PT801564E - Utilizacao de nebivolol como agente anti-aterogernico - Google Patents
Utilizacao de nebivolol como agente anti-aterogernicoInfo
- Publication number
- PT801564E PT801564E PT95942209T PT95942209T PT801564E PT 801564 E PT801564 E PT 801564E PT 95942209 T PT95942209 T PT 95942209T PT 95942209 T PT95942209 T PT 95942209T PT 801564 E PT801564 E PT 801564E
- Authority
- PT
- Portugal
- Prior art keywords
- aterogernic
- nebivolol
- agent
- alpha
- chromanmethanol
- Prior art date
Links
- KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 title 1
- 229960000619 nebivolol Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94203775 | 1994-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT801564E true PT801564E (pt) | 2002-09-30 |
Family
ID=8217503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95942209T PT801564E (pt) | 1994-12-28 | 1995-12-21 | Utilizacao de nebivolol como agente anti-aterogernico |
Country Status (20)
Country | Link |
---|---|
US (2) | US5874461A (pt) |
EP (1) | EP0801564B1 (pt) |
JP (1) | JPH10511655A (pt) |
KR (1) | KR100264348B1 (pt) |
CN (1) | CN1167418C (pt) |
AT (1) | ATE214924T1 (pt) |
AU (1) | AU700364B2 (pt) |
CA (1) | CA2207333C (pt) |
CZ (1) | CZ287513B6 (pt) |
DE (1) | DE69526120T2 (pt) |
DK (1) | DK0801564T3 (pt) |
ES (1) | ES2176354T3 (pt) |
FI (1) | FI118884B (pt) |
HU (1) | HU226208B1 (pt) |
NO (1) | NO315687B1 (pt) |
NZ (1) | NZ298074A (pt) |
PT (1) | PT801564E (pt) |
SI (1) | SI0801564T1 (pt) |
SK (1) | SK282144B6 (pt) |
WO (1) | WO1996019987A1 (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1167418C (zh) * | 1994-12-28 | 2004-09-22 | 詹森药业有限公司 | 奈必洛尔作为抗动脉粥样化剂的用途 |
DE19716120A1 (de) * | 1997-04-17 | 1998-10-22 | Europ Lab Molekularbiolog | Verwendung von cholesterinsenkenden Mitteln |
US6713651B1 (en) | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
JP2000207219A (ja) * | 1999-01-18 | 2000-07-28 | Fujitsu Ten Ltd | 車載端末とセンタ―との間の通信システム、及び、通信システムに使用する車載端末 |
US6683115B2 (en) | 1999-06-02 | 2004-01-27 | Theravance, Inc. | β2-adrenergic receptor agonists |
US6593497B1 (en) | 1999-06-02 | 2003-07-15 | Theravance, Inc. | β2-adrenergic receptor agonists |
UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
CA2446064A1 (en) | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
US7491312B2 (en) * | 2002-10-30 | 2009-02-17 | Edison Pharmaceuticals, Inc. | Identifying therapeutic compounds based on their physical-chemical properties |
ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
CA2580584C (en) | 2003-09-19 | 2015-07-28 | Galileo Pharmaceuticals, Inc. | Use of alpha-tocotrienol for treatment of mitochondrial diseases |
US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
RU2378272C2 (ru) | 2004-07-30 | 2010-01-10 | Торрент Фармасьютикалз Лимитед | Небиволол и его фармацевтически приемлемые соли, способ их получения и фармацевтические композиции небиволола |
EP1848424B1 (en) * | 2005-01-31 | 2017-04-05 | Mylan Laboratories, Inc | Pharmaceutical composition comprising hydroxylated nebivolol |
CA2610152C (en) | 2005-06-01 | 2018-04-10 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
EA019675B1 (ru) | 2006-02-22 | 2014-05-30 | Эдисон Фармасьютикалз, Инк. | Редокс-активные терапевтические средства для лечения митохондриальных заболеваний и модуляции биомаркера коэнзима q |
MX2010004622A (es) | 2007-11-06 | 2010-05-20 | Edison Pharmaceuticals Inc | Derivados de 4-(p-quinonil)-2-hidroxibutanamida para tratamiento de enfermedades mitocondriales. |
WO2009091777A1 (en) * | 2008-01-15 | 2009-07-23 | Forest Laboratories Holdings Limited | Nebivolol in the treatment of sexual dysfunction |
CA2717734A1 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc | 2-substituted-p-quinone derivatives for treatment of oxidative stress diseases |
WO2010030607A1 (en) | 2008-09-10 | 2010-03-18 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
CA2740773A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
