DE69230891T2 - Arzneimittel zur Behandlung von Autoimmunerkrankungen - Google Patents

Arzneimittel zur Behandlung von Autoimmunerkrankungen

Info

Publication number
DE69230891T2
DE69230891T2 DE69230891T DE69230891T DE69230891T2 DE 69230891 T2 DE69230891 T2 DE 69230891T2 DE 69230891 T DE69230891 T DE 69230891T DE 69230891 T DE69230891 T DE 69230891T DE 69230891 T2 DE69230891 T2 DE 69230891T2
Authority
DE
Germany
Prior art keywords
thieno
triazolo
immunosuppression
chlorophenyl
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230891T
Other languages
English (en)
Other versions
DE69230891D1 (de
Inventor
Takeki Okumoto
Kenji Chiba
Yukio Hoshino
Hirotsugu Komatu
Mariko Nagasawa
Hidekazu Aratani
Michio Terasawa
Minoru Moriwaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Publication of DE69230891D1 publication Critical patent/DE69230891D1/de
Application granted granted Critical
Publication of DE69230891T2 publication Critical patent/DE69230891T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
DE69230891T 1991-12-11 1992-12-10 Arzneimittel zur Behandlung von Autoimmunerkrankungen Expired - Fee Related DE69230891T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP35088991 1991-12-11
JP2484892 1992-01-14
JP5438292 1992-02-04
JP12945592 1992-04-21
PCT/JP1992/001619 WO1993012117A1 (fr) 1991-12-11 1992-12-10 Agent immunosuppresseur

Publications (2)

Publication Number Publication Date
DE69230891D1 DE69230891D1 (de) 2000-05-11
DE69230891T2 true DE69230891T2 (de) 2000-10-05

Family

ID=27458207

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230891T Expired - Fee Related DE69230891T2 (de) 1991-12-11 1992-12-10 Arzneimittel zur Behandlung von Autoimmunerkrankungen

Country Status (8)

Country Link
US (1) US5686479A (de)
EP (1) EP0656361B1 (de)
AT (1) ATE191345T1 (de)
DE (1) DE69230891T2 (de)
DK (1) DK0656361T3 (de)
ES (1) ES2143993T3 (de)
GR (1) GR3033434T3 (de)
WO (1) WO1993012117A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0692483A1 (de) * 1993-03-30 1996-01-17 Yoshitomi Pharmaceutical Industries, Ltd. Zelladhäsionsinhibitor und thienotriazoldiazepin-derivat
EP0989131B1 (de) * 1996-09-13 2002-11-13 Mitsubishi Pharma Corporation Thienotriazolodiazepinverbindungen und ihre medizinischen anwendungen
WO1998053828A1 (fr) * 1997-05-27 1998-12-03 Senju Pharmaceutical Co., Ltd. Preparations aqueuses contenant de l'israpafant
JPH1180026A (ja) * 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
US6986740B2 (en) * 1998-11-02 2006-01-17 Xantech Pharmaceuticals, Inc. Ultrasound contrast using halogenated xanthenes
CA2473461C (en) * 2002-01-11 2011-11-01 Sankyo Company, Limited Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these
US7910617B2 (en) 2004-02-24 2011-03-22 Sankyo Company, Limited Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
CA2952830C (en) 2014-06-20 2022-11-01 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3777541D1 (de) * 1986-11-17 1992-04-23 Yoshitomi Pharmaceutical Paf-antagonistische thienotriazoldiazepin-verbindungen und deren pharmazeutische anwendung.
FI95708C (fi) * 1988-10-31 1996-03-11 Eisai Co Ltd Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
US5221671A (en) * 1988-10-31 1993-06-22 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
EP0368175A1 (de) * 1988-11-06 1990-05-16 Boehringer Ingelheim Kg 3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin.
EP0387613A1 (de) * 1989-03-03 1990-09-19 Boehringer Ingelheim Kg Neue Thienodiazepine
US5212185A (en) * 1992-08-14 1993-05-18 G. D. Searle & Co. Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension

Also Published As

Publication number Publication date
ES2143993T3 (es) 2000-06-01
EP0656361A4 (de) 1995-01-18
ATE191345T1 (de) 2000-04-15
GR3033434T3 (en) 2000-09-29
EP0656361A1 (de) 1995-06-07
US5686479A (en) 1997-11-11
DE69230891D1 (de) 2000-05-11
DK0656361T3 (da) 2000-07-24
WO1993012117A1 (fr) 1993-06-24
EP0656361B1 (de) 2000-04-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WELFIDE CORP., OSAKA, JP

8339 Ceased/non-payment of the annual fee