WO2003059880A1 - Derive d'amino-alcool ou derive d'acide phosphonique et composition medicamenteuse les contenant - Google Patents
Derive d'amino-alcool ou derive d'acide phosphonique et composition medicamenteuse les contenant Download PDFInfo
- Publication number
- WO2003059880A1 WO2003059880A1 PCT/JP2003/000136 JP0300136W WO03059880A1 WO 2003059880 A1 WO2003059880 A1 WO 2003059880A1 JP 0300136 W JP0300136 W JP 0300136W WO 03059880 A1 WO03059880 A1 WO 03059880A1
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- WIPO (PCT)
- Prior art keywords
- derivative
- composition containing
- phosphonic acid
- medicinal composition
- amino alcohol
- Prior art date
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- 150000001414 amino alcohols Chemical class 0.000 title abstract 2
- 150000003007 phosphonic acid derivatives Chemical class 0.000 title abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 229910052757 nitrogen Chemical group 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
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- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
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Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03701048A EP1471054B1 (en) | 2002-01-11 | 2003-01-09 | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
DE60328161T DE60328161D1 (de) | 2002-01-11 | 2003-01-09 | Aminoalkoholderivat oder phosphonsäurederivat und diese enthaltende medizinische zusammensetzung |
AT03701048T ATE435202T1 (de) | 2002-01-11 | 2003-01-09 | Aminoalkoholderivat oder phosphonsäurederivat und diese enthaltende medizinische zusammensetzung |
BR0306811-0A BR0306811A (pt) | 2002-01-11 | 2003-01-09 | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
KR1020047010719A KR100836547B1 (ko) | 2002-01-11 | 2003-01-09 | 아미노 알코올 유도체 또는 포스폰산 유도체 및 이들을함유하는 의약 조성물 |
CA2473461A CA2473461C (en) | 2002-01-11 | 2003-01-09 | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
DK03701048T DK1471054T3 (da) | 2002-01-11 | 2003-01-09 | Aminoalkohol-derivat eller phosphonsyre-derivat og medicinsk sammensætning, der indeholder disse |
NZ533994A NZ533994A (en) | 2002-01-11 | 2003-01-09 | Amino alcohol derivative or phosphonic acid derivative and medicinal compostion containing these |
AU2003202495A AU2003202495B2 (en) | 2002-01-11 | 2003-01-09 | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
SI200331668T SI1471054T1 (sl) | 2002-01-11 | 2003-01-09 | Amino alkoholni derivati ali derivati fosfoniäśne kisline in medicinski sestavki, ki vsebujejo le-te |
MXPA04006709A MXPA04006709A (es) | 2002-01-11 | 2003-01-09 | Derivados de aminoalcohol o derivados de acido fosfonico y composiciones farmaceuticas que los contienen. |
IL16287403A IL162874A0 (en) | 2002-01-11 | 2003-01-09 | Amino alcohol and phosphonic acid derivatives and pharmaceutical compositions containing the same |
US10/889,657 US7199150B2 (en) | 2002-01-11 | 2004-07-12 | Amino alcohol compounds |
ZA2004/06333A ZA200406333B (en) | 2002-01-11 | 2004-08-10 | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
NO20043319A NO329134B1 (no) | 2002-01-11 | 2004-08-10 | Aminoalkoholderivater eller fosfonsyrederivater og farmasoytiske preparater som inneholder disse og som kan anvendes ved profylakse eller behandling av autoimmunsykdommer |
HK04109418.1A HK1066532A1 (en) | 2002-01-11 | 2004-11-30 | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
US11/636,776 US20070105933A1 (en) | 2002-01-11 | 2006-12-11 | Amino alcohol compounds |
US11/651,205 US7638551B2 (en) | 2002-01-11 | 2007-01-09 | Amino alcohol compounds or phosphonic acid derivatives thereof |
US12/460,884 US8067396B2 (en) | 2002-01-11 | 2009-07-24 | Amino alcohol compounds or phosphonic acid derivatives thereof |
US12/583,001 US8101650B2 (en) | 2002-01-11 | 2009-08-12 | Method for treating a immunology-related disease |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002004456 | 2002-01-11 | ||
JP2002-004456 | 2002-01-11 | ||
JP2002-004484 | 2002-01-11 | ||
JP2002004484 | 2002-01-11 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/889,657 Continuation-In-Part US7199150B2 (en) | 2002-01-11 | 2004-07-12 | Amino alcohol compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003059880A1 true WO2003059880A1 (fr) | 2003-07-24 |
Family
ID=26625490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/000136 WO2003059880A1 (fr) | 2002-01-11 | 2003-01-09 | Derive d'amino-alcool ou derive d'acide phosphonique et composition medicamenteuse les contenant |
Country Status (26)
Country | Link |
---|---|
US (5) | US7199150B2 (ja) |
EP (1) | EP1471054B1 (ja) |
JP (1) | JP4270541B2 (ja) |
KR (2) | KR100836547B1 (ja) |
CN (1) | CN100406437C (ja) |
AT (1) | ATE435202T1 (ja) |
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Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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WO2005030848A1 (en) * | 2003-09-19 | 2005-04-07 | Dow Global Technologies Inc. | Multifunctional monomers and polyarylene compositions therefrom |
WO2006137509A1 (ja) * | 2005-06-24 | 2006-12-28 | Daiichi Sankyo Company, Limited | Ppar調節剤を含有する医薬組成物 |
WO2008016133A1 (fr) | 2006-08-04 | 2008-02-07 | Daiichi Sankyo Company, Limited | Enzyme de phosphorylation d'un médicament |
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TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
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WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006068A1 (fr) * | 1994-08-22 | 1996-02-29 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose benzenique et son utilisation medicale |
WO2002006268A1 (fr) * | 2000-07-13 | 2002-01-24 | Sankyo Company, Limited | Derives d'alcool amino |
WO2002018395A1 (en) * | 2000-08-31 | 2002-03-07 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
WO2002076995A2 (en) * | 2001-03-26 | 2002-10-03 | Novartis Ag | 2-amino-propanol derivatives |
Family Cites Families (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1134687A (en) | 1966-04-28 | 1968-11-27 | Beecham Group Ltd | Acetylenic compounds |
IL36730A0 (en) * | 1970-05-28 | 1971-06-23 | Chemagro Corp | Phosphonamidothioates,their preparation and their use as herbicides and/or plant growth regulators |
DK150068C (da) | 1978-06-02 | 1987-06-29 | Pfizer | Analogifremgangsmaade til fremstilling af aminothiazoler |
FR2460919A1 (fr) | 1979-07-11 | 1981-01-30 | Prod Synthese Ste Indle | Amino-ethers oxydes, leur procede de preparation et leur application en therapeutique |
US4363918A (en) * | 1979-09-11 | 1982-12-14 | Janssen Pharmaceutica N.V. | Method of preparing 1-alkyl-3-carboxy-1H pyrrole-2-acetic acids |
US4386090A (en) * | 1980-12-22 | 1983-05-31 | Delalande S.A. | Nitrogen containing 2,3-dihydro naphthalenes, compositions and use |
US4716155A (en) * | 1981-12-24 | 1987-12-29 | E. R. Squibb & Sons, Inc. | Phosphorus containing compounds and hypotensive use thereof |
IT1190793B (it) * | 1982-04-27 | 1988-02-24 | Magis Farmaceutici | Composti attivi nel trattamento dell'ulcera e sintomi allergici della pelle |
US4536601A (en) * | 1982-09-28 | 1985-08-20 | Dainippon Pharmaceutical Co., Ltd. | Optically active N-substituted phenylalaninols and use thereof |
JPS5988467A (ja) | 1982-11-09 | 1984-05-22 | Yoshitomi Pharmaceut Ind Ltd | フエノキシアミノプロパノ−ル誘導体 |
DK302185A (da) | 1984-07-05 | 1986-01-06 | Rolland Sa A | 2-amino-oxazoliner samt fremgangsmaade til deres fremstilling |
US4634689A (en) * | 1985-10-31 | 1987-01-06 | Schering Corporation | Phosphinylalkanoyl imino acids |
US4667038A (en) * | 1985-12-02 | 1987-05-19 | Syntex (U.S.A.) Inc. | Tetrahydroisoquinoline derivatives |
US4792568A (en) * | 1986-04-14 | 1988-12-20 | Rorer Pharmaceutical Corporation | Aryl pyrroles as useful antiallergy compounds |
JPS63126897A (ja) * | 1986-05-02 | 1988-05-30 | Yoshitomi Pharmaceut Ind Ltd | 免疫抑制因子 |
US5135947A (en) * | 1987-04-09 | 1992-08-04 | Eli Lilly And Company | 1-phenyl-3-naphthalenyloxypropanamines and their use as selective serotonin reuptake inhibitors |
GB8712694D0 (en) * | 1987-05-29 | 1987-07-01 | Scras | Tetrahydrofurans etc |
IL86740A (en) | 1987-06-30 | 1992-11-15 | Tanabe Seiyaku Co | Thiphene derivatives,their preparation and pharmaceutical compositions containing them |
EP0300688A1 (en) | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
CA1334975C (en) * | 1987-11-13 | 1995-03-28 | James H. Holms | Furan and pyrrole containing lipoxygenase inhibiting compounds |
US5039706A (en) * | 1987-11-30 | 1991-08-13 | Du Pont Merck Pharmaceutical Company | Antiinflammatory PLA2 inhibitors |
DK702188A (da) * | 1987-12-18 | 1989-06-19 | Glaxo Group Ltd | Ethanolaminderivater |
US4977171A (en) * | 1988-06-09 | 1990-12-11 | Yashima Chemical Industrial Co., Ltd. | Oxa- or thia-zoline derivative |
WO1990002727A1 (en) * | 1988-09-14 | 1990-03-22 | Yoshitomi Pharmaceutical Industries, Ltd. | Immunosuppressant |
US5266599A (en) * | 1989-02-20 | 1993-11-30 | Jouveinal S.A. | Use of (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine to increase gastric discharge in a subject |
EP0410176A1 (en) * | 1989-07-07 | 1991-01-30 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-Aminopentanoic acid compounds and their use as immunosuppressants |
HU212415B (en) * | 1989-08-25 | 1996-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing new cyclic oxym derivatives and pharmaceutical compositions containing them as active components |
US5234934A (en) * | 1989-08-25 | 1993-08-10 | Egis Gyogyszergyar | Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same |
FR2655043B1 (fr) * | 1989-11-24 | 1992-02-07 | Adir | Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
US5037853A (en) * | 1989-12-28 | 1991-08-06 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
GB9000644D0 (en) * | 1990-01-11 | 1990-03-14 | Erba Carlo Spa | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
US5723218A (en) | 1990-04-16 | 1998-03-03 | Molecular Probes, Inc. | Dipyrrometheneboron difluoride labeled flourescent microparticles |
US5433896A (en) * | 1994-05-20 | 1995-07-18 | Molecular Probes, Inc. | Dibenzopyrrometheneboron difluoride dyes |
US5648270A (en) * | 1995-02-06 | 1997-07-15 | Molecular Probes, Inc. | Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles |
US5501980A (en) * | 1994-05-20 | 1996-03-26 | Molecular Probes, Inc. | Benzazolylcoumarin-based ion indicators |
US5326692B1 (en) * | 1992-05-13 | 1996-04-30 | Molecular Probes Inc | Fluorescent microparticles with controllable enhanced stokes shift |
US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
DK0492497T3 (da) | 1990-12-24 | 1997-01-06 | Hoechst Ag | Fremgangsmåde til acylering af alkoholer med en immobiliseret pseudomonas-lipase |
CA2071621C (en) | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Aldehyde derivatives |
NL9101623A (nl) * | 1991-09-26 | 1993-04-16 | Dsm Nv | Werkwijze voor de bereiding van een alcohol. |
DE69230891T2 (de) * | 1991-12-11 | 2000-10-05 | Yoshitomi Pharmaceutical | Arzneimittel zur Behandlung von Autoimmunerkrankungen |
WO1994004491A1 (en) * | 1992-08-25 | 1994-03-03 | G.D. Searle & Co. | N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors |
JP2579602B2 (ja) * | 1992-10-21 | 1997-02-05 | 吉富製薬株式会社 | 2−アミノ−1,3−プロパンジオール化合物および免疫抑制剤 |
US5288751A (en) * | 1992-11-06 | 1994-02-22 | Abbott Laboratories | [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis |
GB9304589D0 (en) * | 1993-03-05 | 1993-04-21 | Erba Carlo Spa | Biologically active ureido derivatives useful as antimetastic agents |
GB9306473D0 (en) * | 1993-03-29 | 1993-05-19 | Bioglan Lab Ltd | Pharmaceutically useful compounds |
US5641783A (en) * | 1993-11-12 | 1997-06-24 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
US5837703A (en) * | 1993-03-31 | 1998-11-17 | Cell Therapeutics, Inc. | Amino-alcohol substituted cyclic compounds |
JPH06345728A (ja) | 1993-06-11 | 1994-12-20 | Nissan Chem Ind Ltd | N−置換アゾール誘導体の製造方法 |
US5717605A (en) * | 1993-10-14 | 1998-02-10 | Olympus Optical Co., Ltd. | Color classification apparatus |
US5534980A (en) * | 1994-05-31 | 1996-07-09 | Mita Industrial Co., Ltd. | Electrophotographic image forming apparatus having a charge removing means |
US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
ATE279185T1 (de) * | 1995-12-28 | 2004-10-15 | Mitsubishi Pharma Corp | 2-amino-2-(2-(4-octylphenyl)ethyl)propan-1,3-di l enthaltendes arzneimittel zur topischen anwendung zur behandlung von erkrankungen die durch eine störung des immunsystems hervorgerufen werden |
US6686353B1 (en) * | 1996-05-20 | 2004-02-03 | Teijin Intellectual Property Center Limited | Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists |
US6476004B1 (en) * | 1996-07-18 | 2002-11-05 | Mitsubishi Pharma Corporation | Pharmaceutical composition |
JPH11209277A (ja) | 1998-01-19 | 1999-08-03 | Yoshitomi Pharmaceut Ind Ltd | 医薬組成物 |
EP0923539B1 (en) * | 1996-07-22 | 2002-06-05 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US6077954A (en) * | 1996-08-01 | 2000-06-20 | Isis Pharmaceuticals, Inc. | Substituted heterocyclic compounds |
WO1998015278A1 (en) | 1996-10-07 | 1998-04-16 | Smithkline Beecham Corporation | Method for stimulating bone formation |
US5891892A (en) * | 1996-10-29 | 1999-04-06 | Warner-Lambert Company | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme |
GB9624038D0 (en) | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
US5732218A (en) * | 1997-01-02 | 1998-03-24 | Lucent Technologies Inc. | Management-data-gathering system for gathering on clients and servers data regarding interactions between the servers, the clients, and users of the clients during real use of a network of clients and servers |
DK0990440T3 (da) * | 1997-02-27 | 2009-02-23 | Novartis Ag | Farmaceutisk sammensætning indeholdende 2-amino-2[2-(4-octylphenyl)-ethyl]-propan-1,3-diol, en lecithin og et saccharid |
US6214873B1 (en) * | 1997-04-04 | 2001-04-10 | Welfide Corporation | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same |
WO1999001420A1 (fr) * | 1997-07-03 | 1999-01-14 | Taito Co., Ltd. | Procede de preparation de derives d'acide 2-aminomalonique, et intermediaires utilises dans ce procede |
AU737735B2 (en) * | 1997-08-28 | 2001-08-30 | Novartis Ag | Lymphocyte function antigen-1 antagonists |
JPH1180026A (ja) * | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
ATE293603T1 (de) * | 1997-10-14 | 2005-05-15 | Mitsubishi Pharma Corp | Piperazin-verbindungen und ihre medizinische verwendung |
DE19745904A1 (de) * | 1997-10-17 | 1999-04-22 | Hoechst Ag | Polymerstabilisierte Metallkolloid-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Katalysatoren für Brennstoffzellen |
DE19817459A1 (de) * | 1998-04-20 | 1999-10-21 | Basf Ag | Neue heterozyklische substituierte Amide, Herstellung und Anwendung |
KR20010100965A (ko) * | 1998-11-02 | 2001-11-14 | 가마꾸라 아끼오 | 피롤리딘 화합물 및 이것의 의약 용도 |
EP1457478B1 (en) * | 1998-11-11 | 2017-07-19 | Novartis AG | Production of 2-amino-2-[2-(4-alkyl-phenyl)ethyl]propane-1,3-diols |
WO2000033836A1 (en) | 1998-12-04 | 2000-06-15 | Ontogen Corporation | 5-membered heterocycles for the treatment of human diseases involving modulators of selectins |
CA2347770A1 (en) * | 1998-12-18 | 2000-06-22 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
US6525069B1 (en) * | 1998-12-18 | 2003-02-25 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
US6178821B1 (en) * | 1999-01-25 | 2001-01-30 | General Electric Company | Vibration sensing device |
EP1176140B1 (en) | 1999-02-10 | 2004-12-29 | Mitsubishi Pharma Corporation | Amide compounds and medicinal use thereof |
CN1144779C (zh) | 1999-03-11 | 2004-04-07 | 杭州中美华东制药有限公司 | 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物 |
JP4627356B2 (ja) | 1999-06-30 | 2011-02-09 | 松森 昭 | ウイルス性心筋炎の予防または治療薬剤 |
AU6497200A (en) | 1999-07-30 | 2001-02-19 | Vertex Pharmaceuticals Incorporated | Acyclic and cyclic amine derivatives |
US6462092B1 (en) * | 1999-09-23 | 2002-10-08 | G.D. Searle & Co. | Use of substituted N, N-disubstituted reverse aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity |
DE19963174A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Pyrrol-Mannichbasen |
WO2001049685A2 (en) | 1999-12-31 | 2001-07-12 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6803375B1 (en) | 2000-01-06 | 2004-10-12 | The Regents Of The University Of California | Non-peptide inhibition of T-lymphocyte activation and therapies related thereto |
CN1450999A (zh) * | 2000-03-31 | 2003-10-22 | 辉瑞产品公司 | 新的哌嗪衍生物 |
US6964676B1 (en) * | 2000-04-14 | 2005-11-15 | Scimed Life Systems, Inc. | Stent securement system |
CN100374416C (zh) * | 2000-04-28 | 2008-03-12 | 霍夫曼-拉罗奇有限公司 | 对(磺酰基)芳基和杂芳基类化合物 |
CA2413418A1 (en) * | 2000-06-21 | 2001-12-27 | Joseph B. Santella | Piperidine amides as modulators of chemokine receptor activity |
JP2002053575A (ja) | 2000-08-09 | 2002-02-19 | Sankyo Co Ltd | アミノアルコ−ル類 |
DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
DE10048714A1 (de) * | 2000-09-30 | 2002-04-11 | Gruenenthal Gmbh | 5-Amino-1-penlen-3-ol-Derivate |
CA2435739A1 (en) | 2001-02-22 | 2002-09-06 | Novartis Ag | Use of accelerated lymphocyte homing agents for the manufacture of a medicament for the treatment of delayed graft function |
JP2002316985A (ja) | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | ベンゾチオフェン誘導体 |
CN1236831C (zh) | 2001-05-21 | 2006-01-18 | 茵捷特数码浮质有限公司 | 用于经肺部途径递送蛋白质的组合物 |
GB0117921D0 (en) | 2001-07-23 | 2001-09-12 | Novartis Ag | Organic compounds |
GB0119172D0 (en) | 2001-08-06 | 2001-09-26 | Melacure Therapeutics Ab | Phenyl pyrrole derivatives |
EP1431275B1 (en) | 2001-09-27 | 2010-04-07 | Kyorin Pharmaceutical Co., Ltd. | Diaryl ether derivative, addition salt thereof, and immunosuppressant |
AU2002332289B2 (en) | 2001-09-27 | 2007-05-10 | Kyorin Pharmaceutical Co., Ltd. | Diaryl sulfide derivative, addition salt thereof, and immunosuppressant |
GB0125443D0 (en) | 2001-10-23 | 2001-12-12 | Novartis Ag | Organic Compounds |
US7361671B2 (en) | 2001-11-15 | 2008-04-22 | The Institute For Pharmaceutical Discovery, Inc. | Substituted heteroarylalkanoic acids |
JP2005511735A (ja) * | 2001-12-06 | 2005-04-28 | イーラン ファーマスーティカルズ、インコーポレイテッド | 置換ヒドロキシエチルアミン |
PL211954B1 (pl) * | 2002-01-11 | 2012-07-31 | Sankyo Co | Związek, kompozycja farmaceutyczna oraz zastosowanie kompozycji farmaceutycznej |
JP2003267974A (ja) | 2002-01-11 | 2003-09-25 | Sankyo Co Ltd | アミノアルコ−ル誘導体を含有する医薬組成物 |
US20040058894A1 (en) * | 2002-01-18 | 2004-03-25 | Doherty George A. | Selective S1P1/Edg1 receptor agonists |
MXPA04011384A (es) | 2002-05-16 | 2005-02-14 | Novartis Ag | Uso de agentes de union del receptor edg en cancer. |
EP1539674A1 (en) | 2002-09-13 | 2005-06-15 | Novartis AG | Amino-propanol derivatives |
MXPA05003254A (es) | 2002-09-24 | 2005-06-08 | Novartis Ag | Agonistas del receptor de esfingosina-1-fosfato en el tratamiento de trastornos de desmielinacion. |
AU2005215320B2 (en) * | 2004-02-24 | 2008-04-17 | Sankyo Company, Limited | Amino alcohol compound |