EP2379710A1 (en) * | 2008-12-19 | 2011-10-26 | Schering Corporation | Feed supplement for mammalian cell culture and methods of use |
DK2424495T3 (en) | 2009-04-28 | 2018-04-30 | Bioelectron Tech Corp | TREATMENT OF LEVERS HEREDIC OPTICAL NEUROPATHY AND DOMINANT OPTICAL ATROPHY WITH TOCOTRIENOL QUINONES |
HK1161509A2 (en) * | 2010-06-04 | 2012-07-27 | Comprehensive Drug Entpr Ltd | Oral meclizine aqueous formulations with taste flavoring agent |
US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
DE102014107132A1 (de) | 2014-05-20 | 2015-11-26 | Corden Pharma International Gmbh | Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind |
WO2016062278A1 (zh) * | 2014-10-24 | 2016-04-28 | 朗齐生物医学股份有限公司 | 内分泌疾病用药在制备抑制癌症的医药组合物中的应用 |
RU2770091C2 (ru) | 2014-12-16 | 2022-04-14 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Полиморфные и аморфные формы (r)-2-гидрокси-2-метил-4-(2,4,5-триметил-3,6-диоксоциклогекса-1,4-диенил)бутанамида |
CA3008849A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1337432C (en) * | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
TW355683B (en) * | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
CN1167418C (zh) * | 1994-12-28 | 2004-09-22 | 詹森药业有限公司 | 奈必洛尔作为抗动脉粥样化剂的用途 |
-
1995
- 1995-12-21 CN CNB951971492A patent/CN1167418C/zh not_active Expired - Lifetime
- 1995-12-21 CZ CZ19971919A patent/CZ287513B6/cs not_active IP Right Cessation
- 1995-12-21 US US08/860,238 patent/US5874461A/en not_active Expired - Lifetime
- 1995-12-21 PT PT95942209T patent/PT801564E/pt unknown
- 1995-12-21 SI SI9530591T patent/SI0801564T1/xx unknown
- 1995-12-21 EP EP95942209A patent/EP0801564B1/en not_active Expired - Lifetime
- 1995-12-21 WO PCT/EP1995/005174 patent/WO1996019987A1/en active IP Right Grant
- 1995-12-21 HU HU9800675A patent/HU226208B1/hu unknown
- 1995-12-21 DE DE69526120T patent/DE69526120T2/de not_active Expired - Lifetime
- 1995-12-21 SK SK856-97A patent/SK282144B6/sk not_active IP Right Cessation
- 1995-12-21 ES ES95942209T patent/ES2176354T3/es not_active Expired - Lifetime
- 1995-12-21 CA CA002207333A patent/CA2207333C/en not_active Expired - Fee Related
- 1995-12-21 DK DK95942209T patent/DK0801564T3/da active
- 1995-12-21 NZ NZ298074A patent/NZ298074A/xx not_active IP Right Cessation
- 1995-12-21 AU AU43477/96A patent/AU700364B2/en not_active Expired
- 1995-12-21 KR KR1019970703648A patent/KR100264348B1/ko not_active IP Right Cessation
- 1995-12-21 AT AT95942209T patent/ATE214924T1/de active
- 1995-12-21 JP JP8520223A patent/JPH10511655A/ja active Pending
-
1997
- 1997-06-26 NO NO19972980A patent/NO315687B1/no not_active IP Right Cessation
- 1997-06-27 FI FI972793A patent/FI118884B/fi not_active IP Right Cessation
-
1998
- 1998-12-21 US US09/217,728 patent/US6075046A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NO972980D0 (no) | 1997-06-26 |
FI972793A (fi) | 1997-06-27 |
SK282144B6 (sk) | 2001-11-06 |
DK0801564T3 (da) | 2002-07-15 |
FI118884B (fi) | 2008-04-30 |
US6075046A (en) | 2000-06-13 |
ES2176354T3 (es) | 2002-12-01 |
DE69526120T2 (de) | 2002-11-28 |
AU4347796A (en) | 1996-07-19 |
EP0801564B1 (en) | 2002-03-27 |
JPH10511655A (ja) | 1998-11-10 |
AU700364B2 (en) | 1999-01-07 |
KR100264348B1 (ko) | 2000-08-16 |
ATE214924T1 (de) | 2002-04-15 |
CN1171739A (zh) | 1998-01-28 |
NZ298074A (en) | 2001-01-26 |
CA2207333A1 (en) | 1996-07-04 |
EP0801564A1 (en) | 1997-10-22 |
SK85697A3 (en) | 2000-04-10 |
SI0801564T1 (en) | 2002-08-31 |
NO315687B1 (no) | 2003-10-13 |
CN1167418C (zh) | 2004-09-22 |
HUT77927A (hu) | 1998-11-30 |
CZ287513B6 (en) | 2000-12-13 |
US5874461A (en) | 1999-02-23 |
HU226208B1 (en) | 2008-06-30 |
MX9704669A (es) | 1997-09-30 |
NO972980L (no) | 1997-06-26 |
FI972793A0 (fi) | 1997-06-27 |
CA2207333C (en) | 2006-10-17 |
CZ191997A3 (cs) | 1999-01-13 |
WO1996019987A1 (en) | 1996-07-04 |
DE69526120D1 (de) | 2002-05-02 |
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