EA199700243A1 - Производное аминотетралина для лечения сердечно-сосудистых заболеваний - Google Patents

Производное аминотетралина для лечения сердечно-сосудистых заболеваний

Info

Publication number
EA199700243A1
EA199700243A1 EA199700243A EA199700243A EA199700243A1 EA 199700243 A1 EA199700243 A1 EA 199700243A1 EA 199700243 A EA199700243 A EA 199700243A EA 199700243 A EA199700243 A EA 199700243A EA 199700243 A1 EA199700243 A1 EA 199700243A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
aminothetraline
derivative
cardiovascular diseases
diisobutyroxy
Prior art date
Application number
EA199700243A
Other languages
English (en)
Other versions
EA000937B1 (ru
Inventor
Паоло Кьези
Стефано Бонграни
Роберта Радзетти
Маурицио Чивелли
Альберто Умиле
Original Assignee
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. filed Critical КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Publication of EA199700243A1 publication Critical patent/EA199700243A1/ru
Publication of EA000937B1 publication Critical patent/EA000937B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

В настоящем изобретении предложено применение 5,6-диизобутироилокси-2-метиламинотетралина для получения фармацевтических композиций для лечения заболеваний сердца, в частности застойной сердечной недостаточности.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700243A 1995-03-17 1996-03-13 Применение производных аминотетралина для лечения застойной сердечной недостаточности EA000937B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI000532A IT1275935B1 (it) 1995-03-17 1995-03-17 Derivato di aminotetralina per la terapia di malattie cardiovascolari
PCT/EP1996/001060 WO1996029065A2 (en) 1995-03-17 1996-03-13 Aminotetralin derivative for the therapy of cardiovascular diseases

Publications (2)

Publication Number Publication Date
EA199700243A1 true EA199700243A1 (ru) 1998-02-26
EA000937B1 EA000937B1 (ru) 2000-06-26

Family

ID=11370947

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700243A EA000937B1 (ru) 1995-03-17 1996-03-13 Применение производных аминотетралина для лечения застойной сердечной недостаточности

Country Status (31)

Country Link
US (2) US6013678A (ru)
EP (2) EP0814791B1 (ru)
JP (1) JPH11502211A (ru)
KR (1) KR100391143B1 (ru)
CN (1) CN1112920C (ru)
AT (1) ATE218856T1 (ru)
AU (1) AU702656B2 (ru)
BR (1) BR9607996A (ru)
CA (1) CA2215671A1 (ru)
CZ (1) CZ288488B6 (ru)
DE (1) DE69621786T2 (ru)
DK (1) DK0814791T3 (ru)
EA (1) EA000937B1 (ru)
EE (1) EE04040B1 (ru)
ES (1) ES2177769T3 (ru)
HK (2) HK1004802A1 (ru)
HU (1) HUP9801686A3 (ru)
IL (1) IL117518A (ru)
IT (1) IT1275935B1 (ru)
LT (1) LT4355B (ru)
LV (1) LV11882B (ru)
MX (1) MX9706971A (ru)
NO (1) NO317402B1 (ru)
NZ (1) NZ303993A (ru)
PL (1) PL183347B1 (ru)
PT (1) PT814791E (ru)
SI (1) SI9620036B (ru)
SK (1) SK282952B6 (ru)
TR (1) TR199700963T1 (ru)
WO (1) WO1996029065A2 (ru)
ZA (1) ZA962073B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2695157B2 (ja) * 1986-12-29 1997-12-24 松下電器産業株式会社 可変パイプラインプロセッサ
WO2000076544A1 (en) * 1996-03-13 2000-12-21 Chiesi Farmaceutici S.P.A. Aminotetralin derivative for the therapy of cardiovascular diseases
PT1183046E (pt) 1999-06-09 2003-12-31 Chiesi Farma Spa Derivado de aminotetralina para a terapia de doencas cardiovasculares
SI1183046T1 (en) * 1999-06-09 2004-02-29 Chiesi Farmaceutici S.P.A. Aminotetralin derivative for the therapy of cardiovascular diseases
IT1313583B1 (it) * 1999-07-30 2002-09-09 Chiesi Farma Spa Derivati 2-amminotetralinici per la terapia del glaucoma.
IL152751A0 (en) * 2000-05-12 2003-06-24 Chiesi Farma Spa Optically active 2-aminotetralin derivatives, the processes for the preparation thereof and the therapeutical use of pharmaceutical compositions containing them
SE0101854L (sv) * 2001-05-28 2002-11-29 Bioneris Ab Användning av en förening med en negativt laddad region av grupper för behandling av restenos.
EP1384708A1 (en) * 2002-07-26 2004-01-28 CHIESI FARMACEUTICI S.p.A. Process for the manufacture of form I of nolomirole hydrochloride
US20050101668A1 (en) * 2003-07-24 2005-05-12 Chiesi Farmaceutici S.P.A. Aminotetralin derivatives as a medicament for the treatment and prevention of myocardial ischemic conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134997A (en) * 1977-03-01 1979-01-16 University Of Iowa Research Foundation Effect of an aminotetralin derivative on coronary blood flow in infarcted hearts
SU998342A1 (ru) 1981-12-11 1983-02-23 Предприятие П/Я А-3732 Способ получени синтетического цеолита типа @
IT1218322B (it) * 1982-06-10 1990-04-12 Chiesi Farma Spa Derivati di 1,2,3,4-tetraidronaftalene,procedimento di preparazione e relative composizioni farmaceutiche

