GR3022175T3 - New thalidomide derivatives, method of manufacture and use thereof in medicaments - Google Patents

New thalidomide derivatives, method of manufacture and use thereof in medicaments

Info

Publication number
GR3022175T3
GR3022175T3 GR960403624T GR960403624T GR3022175T3 GR 3022175 T3 GR3022175 T3 GR 3022175T3 GR 960403624 T GR960403624 T GR 960403624T GR 960403624 T GR960403624 T GR 960403624T GR 3022175 T3 GR3022175 T3 GR 3022175T3
Authority
GR
Greece
Prior art keywords
medicaments
manufacture
thalidomide derivatives
new
new thalidomide
Prior art date
Application number
GR960403624T
Other languages
English (en)
Inventor
Kurt Prof Dr Eger
Gerhard Prof Dr Ehninger
Alfred Dr Stuhler
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of GR3022175T3 publication Critical patent/GR3022175T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR960403624T 1991-04-17 1996-12-30 New thalidomide derivatives, method of manufacture and use thereof in medicaments GR3022175T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4112566 1991-04-17
PCT/EP1992/000790 WO1992018496A1 (de) 1991-04-17 1992-04-08 Neue thalidomidderivate, ein verfahren zu deren herstellung sowie die verwendung derselben in arzneimitteln

Publications (1)

Publication Number Publication Date
GR3022175T3 true GR3022175T3 (en) 1997-03-31

Family

ID=6429810

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960403624T GR3022175T3 (en) 1991-04-17 1996-12-30 New thalidomide derivatives, method of manufacture and use thereof in medicaments

Country Status (11)

Country Link
EP (1) EP0580641B1 (el)
JP (1) JP3204972B2 (el)
AT (1) ATE146787T1 (el)
AU (1) AU661299B2 (el)
CA (1) CA2104776C (el)
DE (2) DE59207778D1 (el)
DK (1) DK0580641T3 (el)
ES (1) ES2098505T3 (el)
GR (1) GR3022175T3 (el)
HK (1) HK1005188A1 (el)
WO (1) WO1992018496A1 (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
CA2256669A1 (en) * 1996-05-29 1997-12-04 Prototek, Inc. Prodrugs of thalidomide and methods for using same as modulators of t-cell function
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
JP2002513391A (ja) 1996-11-05 2002-05-08 ザ チルドレンズ メディカル センター コーポレイション 血管形成の抑制のための方法と組成物
DE19703763C1 (de) * 1997-02-01 1998-10-01 Gruenenthal Gmbh Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione
DE19743968C2 (de) * 1997-10-06 2002-07-11 Gruenenthal Gmbh Intravenöse Applikationsform von Thalidomid zur Therapie immunologischer Erkrankungen
EP1064277B1 (en) 1998-03-16 2005-06-15 Celgene Corporation 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines
US6673828B1 (en) 1998-05-11 2004-01-06 Children's Medical Center Corporation Analogs of 2-Phthalimidinoglutaric acid
ATE235256T1 (de) 1999-03-31 2003-04-15 Gruenenthal Gmbh Stabile wässrige lösung von 3-(1-oxo-1,3-dihydro- isoindol-2-yl)-piperidin-2,6-dion
US7091353B2 (en) 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
US7320991B2 (en) 2001-02-27 2008-01-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Analogs of thalidomide as potential angiogenesis inhibitors
CN100488959C (zh) * 2003-03-27 2009-05-20 天津和美生物技术有限公司 水溶性的酞胺哌啶酮衍生物
CA2808646C (en) 2003-09-17 2016-08-23 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Thalidomide analogs as tnf-alpha modulators
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
NZ592425A (en) * 2008-10-29 2013-04-26 Celgene Corp Isoindoline compounds for use in the treatment of cancer
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB768821A (en) * 1954-05-17 1957-02-20 Gruenenthal Chemie Novel products of the amino-piperidine-2, 6-dione series
DE1670391A1 (de) * 1965-05-08 1970-11-05 Gruenenthal Chemie Dikarbonsaeureimidderivate und Verfahren zu ihrer Herstellung
DE1545706A1 (de) * 1965-05-08 1969-10-09 Gruenenthal Chemie Dicarbonsaeureimidderivate und Verfahren zu ihrer Herstellung
DE1545672B2 (de) * 1965-05-08 1974-11-07 Chemie Gruenenthal Gmbh, 5190 Stolberg Dikarbonsäureimidderivate und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
JPH06506671A (ja) 1994-07-28
DE4211812C2 (de) 1994-05-05
DE59207778D1 (de) 1997-02-06
EP0580641B1 (de) 1996-12-27
AU1455592A (en) 1992-11-17
EP0580641A1 (de) 1994-02-02
JP3204972B2 (ja) 2001-09-04
CA2104776A1 (en) 1992-10-18
DE4211812A1 (de) 1992-10-22
ATE146787T1 (de) 1997-01-15
AU661299B2 (en) 1995-07-20
HK1005188A1 (en) 1998-12-24
DK0580641T3 (da) 1997-01-20
CA2104776C (en) 2003-12-09
WO1992018496A1 (de) 1992-10-29
ES2098505T3 (es) 1997-05-01

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