DK0801564T3 - Anvendelse af nebivolol som et antiatherogent middel - Google Patents
Anvendelse af nebivolol som et antiatherogent middelInfo
- Publication number
- DK0801564T3 DK0801564T3 DK95942209T DK95942209T DK0801564T3 DK 0801564 T3 DK0801564 T3 DK 0801564T3 DK 95942209 T DK95942209 T DK 95942209T DK 95942209 T DK95942209 T DK 95942209T DK 0801564 T3 DK0801564 T3 DK 0801564T3
- Authority
- DK
- Denmark
- Prior art keywords
- nebivolol
- alpha
- antiatherogenic
- agent
- antiatherogenic agent
- Prior art date
Links
- KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 title 1
- 230000000489 anti-atherogenic effect Effects 0.000 title 1
- 229960000619 nebivolol Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94203775 | 1994-12-28 | ||
| PCT/EP1995/005174 WO1996019987A1 (en) | 1994-12-28 | 1995-12-21 | Use of nebivolol as an anti-atherogenic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0801564T3 true DK0801564T3 (da) | 2002-07-15 |
Family
ID=8217503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95942209T DK0801564T3 (da) | 1994-12-28 | 1995-12-21 | Anvendelse af nebivolol som et antiatherogent middel |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5874461A (da) |
| EP (1) | EP0801564B1 (da) |
| JP (1) | JPH10511655A (da) |
| KR (1) | KR100264348B1 (da) |
| CN (1) | CN1167418C (da) |
| AT (1) | ATE214924T1 (da) |
| AU (1) | AU700364B2 (da) |
| CA (1) | CA2207333C (da) |
| CZ (1) | CZ287513B6 (da) |
| DE (1) | DE69526120T2 (da) |
| DK (1) | DK0801564T3 (da) |
| ES (1) | ES2176354T3 (da) |
| FI (1) | FI118884B (da) |
| HU (1) | HU226208B1 (da) |
| NO (1) | NO315687B1 (da) |
| NZ (1) | NZ298074A (da) |
| PT (1) | PT801564E (da) |
| SI (1) | SI0801564T1 (da) |
| SK (1) | SK282144B6 (da) |
| WO (1) | WO1996019987A1 (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI0801564T1 (en) * | 1994-12-28 | 2002-08-31 | Janssen Pharmaceutica N.V. | Use of nebivolol as an anti-atherogenic |
| DE19716120A1 (de) * | 1997-04-17 | 1998-10-22 | Europ Lab Molekularbiolog | Verwendung von cholesterinsenkenden Mitteln |
| US6713651B1 (en) | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6362371B1 (en) | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| JP2000207219A (ja) * | 1999-01-18 | 2000-07-28 | Fujitsu Ten Ltd | 車載端末とセンタ―との間の通信システム、及び、通信システムに使用する車載端末 |
| US6683115B2 (en) | 1999-06-02 | 2004-01-27 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6593497B1 (en) | 1999-06-02 | 2003-07-15 | Theravance, Inc. | β2-adrenergic receptor agonists |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| AU2002338528B2 (en) * | 2001-05-02 | 2008-01-24 | Nicox S.A. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
| EP1558922B1 (en) * | 2002-10-30 | 2013-02-27 | Ampere Life Sciences, Inc. | Identifying therapeutic compounds based on their physical-chemical properties |
| ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
| WO2005032544A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Treatment of mitochondrial diseases |
| US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| EP1737847B1 (en) | 2004-07-30 | 2008-06-04 | Torrent Pharmaceuticals Ltd | Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol |
| EP1848424B1 (en) * | 2005-01-31 | 2017-04-05 | Mylan Laboratories, Inc | Pharmaceutical composition comprising hydroxylated nebivolol |
| EP2471530B1 (en) | 2005-06-01 | 2017-01-11 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| CA2635280C (en) | 2006-02-22 | 2017-12-12 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| WO2009061744A2 (en) | 2007-11-06 | 2009-05-14 | Edison Pharmaceuticals, Inc. | 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| US20090181975A1 (en) * | 2008-01-15 | 2009-07-16 | Forest Laboratories Holdings Limited | Nebivolol in the treatment of sexual dysfunction |
| EP2262508B1 (en) | 2008-03-05 | 2018-10-03 | BioElectron Technology Corporation | SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| WO2010030607A1 (en) | 2008-09-10 | 2010-03-18 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| US10039722B2 (en) | 2008-10-14 | 2018-08-07 | Bioelectron Technology Corporation | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| JP5719309B2 (ja) * | 2008-12-19 | 2015-05-13 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 哺乳動物細胞培養用の栄養補助剤及び使用方法 |
| DK2424495T3 (da) | 2009-04-28 | 2018-04-30 | Bioelectron Tech Corp | Behandling af lebers arvelig optisk neuropati og dominant optisk atrofi med tocotrienol-quinoner |
| WO2011150859A1 (en) * | 2010-06-04 | 2011-12-08 | Comprehensive Drug Enterprises Ltd | Oral meclizine aqueous formulations with taste flavoring agent |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| DE102014107132A1 (de) | 2014-05-20 | 2015-11-26 | Corden Pharma International Gmbh | Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind |
| TW201615191A (zh) * | 2014-10-24 | 2016-05-01 | 朗齊生物醫學股份有限公司 | 氨氯地平藥物應用於癌症治療 |
| KR102626895B1 (ko) | 2014-12-16 | 2024-01-18 | 피티씨 테라퓨틱스, 인크. | (r)-2-하이드록시-2-메틸-4-(2,4,5-트리메틸-3,6-디옥소사이클로헥사-1,4-디에닐)부탄아미드의 다형성 및 무정형 형태 |
| WO2017106803A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337432C (en) * | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
| TW355683B (en) * | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
| SI0801564T1 (en) * | 1994-12-28 | 2002-08-31 | Janssen Pharmaceutica N.V. | Use of nebivolol as an anti-atherogenic |
-
1995
- 1995-12-21 SI SI9530591T patent/SI0801564T1/xx unknown
- 1995-12-21 CA CA002207333A patent/CA2207333C/en not_active Expired - Fee Related
- 1995-12-21 CN CNB951971492A patent/CN1167418C/zh not_active Expired - Lifetime
- 1995-12-21 AU AU43477/96A patent/AU700364B2/en not_active Expired
- 1995-12-21 AT AT95942209T patent/ATE214924T1/de active
- 1995-12-21 DK DK95942209T patent/DK0801564T3/da active
- 1995-12-21 PT PT95942209T patent/PT801564E/pt unknown
- 1995-12-21 NZ NZ298074A patent/NZ298074A/xx not_active IP Right Cessation
- 1995-12-21 SK SK856-97A patent/SK282144B6/sk not_active IP Right Cessation
- 1995-12-21 WO PCT/EP1995/005174 patent/WO1996019987A1/en active IP Right Grant
- 1995-12-21 DE DE69526120T patent/DE69526120T2/de not_active Expired - Lifetime
- 1995-12-21 EP EP95942209A patent/EP0801564B1/en not_active Expired - Lifetime
- 1995-12-21 CZ CZ19971919A patent/CZ287513B6/cs not_active IP Right Cessation
- 1995-12-21 HU HU9800675A patent/HU226208B1/hu unknown
- 1995-12-21 US US08/860,238 patent/US5874461A/en not_active Expired - Lifetime
- 1995-12-21 JP JP8520223A patent/JPH10511655A/ja active Pending
- 1995-12-21 KR KR1019970703648A patent/KR100264348B1/ko not_active IP Right Cessation
- 1995-12-21 ES ES95942209T patent/ES2176354T3/es not_active Expired - Lifetime
-
1997
- 1997-06-26 NO NO19972980A patent/NO315687B1/no not_active IP Right Cessation
- 1997-06-27 FI FI972793A patent/FI118884B/fi not_active IP Right Cessation
-
1998
- 1998-12-21 US US09/217,728 patent/US6075046A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO972980D0 (no) | 1997-06-26 |
| EP0801564B1 (en) | 2002-03-27 |
| WO1996019987A1 (en) | 1996-07-04 |
| ES2176354T3 (es) | 2002-12-01 |
| HU226208B1 (en) | 2008-06-30 |
| SI0801564T1 (en) | 2002-08-31 |
| NO972980L (no) | 1997-06-26 |
| AU4347796A (en) | 1996-07-19 |
| MX9704669A (es) | 1997-09-30 |
| PT801564E (pt) | 2002-09-30 |
| US6075046A (en) | 2000-06-13 |
| CA2207333C (en) | 2006-10-17 |
| SK282144B6 (sk) | 2001-11-06 |
| EP0801564A1 (en) | 1997-10-22 |
| CN1171739A (zh) | 1998-01-28 |
| CZ287513B6 (en) | 2000-12-13 |
| FI972793A (fi) | 1997-06-27 |
| CN1167418C (zh) | 2004-09-22 |
| KR100264348B1 (ko) | 2000-08-16 |
| ATE214924T1 (de) | 2002-04-15 |
| AU700364B2 (en) | 1999-01-07 |
| DE69526120D1 (de) | 2002-05-02 |
| CA2207333A1 (en) | 1996-07-04 |
| JPH10511655A (ja) | 1998-11-10 |
| US5874461A (en) | 1999-02-23 |
| FI118884B (fi) | 2008-04-30 |
| FI972793A0 (fi) | 1997-06-27 |
| NZ298074A (en) | 2001-01-26 |
| CZ191997A3 (cs) | 1999-01-13 |
| SK85697A3 (en) | 2000-04-10 |
| HUT77927A (hu) | 1998-11-30 |
| NO315687B1 (no) | 2003-10-13 |
| DE69526120T2 (de) | 2002-11-28 |
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