Also Published As

Publication number Publication date
HK1048060A1 (zh) 2003-03-21
LT97147A (en) 1998-02-25
ITMI950532A0 (it) 1995-03-17
DK0814791T3 (da) 2002-10-07
SK125497A3 (en) 1998-02-04
EP1216702A2 (en) 2002-06-26
IT1275935B1 (it) 1997-10-24
CA2215671A1 (en) 1996-09-26
LV11882B (en) 1998-03-20
CN1181699A (zh) 1998-05-13
PL322284A1 (en) 1998-01-19
HUP9801686A2 (hu) 1999-06-28
IL117518A0 (en) 1996-07-23
NO974267D0 (no) 1997-09-16
AU5107296A (en) 1996-10-08
BR9607996A (pt) 1998-06-23
WO1996029065A2 (en) 1996-09-26
IL117518A (en) 2001-05-20
KR100391143B1 (ko) 2003-11-28
EP0814791A1 (en) 1998-01-07
JPH11502211A (ja) 1999-02-23
CZ288488B6 (en) 2001-06-13
DE69621786D1 (de) 2002-07-18
TR199700963T1 (xx) 1998-02-21
NZ303993A (en) 2000-12-22
LV11882A (lv) 1997-12-20
NO317402B1 (no) 2004-10-25
ITMI950532A1 (it) 1996-09-17
ES2177769T3 (es) 2002-12-16
KR19980703030A (ko) 1998-09-05
WO1996029065A3 (en) 1996-11-28
EE9700231A (et) 1998-04-15
CZ286697A3 (cs) 1998-03-18
ZA962073B (en) 1996-11-27
ATE218856T1 (de) 2002-06-15
HK1004802A1 (en) 1998-12-11
NO974267L (no) 1997-11-07
EP1216702A3 (en) 2002-09-04
PT814791E (pt) 2002-10-31
AU702656B2 (en) 1999-02-25
SK282952B6 (sk) 2003-01-09
EE04040B1 (et) 2003-06-16
HUP9801686A3 (en) 1999-10-28
EA000937B1 (ru) 2000-06-26
DE69621786T2 (de) 2003-01-02
EP0814791B1 (en) 2002-06-12
PL183347B1 (pl) 2002-06-28
SI9620036B (sl) 2002-10-31
CN1112920C (zh) 2003-07-02
US6103760A (en) 2000-08-15
US6013678A (en) 2000-01-11
LT4355B (lt) 1998-06-25
MX9706971A (es) 1997-11-29
SI9620036A (sl) 1998-02-28

Similar Documents

Publication Publication Date Title
EE9900481A (et) Väikesed molekulid, mida kasutatakse põletikuliste haiguste raviks
TR199901174T2 (xx) Yeni heterosiklilmetil-ikameli pirazol t�revleri.
EA199901063A1 (ru) Пиперазиновые производные и их применение в качестве противовоспалительных агентов
EA199900494A1 (ru) Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
EE9800080A (et) (Metüülsulfonüül)fenüül-2-(5H)-furanoonid, nende kasutamine ja farmatseutilised kompositsioonid
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
ES2192839T3 (es) Timosina beta 4 oxidada.
EA200200479A1 (ru) Новые олигосахариды, их получение и содержащие их фармацевтические композиции
EA200000741A1 (ru) Новые производные дигидроксигексановой кислоты
EA199700243A1 (ru) Производное аминотетралина для лечения сердечно-сосудистых заболеваний
ATE234636T1 (de) Konjugat, umfassend einen wirkstoff, ein polypeptid und einen polyether
TR200000697T2 (tr) İkame edilmiş 1,2,3,4,5,6-Heksahidro-2,6-Metano-3-Benzazosin-10-OL'ler, üretim yöntemleri ve farmasötik preparat olarak kullanımları.
EA200300727A1 (ru) Производные 2h-1-бензопирана, способы их получения и их фармацевтические композиции
PT1150703E (pt) Terapia de esclerose multipla com chaperonina 10 e beta-interferao
EA200100152A1 (ru) Замещенные пиперазиноны и их терапевтическое применение
EA199800368A1 (ru) Новые промежуточные продукты и их использование для получения n,n'-мостиковых бисиндолилмалеимидов
EA200000006A1 (ru) Новые производные пентаэритрита, их получение и применение, а также промежуточные соединения для их синтеза
DE69614552T2 (de) MODIFIZIERTE ALPHA-D-GLCP-(1,2)-ALPHA-D-Glcp-(1,3)-ALPHA-D-Glcp-ANALOGE
ATE308523T1 (de) Ester von 3-(3,4-dihalogenophenyl)-2,6- dioxopiperidine-3-propionsäure als zwischenprodukte
IT1279386B1 (it) 1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
ITMI950956A0 (it) Uso degli enantiomeri (s) di derivati 1,4-diidropiridinici per il trattamento dell'insufficienza cardiaca

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU