HUP0301688A2 - Aminoalkoholszármazékok, eljárás az elżállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Aminoalkoholszármazékok, eljárás az elżállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0301688A2 HUP0301688A2 HU0301688A HUP0301688A HUP0301688A2 HU P0301688 A2 HUP0301688 A2 HU P0301688A2 HU 0301688 A HU0301688 A HU 0301688A HU P0301688 A HUP0301688 A HU P0301688A HU P0301688 A2 HUP0301688 A2 HU P0301688A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- atom
- substituted
- hydrogen atom
- general formula
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 150000001414 amino alcohols Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000004434 sulfur atom Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 125000005156 substituted alkylene group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/008—Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány kiváló immunszupressziv aktivitású aminoalkohol-származékokra, ezek gyógyászatilag elfogadható sóira, észterei ésegyéb származékaira, továbbá hatóanyagként ilyen vegyületekettartalmazó gyógyászati készítményekre, a találmány szerintivegyületeknek az említett gyógyászati készítmények előállítására valóalkalmazására vonatkozik. A találmány szerinti aminoalkohol-származékokkal, illetve az ilyen vegyületeket tartalmazó gyógyászatikészítményekkel autoimmun megbetegedések megelőzhetők vagy kezelhetőkmelegvérűeknél. A találmány szerinti vegyületek (I) általánosképletében R1 és R2 azonos vagy eltérő jelentéssel hidrogénatomot vagyamino-védőcsoportot jelent; R3 jelentése hidrogénatom vagy hidroxi-védőcsoport; R4 jelentésealkilcsoport; n értéke 1 és 6 közötti egész szám; X jelentéseetiléncsoport, viniléncsoport, etiniléncsoport, -D-CH2- általánosképletű csoport (ebben az általános képletben D jelentésekarbonilcsoport, -CH(OH)- képletű csoport, oxigénatom, kénatom vagynitrogénatom) vagy adott esetben helyettesített arilcsoport; Yjelentése egyszeres kötés, adott esetben helyettesítettalkiléncsoport, az oldalláncban vagy az oldallánc végén oxigénatomotvagy kénatomot tartalmazó alkiléncsoport vagy helyettesített, aszénláncban vagy a szénlánc végén oxigénatomot vagy kénatomottartalmazó alkiléncsoport; R5 jelentése hidrogénatom,cikloalkilcsoport, arilcsoport, heterociklusos csoport, helyettesítettcikloalkilcsoport, helyettesített arilcsoport vagy helyettesítettheterociklusos csoport; R6 és R7 azonos vagy eltérő jelentésselhidrogénatomot vagy szubsztituens csoportot jelent; azzal amegkötéssel, hogy ha R5 jelentése hidrogénatom, akkor Y jelentéseegyszeres kötéstől vagy egyenes láncú, 1-10 szénatomot tartalmazóalkiléncsoporttól eltérő. Ó
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000212246 | 2000-07-13 | ||
JP2000241744 | 2000-08-09 | ||
JP2000283218 | 2000-09-19 | ||
PCT/JP2001/005988 WO2002006268A1 (fr) | 2000-07-13 | 2001-07-10 | Derives d'alcool amino |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0301688A2 true HUP0301688A2 (hu) | 2003-09-29 |
HUP0301688A3 HUP0301688A3 (en) | 2006-05-29 |
Family
ID=27344040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301688A HUP0301688A3 (en) | 2000-07-13 | 2001-07-10 | Amino alcohol derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (20)
Country | Link |
---|---|
US (2) | US6723745B2 (hu) |
EP (1) | EP1300405B1 (hu) |
KR (1) | KR100812578B1 (hu) |
CN (2) | CN1328387C (hu) |
AT (1) | ATE360011T1 (hu) |
AU (2) | AU6950301A (hu) |
BR (1) | BR0112484A (hu) |
CA (1) | CA2415678A1 (hu) |
CZ (1) | CZ200350A3 (hu) |
DE (1) | DE60127961D1 (hu) |
HK (1) | HK1051680A1 (hu) |
HU (1) | HUP0301688A3 (hu) |
IL (3) | IL153594A0 (hu) |
MX (1) | MXPA03000397A (hu) |
NO (1) | NO20030120L (hu) |
NZ (2) | NZ523554A (hu) |
PL (1) | PL359411A1 (hu) |
SK (1) | SK152003A3 (hu) |
TW (1) | TWI301833B (hu) |
WO (1) | WO2002006268A1 (hu) |
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US8882847B2 (en) | 2001-05-25 | 2014-11-11 | Conformis, Inc. | Patient selectable knee joint arthroplasty devices |
CZ200350A3 (cs) * | 2000-07-13 | 2003-05-14 | Sankyo Company Limited | Aminoalkoholové deriváty |
US7169818B2 (en) | 2000-10-03 | 2007-01-30 | University Of Virginia Patent Foundation | Lysophosphatidic acid receptor agonists and antagonists |
CA2437358A1 (en) | 2001-01-30 | 2002-08-22 | University Of Virginia Patent Foundation | Agonists and antagonists of sphingosine-1-phosphate receptors |
US7326801B2 (en) * | 2001-03-26 | 2008-02-05 | Novartis Ag | 2-amino-propanol derivatives |
KR100836547B1 (ko) * | 2002-01-11 | 2008-06-10 | 상꾜 가부시키가이샤 | 아미노 알코올 유도체 또는 포스폰산 유도체 및 이들을함유하는 의약 조성물 |
EP1478641A1 (en) * | 2002-01-24 | 2004-11-24 | Eli Lilly And Company | Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine |
ES2316758T3 (es) | 2002-05-16 | 2009-04-16 | Novartis Ag | Uso de aglutinantes del receptor edg en el cancer. |
SE0202279D0 (sv) * | 2002-07-19 | 2002-07-19 | Astrazeneca Ab | Novel comppounds |
SE0202280D0 (sv) * | 2002-07-19 | 2002-07-19 | Astrazeneca Ab | Novel compounds |
MXPA05003080A (es) | 2002-09-19 | 2005-06-15 | Kyorin Seiyaku Kk | Derivado de amino alcohol, sales de los mismos y agentes inmunosupresores. |
CN1708293A (zh) * | 2002-09-24 | 2005-12-14 | 诺瓦提斯公司 | 治疗脱髓鞘疾病的鞘氨醇-1-磷酸受体激动剂 |
US7452911B2 (en) | 2002-10-31 | 2008-11-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
CN1780594A (zh) | 2002-11-07 | 2006-05-31 | 康复米斯公司 | 用于确定半月板的大小和形状以及设计治疗的方法 |
HUE028247T2 (hu) | 2003-04-08 | 2016-12-28 | Novartis Ag | S1P receptoragonistát és cukoralkoholt tartalmazó szilárd, orális adagolású készítmény |
WO2005005383A1 (ja) * | 2003-07-11 | 2005-01-20 | Sankyo Company, Limited | アミノアルコール化合物 |
TW200505416A (en) * | 2003-08-12 | 2005-02-16 | Mitsubishi Pharma Corp | Bi-aryl compound having immunosuppressive activity |
GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
GB0329498D0 (en) | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
DE102004004719A1 (de) | 2004-01-29 | 2005-08-18 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen |
RU2332212C2 (ru) * | 2004-02-24 | 2008-08-27 | Санкио Компани, Лимитед | Аминоспирт |
TW200602337A (en) | 2004-02-25 | 2006-01-16 | Wyeth Corp | Inhibitors of protein tyrosine phosphatase 1B |
WO2005105146A1 (en) * | 2004-05-03 | 2005-11-10 | Novartis Ag | Combinations comprising a s1p receptor agonist and a jak3 kinase inhibitor |
WO2005115150A2 (en) | 2004-05-06 | 2005-12-08 | University Of Virginia Patent Foundation | Novel lysophosphatidic acid receptor selective antagonists |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
ATE502630T1 (de) | 2004-07-16 | 2011-04-15 | Kyorin Seiyaku Kk | Verfahren zur effektiven anwendung eines medikaments und verfahren zur prävention von nebenwirkungen |
TW200611687A (en) * | 2004-07-29 | 2006-04-16 | Sankyo Co | Pharmaceutical compositions used for immunosuppressant |
PT1773307E (pt) | 2004-07-30 | 2015-01-14 | Novartis Ag | Formulações de compostos à base de 2-amino-1,3- propanodiol |
US7119211B2 (en) * | 2004-09-23 | 2006-10-10 | Yamakawa Chemical Industry Co., Ltd. | Process for preparing optically active 3-(methylamino)-1-(2-thienyl) propan-1-ol and intermediates for preparation |
EP2511262B1 (en) * | 2004-10-12 | 2017-02-01 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride |
MX2007006373A (es) | 2004-11-29 | 2007-06-20 | Novartis Ag | Regimen de dosificacion de un agonista del receptor s1p. |
GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
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WO2007043433A1 (ja) * | 2005-10-07 | 2007-04-19 | Kyorin Pharmaceutical Co., Ltd. | 2-アミノ-1,3-プロパンジオール誘導体を有効成分とする肝臓疾患治療剤および肝臓疾患治療方法 |
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GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
TW200815600A (en) | 2006-08-04 | 2008-04-01 | Daiichi Sankyo Co Ltd | An enzyme for phosphorizing a medicine |
MY146775A (en) * | 2006-08-08 | 2012-09-28 | Kyorin Seiyaku Kk | Amino alcohol derivative and immunosuppressive agent having same as an active ingredient |
RU2430925C2 (ru) * | 2006-08-08 | 2011-10-10 | Киорин Фармасьютикал Ко., Лтд. | Производное аминофосфата и модулятор рецептора s1p, содержащий его в качестве активного ингредиента |
EP2086514A2 (en) | 2006-09-26 | 2009-08-12 | Novartis Ag | Pharmaceutical compositions comprising an s1p modulator |
