AU1455592A - New thalidomide derivatives, method of manufacture and use thereof in medicaments - Google Patents
New thalidomide derivatives, method of manufacture and use thereof in medicamentsInfo
- Publication number
- AU1455592A AU1455592A AU14555/92A AU1455592A AU1455592A AU 1455592 A AU1455592 A AU 1455592A AU 14555/92 A AU14555/92 A AU 14555/92A AU 1455592 A AU1455592 A AU 1455592A AU 1455592 A AU1455592 A AU 1455592A
- Authority
- AU
- Australia
- Prior art keywords
- medicaments
- manufacture
- thalidomide derivatives
- new
- new thalidomide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
New thalidomide derivatives of formula (I), medicaments containing those compounds, and a method for manufacturing them are disclosed.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4112566 | 1991-04-17 | ||
DE4112566 | 1991-04-17 | ||
PCT/EP1992/000790 WO1992018496A1 (en) | 1991-04-17 | 1992-04-08 | New thalidomide derivatives, method of manufacture and use thereof in medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1455592A true AU1455592A (en) | 1992-11-17 |
AU661299B2 AU661299B2 (en) | 1995-07-20 |
Family
ID=6429810
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU14555/92A Ceased AU661299B2 (en) | 1991-04-17 | 1992-04-08 | New thalidomide derivatives, method of manufacture and use thereof in medicaments |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0580641B1 (en) |
JP (1) | JP3204972B2 (en) |
AT (1) | ATE146787T1 (en) |
AU (1) | AU661299B2 (en) |
CA (1) | CA2104776C (en) |
DE (2) | DE4211812C2 (en) |
DK (1) | DK0580641T3 (en) |
ES (1) | ES2098505T3 (en) |
GR (1) | GR3022175T3 (en) |
HK (1) | HK1005188A1 (en) |
WO (1) | WO1992018496A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8143283B1 (en) | 1993-03-01 | 2012-03-27 | The Children's Medical Center Corporation | Methods for treating blood-born tumors with thalidomide |
US5629327A (en) * | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
US6114355A (en) * | 1993-03-01 | 2000-09-05 | D'amato; Robert | Methods and compositions for inhibition of angiogenesis |
DE19613976C1 (en) * | 1996-04-09 | 1997-11-20 | Gruenenthal Gmbh | Thalidomide prodrugs with immunomodulatory effects |
WO1997045117A1 (en) * | 1996-05-29 | 1997-12-04 | Prototek, Inc. | Prodrugs of thalidomide and methods for using same as modulators of t-cell function |
HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
ATE305301T1 (en) | 1996-11-05 | 2005-10-15 | Childrens Medical Center | AGENTS FOR INHIBITING ANGIOGENESIS CONTAINING THALODOMIDE AND AN NSAID |
DE19703763C1 (en) * | 1997-02-01 | 1998-10-01 | Gruenenthal Gmbh | Thalidomide-analogous compounds from the class of the piperidine-2,6-diones |
DE19743968C2 (en) * | 1997-10-06 | 2002-07-11 | Gruenenthal Gmbh | Intravenous application form of thalidomide for the therapy of immunological diseases |
CN100390163C (en) | 1998-03-16 | 2008-05-28 | 赛尔金有限公司 | 2-(2,6-dioxopiperidin-3-yl)-isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines |
US6673828B1 (en) | 1998-05-11 | 2004-01-06 | Children's Medical Center Corporation | Analogs of 2-Phthalimidinoglutaric acid |
PT1040838E (en) | 1999-03-31 | 2003-08-29 | Gruenenthal Gmbh | AQUOSA SOLUTION OF 3- (1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL) PIPERIDINE-2,6-DIONA |
US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
WO2002068414A2 (en) | 2001-02-27 | 2002-09-06 | The Governement Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Analogs of thalidomide as potential angiogenesis inhibitors |
CN100488959C (en) * | 2003-03-27 | 2009-05-20 | 天津和美生物技术有限公司 | Water soluble thalidomide derivative |
US8952895B2 (en) | 2011-06-03 | 2015-02-10 | Apple Inc. | Motion-based device operations |
CA2808646C (en) | 2003-09-17 | 2016-08-23 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Thalidomide analogs as tnf-alpha modulators |
US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
SI2358697T1 (en) | 2008-10-29 | 2016-02-29 | Celgene Corporation | Isoindoline compounds for use in the treatment of cancer. |
US8927725B2 (en) | 2011-12-02 | 2015-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB768821A (en) * | 1954-05-17 | 1957-02-20 | Gruenenthal Chemie | Novel products of the amino-piperidine-2, 6-dione series |
DE1670391A1 (en) * | 1965-05-08 | 1970-11-05 | Gruenenthal Chemie | Dicarboximide derivatives and processes for their preparation |
DE1545706A1 (en) * | 1965-05-08 | 1969-10-09 | Gruenenthal Chemie | Dicarboximide derivatives and processes for their preparation |
DE1545672B2 (en) * | 1965-05-08 | 1974-11-07 | Chemie Gruenenthal Gmbh, 5190 Stolberg | Dicarboximide derivatives and processes for their preparation |
-
1992
- 1992-04-08 ES ES92907730T patent/ES2098505T3/en not_active Expired - Lifetime
- 1992-04-08 DK DK92907730.3T patent/DK0580641T3/en active
- 1992-04-08 CA CA002104776A patent/CA2104776C/en not_active Expired - Fee Related
- 1992-04-08 JP JP50714792A patent/JP3204972B2/en not_active Expired - Fee Related
- 1992-04-08 EP EP92907730A patent/EP0580641B1/en not_active Expired - Lifetime
- 1992-04-08 AU AU14555/92A patent/AU661299B2/en not_active Ceased
- 1992-04-08 DE DE4211812A patent/DE4211812C2/en not_active Expired - Fee Related
- 1992-04-08 AT AT92907730T patent/ATE146787T1/en not_active IP Right Cessation
- 1992-04-08 DE DE59207778T patent/DE59207778D1/en not_active Expired - Fee Related
- 1992-04-08 WO PCT/EP1992/000790 patent/WO1992018496A1/en active IP Right Grant
-
1996
- 1996-12-30 GR GR960403624T patent/GR3022175T3/en unknown
-
1998
- 1998-05-19 HK HK98104297A patent/HK1005188A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GR3022175T3 (en) | 1997-03-31 |
DE4211812C2 (en) | 1994-05-05 |
DE59207778D1 (en) | 1997-02-06 |
JP3204972B2 (en) | 2001-09-04 |
AU661299B2 (en) | 1995-07-20 |
CA2104776A1 (en) | 1992-10-18 |
JPH06506671A (en) | 1994-07-28 |
HK1005188A1 (en) | 1998-12-24 |
EP0580641A1 (en) | 1994-02-02 |
DE4211812A1 (en) | 1992-10-22 |
EP0580641B1 (en) | 1996-12-27 |
ATE146787T1 (en) | 1997-01-15 |
ES2098505T3 (en) | 1997-05-01 |
DK0580641T3 (en) | 1997-01-20 |
CA2104776C (en) | 2003-12-09 |
WO1992018496A1 (en) | 1992-10-29 |
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