ES2052881T3 - Agentes reductores de la presion sanguinea. - Google Patents

Agentes reductores de la presion sanguinea.

Info

Publication number
ES2052881T3
ES2052881T3 ES89200661T ES89200661T ES2052881T3 ES 2052881 T3 ES2052881 T3 ES 2052881T3 ES 89200661 T ES89200661 T ES 89200661T ES 89200661 T ES89200661 T ES 89200661T ES 2052881 T3 ES2052881 T3 ES 2052881T3
Authority
ES
Spain
Prior art keywords
blood pressure
pressure reducing
reducing agents
derivatives
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89200661T
Other languages
English (en)
Inventor
Raymond Mathieu Xhonneux
Lommen Guy Rosalia Eugene Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22629045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2052881(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2052881T3 publication Critical patent/ES2052881T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

LA INVENCION SE REFIERE A DERIVADOS DE (IMINOBISMETILEN) BIS (3,4 - DIHIDRO - 2H - 1 - BENZOPIRAN - 2 - METANOL) DE FORMULA (I), CAPAZ DE POTENCIAR LOS EFECTOS DE AGENTES REDUCTORES DE LA POSICION SANGUINEA Y A ALGUNOS DE ESTOS COMPUESTOS QUE SON NUEVOS. TAMBIEN SE REFIERE A COMPOSICIONES QUE CONTIENEN DICHOS DERIVADOS, A UN AGENTE REDUCTOR DE LA PRESION SANGUINEA Y A COMPOSICIONES QUE CONTIENEN LOS NUEVOS COMPUESTOS, ASI COMO A PROCESOS PARA PREPARAR LAS CITADAS COMPOSICIONES Y NUEVOS COMPUESTOS.
ES89200661T 1988-03-23 1989-03-16 Agentes reductores de la presion sanguinea. Expired - Lifetime ES2052881T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17274788A 1988-03-23 1988-03-23

Publications (1)

Publication Number Publication Date
ES2052881T3 true ES2052881T3 (es) 1994-07-16

Family

ID=22629045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89200661T Expired - Lifetime ES2052881T3 (es) 1988-03-23 1989-03-16 Agentes reductores de la presion sanguinea.

Country Status (19)

