendung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE68920654T Expired - Fee Related DE68920654T2 (de) 1988-07-20 1989-07-20 4-Oxochinolin-3-carbonsäure-Derivate, ihre Herstellung und ihre Verwendung.

Country Status (14)

Country Link
US (4) US5348961A (de)
EP (2) EP0352123B1 (de)
KR (2) KR950010325B1 (de)
CN (1) CN1028226C (de)
AT (2) ATE117295T1 (de)
AU (1) AU618823B2 (de)
CA (1) CA1335670C (de)
DE (2) DE68929330T2 (de)
DK (1) DK175617B1 (de)
ES (1) ES2070175T3 (de)
FI (1) FI95130C (de)
GR (1) GR3015818T3 (de)
IE (1) IE68941B1 (de)
NO (1) NO175256C (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
DE4015299A1 (de) * 1990-05-12 1991-11-14 Bayer Ag Verfahren zur herstellung von 3-amino-2-(het)-aroyl-acrylsaeurederivaten
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
JP3165742B2 (ja) * 1991-07-16 2001-05-14 中外製薬株式会社 キノロンカルボン酸誘導体の製造方法
EP0545866A1 (de) * 1991-12-06 1993-06-09 Ciba-Geigy Ag Verfahren zur Herstellung von Trifluorbenzolderivaten
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
TW222272B (de) * 1992-05-26 1994-04-11 Ss Seiyaku Kk
DE4232505A1 (de) * 1992-09-29 1994-03-31 Degussa Verfahren zur Reduktion von Carbonsäuren oder Carbonsäurederivaten sowie neue Verbindungen
CA2152828A1 (en) * 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
FR2706459B1 (fr) * 1993-06-17 1995-08-04 Bouchara Sa Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent.
US6964611B2 (en) * 1996-12-30 2005-11-15 Walker Digital, Llc System and method for automated play of lottery games
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
WO1999014214A1 (en) 1997-09-15 1999-03-25 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
WO2000029369A1 (fr) 1998-11-18 2000-05-25 Asahi Glass Company Ltd. Derives d'acide aminoacrylique et procede de production correspondant
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
CN1312131C (zh) * 2000-02-09 2007-04-25 第一制药株式会社 包含作为活性成分的吡啶酮羧酸的抗耐酸细菌药
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) * 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
CA2537066C (en) * 2003-09-04 2011-05-24 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
ES2232309B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Procedimiento simplificado para la obtencion de gatifloxacino.
DE102004035203A1 (de) 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
ES2284380B1 (es) * 2006-03-10 2008-11-01 Quimica Sintetica S.A. Procedimiento para la preparacion de moxifloxacino y moxifloxacino clorhidrato.
CA2647457C (en) * 2006-03-28 2011-05-24 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
SMP200800058B (it) * 2006-03-28 2009-09-07 Procter & Gamble Sali e polimorfi malati di un acido (3s, 5s) -7- [3-ammino-5-metilpiperidinil]-1-ciclopropil-1,4-diidro-8-metossi-4-osso-3-chinolincarbossilico
MX2008012488A (es) * 2006-03-28 2008-10-10 Procter & Gamble Un proceso de acoplamiento para preparar intermedios de quinolona.
CN100415212C (zh) * 2006-07-21 2008-09-03 哈药集团制药总厂 一种含乳酸卡德沙星的口服制剂
WO2008144536A1 (en) 2007-05-17 2008-11-27 Walker Digital, Llc Group play of lottery game
CN101775005B (zh) * 2009-01-13 2013-12-04 江苏恒瑞医药股份有限公司 盐酸卡屈沙星i型结晶及其制备方法
CN108129404B (zh) * 2018-01-30 2020-05-01 凯瑞斯德生化(苏州)有限公司 手性哌嗪酮衍生物的合成方法
CN108299317A (zh) * 2018-03-20 2018-07-20 爱斯特(成都)生物制药股份有限公司 1,4-二氮杂螺[5,5]十一烷盐酸盐的合成方法
CN108840814B (zh) * 2018-07-24 2021-09-24 南京药石科技股份有限公司 一种8-氧代-2,6,9-三氮杂螺[4.5]癸烷-2-羧酸叔丁酯制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた8‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd 8位置換キノロンカルボン酸誘導体
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
NO871333L (no) * 1986-03-31 1987-10-01 Sankyo Co Kinolin-3-karboksylsyrederivater, fremgangsmaate til fremstilling og anvendelse derav.
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4803205A (en) * 1987-08-07 1989-02-07 Warner-Lambert Company Quinolones as antibacterial agents
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent

Also Published As

Publication number Publication date
CN1040977A (zh) 1990-04-04
EP0610958A2 (de) 1994-08-17
DK175617B1 (da) 2004-12-27
EP0610958B1 (de) 2001-10-04
EP0610958A3 (de) 1995-03-22
US5436367A (en) 1995-07-25
NO175256B (no) 1994-06-13
ES2070175T3 (es) 1995-06-01
FI893467A (fi) 1990-01-21
AU618823B2 (en) 1992-01-09
IE892340L (en) 1990-01-20
FI95130C (fi) 1995-12-27
US5348961A (en) 1994-09-20
DE68920654T2 (de) 1995-08-31
AU3821889A (en) 1990-01-25
DE68929330T2 (de) 2002-07-04
GR3015818T3 (en) 1995-07-31
EP0352123B1 (de) 1995-01-18
CA1335670C (en) 1995-05-23
EP0352123A2 (de) 1990-01-24
ATE206401T1 (de) 2001-10-15
DK359289D0 (da) 1989-07-19
NO892952L (no) 1990-01-22
DK359289A (da) 1990-01-21
EP0352123A3 (en) 1990-09-05
US5073556A (en) 1991-12-17
NO175256C (no) 1994-09-21
KR950010325B1 (ko) 1995-09-14
CN1028226C (zh) 1995-04-19
ATE117295T1 (de) 1995-02-15
FI95130B (fi) 1995-09-15
US5496951A (en) 1996-03-05
KR900001686A (ko) 1990-02-27
FI893467A0 (fi) 1989-07-18
NO892952D0 (no) 1989-07-19
DE68920654D1 (de) 1995-03-02
IE68941B1 (en) 1996-07-24
KR950011396B1 (ko) 1995-10-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee