BR0306811A - Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero - Google Patents

Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero

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Publication number
BR0306811A
BR0306811A BR0306811-0A BR0306811A BR0306811A BR 0306811 A BR0306811 A BR 0306811A BR 0306811 A BR0306811 A BR 0306811A BR 0306811 A BR0306811 A BR 0306811A
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Brazil
Prior art keywords
group
pharmacologically acceptable
hydrogen atom
transplantation
prevention
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Pending
Application number
BR0306811-0A
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English (en)
Inventor
Takahide Nishi
Takaichi Shimozato
Futoshi Nara
Shojiro Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
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Sankyo Co Ltd
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Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of BR0306811A publication Critical patent/BR0306811A/pt
Pending legal-status Critical Current

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Abstract

"COMPOSTO, éSTER FARMACOLOGICAMENTE ACEITáVEL DO MESMO, COMPOSIçãO FARMACêUTICA E MéTODOS PARA PREVENçãO OU TRATAMENTO DE DOENçAS AUTOIMUNES, DA ARTRITE REUMATóIDE E DA REJEIçãO CAUSADA PELO TRANSPLANTE DE VáRIOS óRGãOS EM UM MAMìFERO". A presente invenção diz respeito aos derivados de amina álcool ou derivados de ácido fosfónico tendo excelente atividade imunossupressiva, sais destes farmacologicamente aceitáveis ou ésteres destes farmacologicamente aceitáveis e as composições farmacêuticas que compreendam os ditos compostos como um ingrediente ativo: [em que, R^ 1^ e R^ 2^ cada um representa um átomo de hidrogênio ou um grupo de proteção do grupo amino; ^ 3^ representa um átomo de hidrogênio ou um grupo de proteção do grupo hidroxila; R^ 4^ representa um grupo alquila inferior; n representa um número inteiro de 1 a 6; X representa um átomo de oxigênio ou um átomo de nitrogênio não substituído ou substituido com um grupo alquila inferior ou similar; Y representa um grupo etileno; Z representa um grupo alquileno C~ 1~-C~ 10~; R^ 5^ representa um grupo arila ou um grupo arila substituído com substituintes; R^ 6^ e R^ 7^ cada um representa um átomo de hidrogênio; contanto que quando R^ 5^ representa um átomo de hidrogênio, então Z representa um grupo outro que não uma ligação única ou um grupo alquileno C~ 1~-C~ 10~ de cadeia reta].
BR0306811-0A 2002-01-11 2003-01-09 Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero Pending BR0306811A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002004484 2002-01-11
JP2002004456 2002-01-11
PCT/JP2003/000136 WO2003059880A1 (fr) 2002-01-11 2003-01-09 Derive d'amino-alcool ou derive d'acide phosphonique et composition medicamenteuse les contenant

Publications (1)

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BR0306811A true BR0306811A (pt) 2004-10-26

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BR0306811-0A Pending BR0306811A (pt) 2002-01-11 2003-01-09 Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero

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US (5) US7199150B2 (pt)
EP (1) EP1471054B1 (pt)
JP (1) JP4270541B2 (pt)
KR (2) KR20080035702A (pt)
CN (1) CN100406437C (pt)
AT (1) ATE435202T1 (pt)
AU (1) AU2003202495B2 (pt)
BR (1) BR0306811A (pt)
CA (1) CA2473461C (pt)
CO (1) CO5640126A2 (pt)
CY (1) CY1109457T1 (pt)
DE (1) DE60328161D1 (pt)
DK (1) DK1471054T3 (pt)
ES (1) ES2327825T3 (pt)
HK (1) HK1066532A1 (pt)
IL (1) IL162874A0 (pt)
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