TW200906389A (en) * | 2007-05-25 | 2009-02-16 | Daiichi Sankyo Co Ltd | Pharmaceutical composition comprising of therapeutic or prophylactic agents for hepatitis |
MY159358A (en) | 2007-10-12 | 2016-12-30 | Novartis Ag | Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators |
JP5452237B2 (ja) | 2008-02-07 | 2014-03-26 | 杏林製薬株式会社 | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
CN103396346A (zh) * | 2008-05-19 | 2013-11-20 | 杏林制药株式会社 | 光学活性氨基醇衍生物的制备方法 |
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DE2817494A1 (de) * | 1977-05-03 | 1978-11-09 | Continental Pharma | Aminoalkohol-derivat |
US4638070A (en) * | 1978-12-21 | 1987-01-20 | Continental Pharma | Heterocyclic amino-alcohol derivatives |
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CZ200350A3 (cs) | 2000-07-13 | 2003-05-14 | Sankyo Company Limited | Aminoalkoholové deriváty |
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-
2001
- 2001-07-10 CZ CZ200350A patent/CZ200350A3/cs unknown
- 2001-07-10 EP EP01947965A patent/EP1300405B1/en not_active Expired - Lifetime
- 2001-07-10 SK SK15-2003A patent/SK152003A3/sk not_active Application Discontinuation
- 2001-07-10 IL IL15359401A patent/IL153594A0/xx active IP Right Grant
- 2001-07-10 CN CNB2005100590917A patent/CN1328387C/zh not_active Expired - Fee Related
- 2001-07-10 MX MXPA03000397A patent/MXPA03000397A/es active IP Right Grant
- 2001-07-10 KR KR1020037000413A patent/KR100812578B1/ko not_active IP Right Cessation
- 2001-07-10 CA CA002415678A patent/CA2415678A1/en not_active Abandoned
- 2001-07-10 DE DE60127961T patent/DE60127961D1/de not_active Expired - Lifetime
- 2001-07-10 NZ NZ523554A patent/NZ523554A/xx unknown
- 2001-07-10 WO PCT/JP2001/005988 patent/WO2002006268A1/ja active IP Right Grant
- 2001-07-10 HU HU0301688A patent/HUP0301688A3/hu unknown
- 2001-07-10 BR BR0112484-6A patent/BR0112484A/pt not_active IP Right Cessation
- 2001-07-10 AU AU6950301A patent/AU6950301A/xx active Pending
- 2001-07-10 CN CNB018153402A patent/CN1267429C/zh not_active Expired - Fee Related
- 2001-07-10 AT AT01947965T patent/ATE360011T1/de not_active IP Right Cessation
- 2001-07-10 NZ NZ533997A patent/NZ533997A/en unknown
- 2001-07-10 PL PL01359411A patent/PL359411A1/xx unknown
- 2001-07-10 AU AU2001269503A patent/AU2001269503B2/en not_active Ceased
- 2001-07-12 TW TW090117073A patent/TWI301833B/zh active
-
2002
- 2002-12-22 IL IL153594A patent/IL153594A/en not_active IP Right Cessation
-
2003
- 2003-01-07 US US10/337,702 patent/US6723745B2/en not_active Expired - Fee Related
- 2003-01-10 NO NO20030120A patent/NO20030120L/no not_active Application Discontinuation
- 2003-05-06 HK HK03103214A patent/HK1051680A1/xx not_active IP Right Cessation
- 2003-11-20 US US10/718,858 patent/US6964976B2/en not_active Expired - Fee Related
-
2006
- 2006-03-30 IL IL174664A patent/IL174664A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
ATE360011T1 (de) | 2007-05-15 |
CN1328387C (zh) | 2007-07-25 |
HUP0301688A3 (en) | 2006-05-29 |
DE60127961D1 (de) | 2007-05-31 |
NZ533997A (en) | 2005-11-25 |
US20040132784A1 (en) | 2004-07-08 |
KR20030047988A (ko) | 2003-06-18 |
KR100812578B1 (ko) | 2008-03-13 |
HK1051680A1 (en) | 2003-08-15 |
EP1300405B1 (en) | 2007-04-18 |
AU6950301A (en) | 2002-01-30 |
US6723745B2 (en) | 2004-04-20 |
CN1680563A (zh) | 2005-10-12 |
TWI301833B (en) | 2008-10-11 |
BR0112484A (pt) | 2003-09-23 |
NO20030120L (no) | 2003-03-11 |
IL153594A0 (en) | 2003-07-06 |
NZ523554A (en) | 2004-12-24 |
CA2415678A1 (en) | 2003-01-10 |
NO20030120D0 (no) | 2003-01-10 |
CN1267429C (zh) | 2006-08-02 |
IL174664A0 (en) | 2006-08-20 |
EP1300405A1 (en) | 2003-04-09 |
EP1300405A4 (en) | 2004-04-21 |
US20030236297A1 (en) | 2003-12-25 |
PL359411A1 (en) | 2004-08-23 |
MXPA03000397A (es) | 2003-05-27 |
US6964976B2 (en) | 2005-11-15 |
CN1494540A (zh) | 2004-05-05 |
SK152003A3 (en) | 2004-07-07 |
WO2002006268A1 (fr) | 2002-01-24 |
AU2001269503B2 (en) | 2005-02-17 |
CZ200350A3 (cs) | 2003-05-14 |
IL153594A (en) | 2008-04-13 |
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