ZA892179B - Method of lowering the blood pressure - Google Patents

Method of lowering the blood pressure

Info

Publication number
ZA892179B
ZA892179B ZA892179A ZA892179A ZA892179B ZA 892179 B ZA892179 B ZA 892179B ZA 892179 A ZA892179 A ZA 892179A ZA 892179 A ZA892179 A ZA 892179A ZA 892179 B ZA892179 B ZA 892179B
Authority
ZA
South Africa
Prior art keywords
lowering
blood pressure
blood
pressure
Prior art date
Application number
ZA892179A
Other languages
English (en)
Inventor
Raymond Mathieu Xhonneux
Mathieu Xhonneux Raymond
Guy Rosalia Eugene Van Lommen
Rosalia Eugene Van Lommen Guy
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22629045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA892179(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA892179B publication Critical patent/ZA892179B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA892179A 1988-03-23 1989-03-22 Method of lowering the blood pressure ZA892179B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17274788A 1988-03-23 1988-03-23

Publications (1)

Publication Number Publication Date
ZA892179B true ZA892179B (en) 1990-11-28

Family

ID=22629045

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA892179A ZA892179B (en) 1988-03-23 1989-03-22 Method of lowering the blood pressure

Country Status (19)

Country Link
EP (1) EP0334429B1 (da)
JP (1) JPH0637487B2 (da)
KR (1) KR970011287B1 (da)
AU (1) AU621591B2 (da)
CA (1) CA1337432C (da)
CY (1) CY1802A (da)
DE (2) DE19675037I1 (da)
DK (1) DK174422B1 (da)
ES (1) ES2052881T3 (da)
GR (1) GR3006972T3 (da)
HK (1) HK123594A (da)
HU (1) HU211539A9 (da)
IE (1) IE62159B1 (da)
IL (1) IL89691A (da)
LU (1) LU88842I2 (da)
NL (1) NL950031I2 (da)
NZ (1) NZ228321A (da)
PT (1) PT90095B (da)
ZA (1) ZA892179B (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
KR100264348B1 (ko) * 1994-12-28 2000-08-16 디르크 반테 항-죽종형성제로서 네비볼롤을 함유하는 조성물
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
EP1121111B1 (en) 1998-10-15 2010-02-10 Imperial Innovations Limited Compounds for the treatment of weight loss
DE60233140D1 (de) 2001-05-02 2009-09-10 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
MX2007000911A (es) * 2004-07-30 2007-04-12 Torrent Pharmaceuticals Ltd Nevibolol y sus sales farmaceuticamente aceptables, proceso para su preparacion y composiciones farmaceuticas de nevibolol.
WO2006016376A1 (en) * 2004-08-11 2006-02-16 Hetero Drugs Limited A novel process for preparation of nebivolol intermediates
CN100341866C (zh) * 2004-08-30 2007-10-10 中国科学院理化技术研究所 α，α’－[亚氨基二（亚甲基）]－双－（6－氟－3，4－二氢－2H－1－苯并吡喃－2－甲醇）甲烷磺酸盐的合成方法
NZ560385A (en) * 2005-01-31 2010-10-29 Mylan Lab Inc Glucuronidated nebivolol metabolites
AP2764A (en) 2005-01-31 2013-09-30 Mylan Lab Inc Hydroxylated nebivolol metabolites
CN100546987C (zh) * 2005-03-03 2009-10-07 浙江医药股份有限公司新昌制药厂 Dl-奈必洛尔及其盐酸盐的制备方法
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
EP1973895A1 (en) 2006-01-18 2008-10-01 Hetero Drugs Limited Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) * 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
BRPI0719367B8 (pt) * 2006-11-27 2021-05-25 Fis Fabbrica Italiana Sintetici Spa processo para a preparação de nebivolol, seus intermediários e usos
PL2099790T3 (pl) * 2006-11-27 2010-12-31 Zach System Spa Sposób wytwarzania nebiwololu
GB0624282D0 (en) 2006-12-05 2007-01-10 Cavalla David Treatment of cachexia
US20100137424A1 (en) 2007-01-22 2010-06-03 Mostafa Akbarieh Pharmaceutical compositions comprising nebivolol or a nebivolol analogue
CN101463024B (zh) 2007-12-21 2011-06-08 上海现代制药股份有限公司 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
CN101531651B (zh) * 2008-03-13 2011-05-04 四川大学 光学活性3,4-二氢-2h-1-苯并吡喃-2-羧酸和3,4-二氢-4-氧-2h-1-苯并吡喃-2-羧酸类化合物的制备方法
ITMI20080547A1 (it) * 2008-03-31 2009-10-01 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
US8785664B2 (en) 2010-02-11 2014-07-22 Menarini International Operations Luxembourg S.A. Process for the preparation of nebivolol
IT1397962B1 (it) * 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
IT1402974B1 (it) * 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
ITRM20110418A1 (it) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
WO2014111903A2 (en) 2013-01-21 2014-07-24 Cadila Pharmaceuticals Limited A process for the preparation of 6-fluoro-3,4-dihydro-2h-chromene- 2-carbaldehyde
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
PT2907809T (pt) 2014-02-14 2019-01-16 Corden Pharma Int Gmbh Processo sem base para a preparação de intermediários de cetona utilizáveis para fabrico de nebivolol
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
JP6847095B2 (ja) 2015-05-19 2021-03-24 チョーチアン オウスン ファーマシューティカル カンパニー リミテッド ネビボロールの合成方法及びその中間化合物
CN105085499B (zh) * 2015-08-07 2018-09-25 上海现代制药海门有限公司 盐酸奈必洛尔中间体混合物的结晶分离方法
ITUB20160227A1 (it) 2016-01-21 2017-07-21 Menarini Int Operations Luxembourg Sa Processo per la sintesi di intermedi di Nebivololo

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol

Also Published As

Publication number Publication date
HK123594A (en) 1994-11-18
DE68903516C5 (de) 2017-07-13
JPH0637487B2 (ja) 1994-05-18
DK146289D0 (da) 1989-03-22
DK174422B1 (da) 2003-02-24
LU88842I2 (fr) 1997-01-27
IE890906L (en) 1989-09-23
NZ228321A (en) 1991-02-26
DK146289A (da) 1989-09-24
GR3006972T3 (da) 1993-06-30
PT90095B (pt) 1994-11-30
EP0334429B1 (en) 1992-11-19
CA1337432C (en) 1995-10-24
CY1802A (en) 1995-02-17
DE19675037I1 (de) 2003-09-04
NL950031I2 (nl) 1997-01-06
DE68903516T2 (de) 1993-04-01
KR970011287B1 (ko) 1997-07-09
IL89691A (en) 1994-04-12
DE68903516D1 (de) 1992-12-24
IE62159B1 (en) 1994-12-28
NL950031I1 (da) 1996-02-01
PT90095A (pt) 1989-11-10
IL89691A0 (en) 1989-09-28
AU3074289A (en) 1989-09-28
JPH01283220A (ja) 1989-11-14
EP0334429A1 (en) 1989-09-27
AU621591B2 (en) 1992-03-19
ES2052881T3 (es) 1994-07-16
KR890014510A (ko) 1989-10-24
HU211539A9 (en) 1995-12-28

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