AR002247A1 - Eleuterobina y analogos de la misma y composiciones que las comprenden. - Google Patents
Eleuterobina y analogos de la misma y composiciones que las comprenden.Info
- Publication number
- AR002247A1 AR002247A1 ARP950100096A AR10009695A AR002247A1 AR 002247 A1 AR002247 A1 AR 002247A1 AR P950100096 A ARP950100096 A AR P950100096A AR 10009695 A AR10009695 A AR 10009695A AR 002247 A1 AR002247 A1 AR 002247A1
- Authority
- AR
- Argentina
- Prior art keywords
- analogs
- compositions
- eleuterobina
- same
- eleutherobine
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 229930004069 diterpene Natural products 0.000 abstract 1
- 150000004141 diterpene derivatives Chemical class 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La presente invención comprende la eleuterobina que es un diterpeno glicosilado que tiene la fórmula estructural (I), que es un agente citotóxico,y que es tóxico para los carcinomas de las células cancerosas; los análogos de la eleuterobinay composiciones que las comprenden.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/336,518 US5473057A (en) | 1994-11-09 | 1994-11-09 | Eleutherobin and analogs thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AR002247A1 true AR002247A1 (es) | 1998-03-11 |
Family
ID=23316461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP950100096A AR002247A1 (es) | 1994-11-09 | 1995-11-08 | Eleuterobina y analogos de la misma y composiciones que las comprenden. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5473057A (es) |
EP (1) | EP0790769A4 (es) |
JP (1) | JPH10508611A (es) |
KR (1) | KR970706732A (es) |
AR (1) | AR002247A1 (es) |
AU (1) | AU688177B2 (es) |
BR (1) | BR9510357A (es) |
CZ (1) | CZ288170B6 (es) |
HU (1) | HUT77882A (es) |
IL (1) | IL116190A (es) |
NO (1) | NO306347B1 (es) |
NZ (1) | NZ296728A (es) |
PL (1) | PL181693B1 (es) |
RU (1) | RU2146089C1 (es) |
WO (1) | WO1996014745A1 (es) |
ZA (1) | ZA959517B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965718A (en) * | 1997-10-24 | 1999-10-12 | The Scripps Research Institute | Analogs of sarcodictyin and eleutherobin |
AU1912299A (en) * | 1997-12-11 | 1999-06-28 | Trustees Of Columbia University In The City Of New York, The | A synthetic process toward total synthesis of eleutherubin and its analogues nduses thereof |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6066635A (en) * | 1999-03-23 | 2000-05-23 | University Of California, San Diego | Avrainvillamide, a cytotoxic marine natural product, and derivatives thereof |
CA2290316A1 (en) * | 1999-11-24 | 2001-05-24 | The University Of British Columbia | Novel source of eleutherobin and related antimitotic diterpenes |
US7238514B2 (en) * | 2001-01-05 | 2007-07-03 | William Marsh Rice University | Diterpene-producing unicellular organism |
US6946283B2 (en) * | 2001-01-05 | 2005-09-20 | William Marsh Rice University | Ginkgo biloba levopimaradiene synthase |
US7067494B2 (en) | 2001-06-22 | 2006-06-27 | The University Of British Columbia | Antimitotic eleuthesides |
JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Birドメイン結合化合物 |
WO2007131366A1 (en) | 2006-05-16 | 2007-11-22 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
AU2011214057B2 (en) | 2010-02-12 | 2016-11-17 | Pharmascience Inc. | IAP BIR domain binding compounds |
US9567643B2 (en) | 2013-10-04 | 2017-02-14 | Aptose Biosciences Inc. | Compositions and methods for treating cancers |
-
1994
- 1994-11-09 US US08/336,518 patent/US5473057A/en not_active Expired - Fee Related
-
1995
- 1995-11-01 NZ NZ296728A patent/NZ296728A/en unknown
- 1995-11-01 JP JP8515567A patent/JPH10508611A/ja not_active Ceased
- 1995-11-01 RU RU97110073A patent/RU2146089C1/ru active
- 1995-11-01 WO PCT/US1995/014155 patent/WO1996014745A1/en not_active Application Discontinuation
- 1995-11-01 AU AU41409/96A patent/AU688177B2/en not_active Ceased
- 1995-11-01 PL PL95320089A patent/PL181693B1/pl unknown
- 1995-11-01 KR KR1019970702943A patent/KR970706732A/ko not_active Application Discontinuation
- 1995-11-01 EP EP95939687A patent/EP0790769A4/en not_active Ceased
- 1995-11-01 BR BR9510357A patent/BR9510357A/pt not_active Application Discontinuation
- 1995-11-01 CZ CZ19971396A patent/CZ288170B6/cs not_active IP Right Cessation
- 1995-11-01 HU HU9801000A patent/HUT77882A/hu unknown
- 1995-11-08 AR ARP950100096A patent/AR002247A1/es not_active Application Discontinuation
- 1995-11-09 ZA ZA959517A patent/ZA959517B/xx unknown
- 1995-11-29 IL IL11619095A patent/IL116190A/xx not_active IP Right Cessation
-
1997
- 1997-05-07 NO NO972103A patent/NO306347B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL320089A1 (en) | 1997-09-15 |
CZ139697A3 (en) | 1997-09-17 |
BR9510357A (pt) | 1997-12-23 |
RU2146089C1 (ru) | 2000-03-10 |
IL116190A0 (en) | 1996-01-31 |
MX9703414A (es) | 1997-07-31 |
US5473057A (en) | 1995-12-05 |
AU4140996A (en) | 1996-06-06 |
AU688177B2 (en) | 1998-03-05 |
NO972103L (no) | 1997-05-07 |
JPH10508611A (ja) | 1998-08-25 |
ZA959517B (en) | 1996-06-20 |
IL116190A (en) | 1999-12-22 |
NZ296728A (en) | 1998-03-25 |
NO306347B1 (no) | 1999-10-25 |
PL181693B1 (pl) | 2001-09-28 |
KR970706732A (ko) | 1997-12-01 |
HUT77882A (hu) | 1998-09-28 |
NO972103D0 (no) | 1997-05-07 |
WO1996014745A1 (en) | 1996-05-23 |
EP0790769A4 (en) | 1998-10-21 |
EP0790769A1 (en) | 1997-08-27 |
CZ288170B6 (en) | 2001-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |