ES2098505T3 - Nuevos derivados de la talidomida, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de la talidomida, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2098505T3
ES2098505T3 ES92907730T ES92907730T ES2098505T3 ES 2098505 T3 ES2098505 T3 ES 2098505T3 ES 92907730 T ES92907730 T ES 92907730T ES 92907730 T ES92907730 T ES 92907730T ES 2098505 T3 ES2098505 T3 ES 2098505T3
Authority
ES
Spain
Prior art keywords
thalidomide
contain
pharmaceutical compositions
preparation procedure
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92907730T
Other languages
English (en)
Inventor
Kurt Prof Dr Eger
Gerhard Prof Dr Ehninger
Alfred Dr Stuhler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Application granted granted Critical
Publication of ES2098505T3 publication Critical patent/ES2098505T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE OFRECEN NUEVOS DERIVADOS DE TALIDOMIDA DE FORMULA (I), MEDICAMENTOS CONTENIENDO ESTOS COMPUESTOS, ASI COMO UN PROCEDIMIENTO PARA SU OBTENCION.
ES92907730T 1991-04-17 1992-04-08 Nuevos derivados de la talidomida, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2098505T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4112566 1991-04-17

Publications (1)

Publication Number Publication Date
ES2098505T3 true ES2098505T3 (es) 1997-05-01

Family

ID=6429810

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92907730T Expired - Lifetime ES2098505T3 (es) 1991-04-17 1992-04-08 Nuevos derivados de la talidomida, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Country Status (11)

Country Link
EP (1) EP0580641B1 (es)
JP (1) JP3204972B2 (es)
AT (1) ATE146787T1 (es)
AU (1) AU661299B2 (es)
CA (1) CA2104776C (es)
DE (2) DE59207778D1 (es)
DK (1) DK0580641T3 (es)
ES (1) ES2098505T3 (es)
GR (1) GR3022175T3 (es)
HK (1) HK1005188A1 (es)
WO (1) WO1992018496A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
CZ389398A3 (cs) * 1996-05-29 1999-07-14 Prototek, Inc. Proléčiva thalidomidu a jejich použití pro modulaci funkce T-buněk
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
EP0963200B9 (en) 1996-11-05 2005-11-30 The Children's Medical Center Corporation Compositions for inhibition of angiogenesis comprising thalodomide and a nsaid
DE19703763C1 (de) * 1997-02-01 1998-10-01 Gruenenthal Gmbh Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione
DE19743968C2 (de) * 1997-10-06 2002-07-11 Gruenenthal Gmbh Intravenöse Applikationsform von Thalidomid zur Therapie immunologischer Erkrankungen
SK13642000A3 (sk) 1998-03-16 2001-04-09 Celgene Corporation 2-(2,6-dioxopiperidin-3-yl)izoindolínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
US6673828B1 (en) 1998-05-11 2004-01-06 Children's Medical Center Corporation Analogs of 2-Phthalimidinoglutaric acid
ES2194640T3 (es) 1999-03-31 2003-12-01 Gruenenthal Chemie Solucion acuosa estable del derivado de la talidomida (em 12), para su administracion parenteral, y su procedimiento de preparacion.
US7091353B2 (en) 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
CA2439410C (en) 2001-02-27 2011-09-06 William D. Figg Analogs of thalidomide as potential angiogenesis inhibitors
CN100488959C (zh) * 2003-03-27 2009-05-20 天津和美生物技术有限公司 水溶性的酞胺哌啶酮衍生物
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
US7973057B2 (en) 2003-09-17 2011-07-05 The United States Of America As Represented By The Department Of Health And Human Services Thalidomide analogs
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
NZ592425A (en) 2008-10-29 2013-04-26 Celgene Corp Isoindoline compounds for use in the treatment of cancer
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB768821A (en) * 1954-05-17 1957-02-20 Gruenenthal Chemie Novel products of the amino-piperidine-2, 6-dione series
DE1545706A1 (de) * 1965-05-08 1969-10-09 Gruenenthal Chemie Dicarbonsaeureimidderivate und Verfahren zu ihrer Herstellung
DE1670391A1 (de) * 1965-05-08 1970-11-05 Gruenenthal Chemie Dikarbonsaeureimidderivate und Verfahren zu ihrer Herstellung
DE1545672B2 (de) * 1965-05-08 1974-11-07 Chemie Gruenenthal Gmbh, 5190 Stolberg Dikarbonsäureimidderivate und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
DE4211812C2 (de) 1994-05-05
JP3204972B2 (ja) 2001-09-04
HK1005188A1 (en) 1998-12-24
DK0580641T3 (da) 1997-01-20
JPH06506671A (ja) 1994-07-28
ATE146787T1 (de) 1997-01-15
EP0580641A1 (de) 1994-02-02
AU1455592A (en) 1992-11-17
DE59207778D1 (de) 1997-02-06
CA2104776C (en) 2003-12-09
GR3022175T3 (en) 1997-03-31
EP0580641B1 (de) 1996-12-27
DE4211812A1 (de) 1992-10-22
WO1992018496A1 (de) 1992-10-29
CA2104776A1 (en) 1992-10-18
AU661299B2 (en) 1995-07-20

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