DK146289A - Fremgangsmaade til saenkning af blodtrykket - Google Patents

Fremgangsmaade til saenkning af blodtrykket

Info

Publication number
DK146289A
DK146289A DK146289A DK146289A DK146289A DK 146289 A DK146289 A DK 146289A DK 146289 A DK146289 A DK 146289A DK 146289 A DK146289 A DK 146289A DK 146289 A DK146289 A DK 146289A
Authority
DK
Denmark
Prior art keywords
procedures
reducing
blood pressure
blood
pressure
Prior art date
Application number
DK146289A
Other languages
English (en)
Other versions
DK146289D0 (da
DK174422B1 (da
Inventor
Raymond Mathieu Xhonneux
Guy Rosalia Eugene Van Lommen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22629045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK146289(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK146289D0 publication Critical patent/DK146289D0/da
Publication of DK146289A publication Critical patent/DK146289A/da
Application granted granted Critical
Publication of DK174422B1 publication Critical patent/DK174422B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
DK198901462A 1988-03-23 1989-03-22 Midler til sænkning af blodtrykket DK174422B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17274788A 1988-03-23 1988-03-23
US17274788 1988-03-23

Publications (3)

Publication Number Publication Date
DK146289D0 DK146289D0 (da) 1989-03-22
DK146289A true DK146289A (da) 1989-09-24
DK174422B1 DK174422B1 (da) 2003-02-24

Family

ID=22629045

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198901462A DK174422B1 (da) 1988-03-23 1989-03-22 Midler til sænkning af blodtrykket

Country Status (19)

Country Link
EP (1) EP0334429B1 (da)
JP (1) JPH0637487B2 (da)
KR (1) KR970011287B1 (da)
AU (1) AU621591B2 (da)
CA (1) CA1337432C (da)
CY (1) CY1802A (da)
DE (2) DE68903516C5 (da)
DK (1) DK174422B1 (da)
ES (1) ES2052881T3 (da)
GR (1) GR3006972T3 (da)
HK (1) HK123594A (da)
HU (1) HU211539A9 (da)
IE (1) IE62159B1 (da)
IL (1) IL89691A (da)
LU (1) LU88842I2 (da)
NL (1) NL950031I2 (da)
NZ (1) NZ228321A (da)
PT (1) PT90095B (da)
ZA (1) ZA892179B (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
SK282144B6 (sk) * 1994-12-28 2001-11-06 Janssen Pharmaceutica N. V. Liečivo na terapeutické a profylaktické ošetrenie degeneratívnych chorôb vaskulárneho systému a nervovej sústavy, ktoré súvisia s oxidačným stresom
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
PT1121111E (pt) 1998-10-15 2010-05-17 Imp Innovations Ltd Compostos para o tratamento de perda de peso
ATE437637T1 (de) 2001-05-02 2009-08-15 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
RU2378272C2 (ru) * 2004-07-30 2010-01-10 Торрент Фармасьютикалз Лимитед Небиволол и его фармацевтически приемлемые соли, способ их получения и фармацевтические композиции небиволола
DE602004026789D1 (de) * 2004-08-11 2010-06-02 Hetero Drugs Ltd Neues verfahren zur herstellung von nebivololzwischenprodukten
CN100341866C (zh) * 2004-08-30 2007-10-10 中国科学院理化技术研究所 α，α’－[亚氨基二（亚甲基）]－双－（6－氟－3，4－二氢－2H－1－苯并吡喃－2－甲醇）甲烷磺酸盐的合成方法
AU2006210953B2 (en) * 2005-01-31 2011-12-08 Mylan Laboratories, Inc. Glucuronidated nebivolol
AP2764A (en) 2005-01-31 2013-09-30 Mylan Lab Inc Hydroxylated nebivolol metabolites
CN100546987C (zh) * 2005-03-03 2009-10-07 浙江医药股份有限公司新昌制药厂 Dl-奈必洛尔及其盐酸盐的制备方法
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
WO2007083318A1 (en) 2006-01-18 2007-07-26 Hetero Drugs Limited Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) * 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
CN103087028B (zh) 2006-11-27 2014-12-24 Zach系统股份公司 制备奈必洛尔的方法
EP2102196B1 (en) * 2006-11-27 2012-08-01 ZaCh System S.p.A. Process for preparing nebivolol
GB0624282D0 (en) 2006-12-05 2007-01-10 Cavalla David Treatment of cachexia
CA2675538C (en) 2007-01-22 2017-02-28 Genpharm Ulc Oral pharmaceutical compositions comprising unmicronized nebivolol or a nebivolol analogue as active ingredient, and a decreased ratio of wetting agent to active ingredient
CN101463024B (zh) 2007-12-21 2011-06-08 上海现代制药股份有限公司 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
CN101531651B (zh) * 2008-03-13 2011-05-04 四川大学 光学活性3,4-二氢-2h-1-苯并吡喃-2-羧酸和3,4-二氢-4-氧-2h-1-苯并吡喃-2-羧酸类化合物的制备方法
ITMI20080547A1 (it) * 2008-03-31 2009-10-01 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
US8785664B2 (en) 2010-02-11 2014-07-22 Menarini International Operations Luxembourg S.A. Process for the preparation of nebivolol
IT1397962B1 (it) 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
IT1402974B1 (it) * 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
ITRM20110418A1 (it) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
WO2014111903A2 (en) 2013-01-21 2014-07-24 Cadila Pharmaceuticals Limited A process for the preparation of 6-fluoro-3,4-dihydro-2h-chromene- 2-carbaldehyde
EP2907809B1 (en) 2014-02-14 2018-08-22 Corden Pharma International GmbH Base-free process for the preparation of ketone intermediates usable for manufacture of nebivolol
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
EP3299364B1 (en) 2015-05-19 2021-10-20 Zhejiang Ausun Pharmaceutical Co., Ltd. Nebivolol synthesis method and intermediate compound thereof
CN105085499B (zh) * 2015-08-07 2018-09-25 上海现代制药海门有限公司 盐酸奈必洛尔中间体混合物的结晶分离方法
ITUB20160227A1 (it) 2016-01-21 2017-07-21 Menarini Int Operations Luxembourg Sa Processo per la sintesi di intermedi di Nebivololo

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol

Also Published As

Publication number Publication date
ZA892179B (en) 1990-11-28
KR970011287B1 (ko) 1997-07-09
EP0334429A1 (en) 1989-09-27
NL950031I1 (da) 1996-02-01
PT90095A (pt) 1989-11-10
LU88842I2 (fr) 1997-01-27
HK123594A (en) 1994-11-18
PT90095B (pt) 1994-11-30
AU3074289A (en) 1989-09-28
NZ228321A (en) 1991-02-26
NL950031I2 (nl) 1997-01-06
DE68903516C5 (de) 2017-07-13
GR3006972T3 (da) 1993-06-30
HU211539A9 (en) 1995-12-28
CY1802A (en) 1995-02-17
ES2052881T3 (es) 1994-07-16
JPH01283220A (ja) 1989-11-14
EP0334429B1 (en) 1992-11-19
IE62159B1 (en) 1994-12-28
DE19675037I1 (de) 2003-09-04
DK146289D0 (da) 1989-03-22
DE68903516D1 (de) 1992-12-24
AU621591B2 (en) 1992-03-19
JPH0637487B2 (ja) 1994-05-18
IL89691A0 (en) 1989-09-28
DK174422B1 (da) 2003-02-24
IE890906L (en) 1989-09-23
KR890014510A (ko) 1989-10-24
CA1337432C (en) 1995-10-24
IL89691A (en) 1994-04-12
DE68903516T2 (de) 1993-04-01

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Legal Events

Date Code Title Description
PBP Patent lapsed
CTFG Supplementary protection certificate (spc) issued

Spc suppl protection certif: CA 2003 00015

PUP Patent expired