DK0580641T3 - Novel thalidomide derivatives, a process for their preparation and their use in pharmaceuticals - Google Patents

Novel thalidomide derivatives, a process for their preparation and their use in pharmaceuticals

Info

Publication number
DK0580641T3
DK0580641T3 DK92907730.3T DK92907730T DK0580641T3 DK 0580641 T3 DK0580641 T3 DK 0580641T3 DK 92907730 T DK92907730 T DK 92907730T DK 0580641 T3 DK0580641 T3 DK 0580641T3
Authority
DK
Denmark
Prior art keywords
pharmaceuticals
novel
preparation
thalidomide derivatives
derivatives
Prior art date
Application number
DK92907730.3T
Other languages
Danish (da)
Inventor
Kurt Prof Dr Eger
Gerhard Prof Dr Ehninger
Alfred Dr Stuhler
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK0580641T3 publication Critical patent/DK0580641T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New thalidomide derivatives of formula (I), medicaments containing those compounds, and a method for manufacturing them are disclosed.
DK92907730.3T 1991-04-17 1992-04-08 Novel thalidomide derivatives, a process for their preparation and their use in pharmaceuticals DK0580641T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4112566 1991-04-17

Publications (1)

Publication Number Publication Date
DK0580641T3 true DK0580641T3 (en) 1997-01-20

Family

ID=6429810

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92907730.3T DK0580641T3 (en) 1991-04-17 1992-04-08 Novel thalidomide derivatives, a process for their preparation and their use in pharmaceuticals

Country Status (11)

Country Link
EP (1) EP0580641B1 (en)
JP (1) JP3204972B2 (en)
AT (1) ATE146787T1 (en)
AU (1) AU661299B2 (en)
CA (1) CA2104776C (en)
DE (2) DE59207778D1 (en)
DK (1) DK0580641T3 (en)
ES (1) ES2098505T3 (en)
GR (1) GR3022175T3 (en)
HK (1) HK1005188A1 (en)
WO (1) WO1992018496A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
DE19613976C1 (en) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomide prodrugs with immunomodulatory effects
EP0914123A4 (en) * 1996-05-29 2000-10-11 Prototek Inc Prodrugs of thalidomide and methods for using same as modulators of t-cell function
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
ATE305301T1 (en) 1996-11-05 2005-10-15 Childrens Medical Center AGENTS FOR INHIBITING ANGIOGENESIS CONTAINING THALODOMIDE AND AN NSAID
DE19703763C1 (en) * 1997-02-01 1998-10-01 Gruenenthal Gmbh Thalidomide-analogous compounds from the class of the piperidine-2,6-diones
DE19743968C2 (en) * 1997-10-06 2002-07-11 Gruenenthal Gmbh Intravenous application form of thalidomide for the therapy of immunological diseases
TR200101503T2 (en) 1998-03-16 2002-06-21 Celgene Corporation 2- (2,6-dioxopiperidin-3-yl) isoindoline derivatives, their preparation and use as inhibitors of inflammatory cytokines
US6673828B1 (en) 1998-05-11 2004-01-06 Children's Medical Center Corporation Analogs of 2-Phthalimidinoglutaric acid
DK1040838T3 (en) 1999-03-31 2003-05-26 Gruenenthal Gmbh Stable aqueous solution of 3- (1-oxo-1,3-dihydroisoindol-2-yl) piperidine-2,6-dione
US7091353B2 (en) 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
EP1389203B8 (en) 2001-02-27 2010-03-10 The Governement of the United States of America, represented by The Secretary Department of Health and Human services Analogs of thalidomide as angiogenesis inhibitors
CN100488959C (en) * 2003-03-27 2009-05-20 天津和美生物技术有限公司 Water soluble thalidomide derivative
BRPI0414497A (en) 2003-09-17 2006-11-14 Us Gov Health & Human Serv thalidomide analogs
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
PE20140963A1 (en) * 2008-10-29 2014-08-06 Celgene Corp ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB768821A (en) * 1954-05-17 1957-02-20 Gruenenthal Chemie Novel products of the amino-piperidine-2, 6-dione series
DE1545706A1 (en) * 1965-05-08 1969-10-09 Gruenenthal Chemie Dicarboximide derivatives and processes for their preparation
DE1670391A1 (en) * 1965-05-08 1970-11-05 Gruenenthal Chemie Dicarboximide derivatives and processes for their preparation
DE1545672B2 (en) * 1965-05-08 1974-11-07 Chemie Gruenenthal Gmbh, 5190 Stolberg Dicarboximide derivatives and processes for their preparation

Also Published As

Publication number Publication date
DE4211812A1 (en) 1992-10-22
ATE146787T1 (en) 1997-01-15
EP0580641B1 (en) 1996-12-27
HK1005188A1 (en) 1998-12-24
CA2104776C (en) 2003-12-09
JP3204972B2 (en) 2001-09-04
DE4211812C2 (en) 1994-05-05
JPH06506671A (en) 1994-07-28
AU1455592A (en) 1992-11-17
EP0580641A1 (en) 1994-02-02
GR3022175T3 (en) 1997-03-31
AU661299B2 (en) 1995-07-20
DE59207778D1 (en) 1997-02-06
ES2098505T3 (en) 1997-05-01
CA2104776A1 (en) 1992-10-18
WO1992018496A1 (en) 1992-10-29

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