DK0580641T3 - Hidtil ukendte thalidomidderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse i lægemidler - Google Patents

Hidtil ukendte thalidomidderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse i lægemidler

Info

Publication number
DK0580641T3
DK0580641T3 DK92907730.3T DK92907730T DK0580641T3 DK 0580641 T3 DK0580641 T3 DK 0580641T3 DK 92907730 T DK92907730 T DK 92907730T DK 0580641 T3 DK0580641 T3 DK 0580641T3
Authority
DK
Denmark
Prior art keywords
pharmaceuticals
novel
preparation
thalidomide derivatives
derivatives
Prior art date
Application number
DK92907730.3T
Other languages
Danish (da)
English (en)
Inventor
Kurt Prof Dr Eger
Gerhard Prof Dr Ehninger
Alfred Dr Stuhler
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK0580641T3 publication Critical patent/DK0580641T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK92907730.3T 1991-04-17 1992-04-08 Hidtil ukendte thalidomidderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse i lægemidler DK0580641T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4112566 1991-04-17

Publications (1)

Publication Number Publication Date
DK0580641T3 true DK0580641T3 (da) 1997-01-20

Family

ID=6429810

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92907730.3T DK0580641T3 (da) 1991-04-17 1992-04-08 Hidtil ukendte thalidomidderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse i lægemidler

Country Status (11)

Country Link
EP (1) EP0580641B1 (es)
JP (1) JP3204972B2 (es)
AT (1) ATE146787T1 (es)
AU (1) AU661299B2 (es)
CA (1) CA2104776C (es)
DE (2) DE59207778D1 (es)
DK (1) DK0580641T3 (es)
ES (1) ES2098505T3 (es)
GR (1) GR3022175T3 (es)
HK (1) HK1005188A1 (es)
WO (1) WO1992018496A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
CZ389398A3 (cs) * 1996-05-29 1999-07-14 Prototek, Inc. Proléčiva thalidomidu a jejich použití pro modulaci funkce T-buněk
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
NZ336035A (en) 1996-11-05 2002-03-28 Childrens Medical Center Angiogenesis inhibitory composition comprising an inhibitory compound and antiinflammatory drug
DE19703763C1 (de) * 1997-02-01 1998-10-01 Gruenenthal Gmbh Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione
DE19743968C2 (de) * 1997-10-06 2002-07-11 Gruenenthal Gmbh Intravenöse Applikationsform von Thalidomid zur Therapie immunologischer Erkrankungen
HUP0102113A3 (en) 1998-03-16 2003-03-28 Celgene Corp Warren 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines
US6673828B1 (en) 1998-05-11 2004-01-06 Children's Medical Center Corporation Analogs of 2-Phthalimidinoglutaric acid
ATE235256T1 (de) 1999-03-31 2003-04-15 Gruenenthal Gmbh Stabile wässrige lösung von 3-(1-oxo-1,3-dihydro- isoindol-2-yl)-piperidin-2,6-dion
US7091353B2 (en) 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
JP4361273B2 (ja) 2001-02-27 2009-11-11 アメリカ合衆国 潜在的な血管形成阻害剤としてのサリドマイド類似体
CN100488959C (zh) * 2003-03-27 2009-05-20 天津和美生物技术有限公司 水溶性的酞胺哌啶酮衍生物
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
CN1867331B (zh) 2003-09-17 2010-05-26 美国政府健康及人类服务部 作为TNF-α调节剂的沙利度胺类似物
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
NZ592425A (en) * 2008-10-29 2013-04-26 Celgene Corp Isoindoline compounds for use in the treatment of cancer
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB768821A (en) * 1954-05-17 1957-02-20 Gruenenthal Chemie Novel products of the amino-piperidine-2, 6-dione series
DE1545672B2 (de) * 1965-05-08 1974-11-07 Chemie Gruenenthal Gmbh, 5190 Stolberg Dikarbonsäureimidderivate und Verfahren zu ihrer Herstellung
DE1670391A1 (de) * 1965-05-08 1970-11-05 Gruenenthal Chemie Dikarbonsaeureimidderivate und Verfahren zu ihrer Herstellung
DE1545706A1 (de) * 1965-05-08 1969-10-09 Gruenenthal Chemie Dicarbonsaeureimidderivate und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
JP3204972B2 (ja) 2001-09-04
DE59207778D1 (de) 1997-02-06
JPH06506671A (ja) 1994-07-28
ATE146787T1 (de) 1997-01-15
DE4211812A1 (de) 1992-10-22
DE4211812C2 (de) 1994-05-05
AU661299B2 (en) 1995-07-20
GR3022175T3 (en) 1997-03-31
WO1992018496A1 (de) 1992-10-29
HK1005188A1 (en) 1998-12-24
EP0580641A1 (de) 1994-02-02
CA2104776A1 (en) 1992-10-18
AU1455592A (en) 1992-11-17
EP0580641B1 (de) 1996-12-27
ES2098505T3 (es) 1997-05-01
CA2104776C (en) 2003-12-09

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