Country Link
EP (1) EP0334429B1 (es)
JP (1) JPH0637487B2 (es)
KR (1) KR970011287B1 (es)
AU (1) AU621591B2 (es)
CA (1) CA1337432C (es)
CY (1) CY1802A (es)
DE (2) DE68903516C5 (es)
DK (1) DK174422B1 (es)
ES (1) ES2052881T3 (es)
GR (1) GR3006972T3 (es)
HK (1) HK123594A (es)
HU (1) HU211539A9 (es)
IE (1) IE62159B1 (es)
IL (1) IL89691A (es)
LU (1) LU88842I2 (es)
NL (1) NL950031I2 (es)
NZ (1) NZ228321A (es)
PT (1) PT90095B (es)
ZA (1) ZA892179B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
CA2207333C (en) * 1994-12-28 2006-10-17 Janssen Pharmaceutica, Naamloze Vennootschap Use of nebivolol as an anti-atherogenic
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
DE69942009D1 (de) 1998-10-15 2010-03-25 Imp Innovations Ltd Verbindungen für die behandlung von gewichtsverlust
JP2004528337A (ja) 2001-05-02 2004-09-16 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化ネビボロール、ならびにその代謝産物、組成物、および使用方法
DE602005007339D1 (de) * 2004-07-30 2008-07-17 Torrent Pharmaceuticals Ltd Nebivolol und dessen pharmazeutisch unbedenkliche salze, herstellungsverfahren und pharmazeutische zusammensetzungen von nebivolol
PL1776354T3 (pl) * 2004-08-11 2010-09-30 Hetero Drugs Ltd Nowy sposób wytwarzania związków pośrednich nebiwololu
CN100341866C (zh) * 2004-08-30 2007-10-10 中国科学院理化技术研究所 α，α’－[亚氨基二（亚甲基）]－双－（6－氟－3，4－二氢－2H－1－苯并吡喃－2－甲醇）甲烷磺酸盐的合成方法
EP1866323B1 (en) * 2005-01-31 2017-05-31 Mylan Laboratories, Inc Glucuronidated nebivolol
SG175477A1 (en) * 2005-01-31 2011-11-28 Mylan Lab Inc Hydroxylated nebivolol metabolites
CN100546987C (zh) * 2005-03-03 2009-10-07 浙江医药股份有限公司新昌制药厂 Dl-奈必洛尔及其盐酸盐的制备方法
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
EP1973895A1 (en) 2006-01-18 2008-10-01 Hetero Drugs Limited Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) * 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
PL2102196T3 (pl) * 2006-11-27 2012-12-31 Zach System Spa Sposób wytwarzania nebiwololu
PT2228374E (pt) * 2006-11-27 2013-09-04 Zach System Spa Formato de nebivolol
GB0624282D0 (en) 2006-12-05 2007-01-10 Cavalla David Treatment of cachexia
US20100137424A1 (en) 2007-01-22 2010-06-03 Mostafa Akbarieh Pharmaceutical compositions comprising nebivolol or a nebivolol analogue
CN101463024B (zh) 2007-12-21 2011-06-08 上海现代制药股份有限公司 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
CN101531651B (zh) * 2008-03-13 2011-05-04 四川大学 光学活性3,4-二氢-2h-1-苯并吡喃-2-羧酸和3,4-二氢-4-氧-2h-1-苯并吡喃-2-羧酸类化合物的制备方法
ITMI20080547A1 (it) * 2008-03-31 2009-10-01 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
US8785664B2 (en) 2010-02-11 2014-07-22 Menarini International Operations Luxembourg S.A. Process for the preparation of nebivolol
IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
ITRM20110418A1 (it) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
WO2014111903A2 (en) 2013-01-21 2014-07-24 Cadila Pharmaceuticals Limited A process for the preparation of 6-fluoro-3,4-dihydro-2h-chromene- 2-carbaldehyde
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
ES2700973T3 (es) 2014-02-14 2019-02-20 Corden Pharma Int Gmbh Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
CN107531662B (zh) 2015-05-19 2021-08-06 浙江奥翔药业股份有限公司 奈必洛尔的合成方法及其中间体化合物
CN105085499B (zh) * 2015-08-07 2018-09-25 上海现代制药海门有限公司 盐酸奈必洛尔中间体混合物的结晶分离方法
ITUB20160227A1 (it) 2016-01-21 2017-07-21 Menarini Int Operations Luxembourg Sa Processo per la sintesi di intermedi di Nebivololo

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol

Also Published As

Publication number Publication date
NZ228321A (en) 1991-02-26
EP0334429A1 (en) 1989-09-27
DK146289A (da) 1989-09-24
KR970011287B1 (ko) 1997-07-09
HK123594A (en) 1994-11-18
IE890906L (en) 1989-09-23
IE62159B1 (en) 1994-12-28
AU621591B2 (en) 1992-03-19
ZA892179B (en) 1990-11-28
IL89691A0 (en) 1989-09-28
PT90095A (pt) 1989-11-10
JPH01283220A (ja) 1989-11-14
LU88842I2 (fr) 1997-01-27
DE68903516T2 (de) 1993-04-01
KR890014510A (ko) 1989-10-24
IL89691A (en) 1994-04-12
GR3006972T3 (es) 1993-06-30
DE68903516C5 (de) 2017-07-13
CA1337432C (en) 1995-10-24
PT90095B (pt) 1994-11-30
AU3074289A (en) 1989-09-28
JPH0637487B2 (ja) 1994-05-18
DK146289D0 (da) 1989-03-22
NL950031I1 (es) 1996-02-01
NL950031I2 (nl) 1997-01-06
DE68903516D1 (de) 1992-12-24
DK174422B1 (da) 2003-02-24
CY1802A (en) 1995-02-17
DE19675037I1 (de) 2003-09-04
EP0334429B1 (en) 1992-11-19
HU211539A9 (en) 1995-12-28

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