RU94046317A - Новое синтетическое промежуточное соединение для получения производных и способы получения производных аминокислот - Google Patents

Новое синтетическое промежуточное соединение для получения производных и способы получения производных аминокислот

Info

Publication number
RU94046317A
RU94046317A RU94046317/04A RU94046317A RU94046317A RU 94046317 A RU94046317 A RU 94046317A RU 94046317/04 A RU94046317/04 A RU 94046317/04A RU 94046317 A RU94046317 A RU 94046317A RU 94046317 A RU94046317 A RU 94046317A
Authority
RU
Russia
Prior art keywords
intermediate compound
lower alkyl
amino acid
ris
acid derivatives
Prior art date
Application number
RU94046317/04A
Other languages
English (en)
Inventor
Кагара Кодзи
Jp]
Каваи Нобутака
Матия Кодзи
Фурутера Тецуо
Накамура Такаси
Омори Хироки
Original Assignee
Фудзисава Фармасьютикал Ко.
Фудзисава Фармасьютикал Ко., Лтд.
Лтд. (Jp)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP4175806A external-priority patent/JPH0616645A/ja
Priority claimed from JP4323483A external-priority patent/JPH06172318A/ja
Application filed by Фудзисава Фармасьютикал Ко., Фудзисава Фармасьютикал Ко., Лтд., Лтд. (Jp) filed Critical Фудзисава Фармасьютикал Ко.
Publication of RU94046317A publication Critical patent/RU94046317A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предлагаются новое синтетическое промежуточное соединение II, пригодное для получения соединения I, проявляющего ренинингибирующую активность, и способ получения соединения I с использованием указанного промежуточного соединения II, приведенный в описании. Способ получения через промежуточное соединение II промышленно выгоден тем, что он дает возможность получать конечный продукт I с высоким выходом из более дешевых исходных материалов по сравнению с традиционными способами, может обеспечивать заметное снижение затрат на получение.

Claims (1)

  1. Предлагаются новое синтетическое промежуточное соединение II, пригодное для получения соединения I, проявляющего ренинингибирующую активность, и способ получения соединения I с использованием указанного промежуточного соединения II, приведенный в описании. Способ получения через промежуточное соединение II промышленно выгоден тем, что он дает возможность получать конечный продукт I с высоким выходом из более дешевых исходных материалов по сравнению с традиционными способами, может обеспечивать заметное снижение затрат на получение.
RU94046317/04A 1992-07-02 1993-06-28 Новое синтетическое промежуточное соединение для получения производных и способы получения производных аминокислот RU94046317A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP175806/1992 1992-07-02
JP4175806A JPH0616645A (ja) 1992-07-02 1992-07-02 新規合成中間体およびアミノ酸誘導体の製造法
JP4323483A JPH06172318A (ja) 1992-12-02 1992-12-02 新規合成中間体およびアミノ酸誘導体の製造法
JP323483/1992 1992-12-02

Publications (1)

Publication Number Publication Date
RU94046317A true RU94046317A (ru) 1996-10-20

Family

ID=26496957

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046317/04A RU94046317A (ru) 1992-07-02 1993-06-28 Новое синтетическое промежуточное соединение для получения производных и способы получения производных аминокислот

Country Status (9)

Country Link
US (1) US5523410A (ru)
EP (1) EP0648747A4 (ru)
KR (1) KR950702188A (ru)
CN (1) CN1089604A (ru)
CA (1) CA2139362A1 (ru)
HU (1) HUT70049A (ru)
MX (1) MX9303933A (ru)
RU (1) RU94046317A (ru)
WO (1) WO1994001409A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3134936B2 (ja) * 1992-10-16 2001-02-13 沖電気工業株式会社 衝撃センサ
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7879840B2 (en) * 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
AU2004220548A1 (en) 2003-03-07 2004-09-23 The Trustees Of Columbia University, In The City Of New York Type 1 ryanodine receptor-based methods
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
CN105237525A (zh) * 2015-10-29 2016-01-13 张家港阿拉宁生化技术有限公司 一种α-N-甲基组氨酸中间体及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921855A (en) * 1987-06-22 1990-05-01 Fujisawa Pharmaceutical Co., Ltd. New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same
JPH02243674A (ja) * 1989-02-17 1990-09-27 Fujisawa Pharmaceut Co Ltd アミノ酸誘導体、その製造法およびそれを含有する医薬組成物
EP0396065A1 (en) * 1989-05-02 1990-11-07 Japan Tobacco Inc. Novel amino acid derivatives possessing renin-inhibitory activities
CA2075771A1 (en) * 1991-08-12 1993-02-13 Paul Van Eikeren Enzymatic synthesis of renin inhibitors
WO1994006755A1 (en) * 1992-09-18 1994-03-31 Japan Tobacco Inc. Alcohol derivative having renin-inhibiting activity and use thereof

Also Published As

Publication number Publication date
WO1994001409A1 (en) 1994-01-20
MX9303933A (es) 1994-02-28
EP0648747A4 (en) 1996-07-31
CA2139362A1 (en) 1994-01-20
EP0648747A1 (en) 1995-04-19
US5523410A (en) 1996-06-04
HUT70049A (en) 1995-09-28
HU9403793D0 (en) 1995-02-28
CN1089604A (zh) 1994-07-20
KR950702188A (ko) 1995-06-19

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