TW200611687A (en) * | 2004-07-29 | 2006-04-16 | Sankyo Co | Pharmaceutical compositions used for immunosuppressant |
TWI418350B (zh) | 2005-06-24 | 2013-12-11 | Sankyo Co | 含有ppar調節劑之醫藥組成物的用途 |
-
2003
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- 2003-01-09 KR KR1020087006865A patent/KR20080035702A/ko not_active Application Discontinuation
- 2003-01-09 AT AT03701048T patent/ATE435202T1/de active
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- 2004-07-12 CO CO04065919A patent/CO5640126A2/es active IP Right Grant
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2006
- 2006-12-11 US US11/636,776 patent/US20070105933A1/en not_active Abandoned
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2007
- 2007-01-09 US US11/651,205 patent/US7638551B2/en not_active Expired - Fee Related
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2009
- 2009-07-24 US US12/460,884 patent/US8067396B2/en not_active Expired - Fee Related
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006068A1 (fr) * | 1994-08-22 | 1996-02-29 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose benzenique et son utilisation medicale |
WO2002006268A1 (fr) * | 2000-07-13 | 2002-01-24 | Sankyo Company, Limited | Derives d'alcool amino |
WO2002018395A1 (en) * | 2000-08-31 | 2002-03-07 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
WO2002076995A2 (en) * | 2001-03-26 | 2002-10-03 | Novartis Ag | 2-amino-propanol derivatives |
Cited By (20)
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US7560477B2 (en) | 2002-07-30 | 2009-07-14 | University Of Virginia Patent Foundation | Compounds active in sphingosine 1-phosphate signaling |
WO2005005383A1 (ja) * | 2003-07-11 | 2005-01-20 | Sankyo Company, Limited | アミノアルコール化合物 |
WO2005030848A1 (en) * | 2003-09-19 | 2005-04-07 | Dow Global Technologies Inc. | Multifunctional monomers and polyarylene compositions therefrom |
US7638637B2 (en) | 2003-11-03 | 2009-12-29 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
US7910617B2 (en) | 2004-02-24 | 2011-03-22 | Sankyo Company, Limited | Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound |
US8329676B2 (en) | 2005-02-14 | 2012-12-11 | University Of Virginia Patent Foundation | Cycloalkane-containing sphingosine 1-phosphate agonists |
US7754703B2 (en) | 2005-02-14 | 2010-07-13 | University Of Virginia Patent Foundation | Cycloalkane-containing sphingosine 1-phosphate agonists |
JPWO2006137509A1 (ja) * | 2005-06-24 | 2009-01-22 | 第一三共株式会社 | Ppar調節剤を含有する医薬組成物 |
CN101242829B (zh) * | 2005-06-24 | 2011-05-18 | 第一三共株式会社 | 含有ppar调节剂的药物组合物 |
WO2006137509A1 (ja) * | 2005-06-24 | 2006-12-28 | Daiichi Sankyo Company, Limited | Ppar調節剤を含有する医薬組成物 |
US8008286B2 (en) | 2006-01-27 | 2011-08-30 | University Of Virginia Patent Foundation | Method for treatment of neuropathic pain |
US8173710B2 (en) | 2006-02-09 | 2012-05-08 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
WO2008016133A1 (fr) | 2006-08-04 | 2008-02-07 | Daiichi Sankyo Company, Limited | Enzyme de phosphorylation d'un médicament |
US7786173B2 (en) | 2006-11-21 | 2010-08-31 | University Of Virginia Patent Foundation | Tetralin analogs having sphingosine 1-phosphate agonist activity |
US7915315B2 (en) | 2006-11-21 | 2011-03-29 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
US7964649B2 (en) | 2006-11-21 | 2011-06-21 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
WO2008146691A1 (ja) | 2007-05-25 | 2008-12-04 | Daiichi Sankyo Company, Limited | 肝炎の予防又は治療のための医薬組成物 |
WO2012073991A1 (ja) | 2010-12-02 | 2012-06-07 | 第一三共株式会社 | ピロール誘導体及びその製造方法 |
US8846943B2 (en) | 2010-12-02 | 2014-09-30 | Daiichi Sankyo Company, Limited | Pyrrole derivative and process for production thereof |
JP5728027B2 (ja) * | 2010-12-02 | 2015-06-03 | 第一三共株式会社 | ピロール誘導体及びその製造方法 |
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