NO315687B1 - Anvendelse av nebivolol for fremstilling av et anti-aterogent middel - Google Patents
Anvendelse av nebivolol for fremstilling av et anti-aterogent middel Download PDFInfo
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- NO315687B1 NO315687B1 NO19972980A NO972980A NO315687B1 NO 315687 B1 NO315687 B1 NO 315687B1 NO 19972980 A NO19972980 A NO 19972980A NO 972980 A NO972980 A NO 972980A NO 315687 B1 NO315687 B1 NO 315687B1
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- Prior art keywords
- nebivolol
- compound
- vascular
- formula
- acid
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94203775 | 1994-12-28 | ||
| PCT/EP1995/005174 WO1996019987A1 (en) | 1994-12-28 | 1995-12-21 | Use of nebivolol as an anti-atherogenic |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO972980D0 NO972980D0 (no) | 1997-06-26 |
| NO972980L NO972980L (no) | 1997-06-26 |
| NO315687B1 true NO315687B1 (no) | 2003-10-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19972980A NO315687B1 (no) | 1994-12-28 | 1997-06-26 | Anvendelse av nebivolol for fremstilling av et anti-aterogent middel |
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|---|---|
| US (2) | US5874461A (pt) |
| EP (1) | EP0801564B1 (pt) |
| JP (1) | JPH10511655A (pt) |
| KR (1) | KR100264348B1 (pt) |
| CN (1) | CN1167418C (pt) |
| AT (1) | ATE214924T1 (pt) |
| AU (1) | AU700364B2 (pt) |
| CA (1) | CA2207333C (pt) |
| CZ (1) | CZ287513B6 (pt) |
| DE (1) | DE69526120T2 (pt) |
| DK (1) | DK0801564T3 (pt) |
| ES (1) | ES2176354T3 (pt) |
| FI (1) | FI118884B (pt) |
| HU (1) | HU226208B1 (pt) |
| NO (1) | NO315687B1 (pt) |
| NZ (1) | NZ298074A (pt) |
| PT (1) | PT801564E (pt) |
| SI (1) | SI0801564T1 (pt) |
| SK (1) | SK282144B6 (pt) |
| WO (1) | WO1996019987A1 (pt) |
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| SK282144B6 (sk) * | 1994-12-28 | 2001-11-06 | Janssen Pharmaceutica N. V. | Liečivo na terapeutické a profylaktické ošetrenie degeneratívnych chorôb vaskulárneho systému a nervovej sústavy, ktoré súvisia s oxidačným stresom |
| DE19716120A1 (de) * | 1997-04-17 | 1998-10-22 | Europ Lab Molekularbiolog | Verwendung von cholesterinsenkenden Mitteln |
| US6362371B1 (en) | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| US6713651B1 (en) | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
| JP2000207219A (ja) * | 1999-01-18 | 2000-07-28 | Fujitsu Ten Ltd | 車載端末とセンタ―との間の通信システム、及び、通信システムに使用する車載端末 |
| US6683115B2 (en) | 1999-06-02 | 2004-01-27 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6593497B1 (en) | 1999-06-02 | 2003-07-15 | Theravance, Inc. | β2-adrenergic receptor agonists |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| CA2446064A1 (en) | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
| US7491312B2 (en) * | 2002-10-30 | 2009-02-17 | Edison Pharmaceuticals, Inc. | Identifying therapeutic compounds based on their physical-chemical properties |
| ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
| CA2583084C (en) | 2003-09-19 | 2010-12-07 | Galileo Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
| US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| CN101862322A (zh) | 2004-07-30 | 2010-10-20 | 托伦特药物有限公司 | 奈必洛尔及其药学可接受盐、制备方法以及奈必洛尔的药物组合物 |
| EP1848424B1 (en) * | 2005-01-31 | 2017-04-05 | Mylan Laboratories, Inc | Pharmaceutical composition comprising hydroxylated nebivolol |
| DK2564843T3 (en) | 2005-06-01 | 2019-03-11 | Bioelectron Tech Corp | Redox-active therapeutics for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers |
| EA019675B1 (ru) | 2006-02-22 | 2014-05-30 | Эдисон Фармасьютикалз, Инк. | Редокс-активные терапевтические средства для лечения митохондриальных заболеваний и модуляции биомаркера коэнзима q |
| EP2220030B1 (en) | 2007-11-06 | 2016-01-13 | Edison Pharmaceuticals, Inc. | 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| US20090181975A1 (en) * | 2008-01-15 | 2009-07-16 | Forest Laboratories Holdings Limited | Nebivolol in the treatment of sexual dysfunction |
| EP2262508B1 (en) | 2008-03-05 | 2018-10-03 | BioElectron Technology Corporation | SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| CA2736250C (en) | 2008-09-10 | 2016-12-20 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| EP2362726B1 (en) | 2008-10-14 | 2018-08-08 | Bioelectron Technology Corporation | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| SG172275A1 (en) * | 2008-12-19 | 2011-07-28 | Schering Corp | Feed supplement for mammalian cell culture and methods of use |
| EP2424495B1 (en) | 2009-04-28 | 2018-01-17 | Bioelectron Technology Corporation | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
| WO2011150859A1 (en) * | 2010-06-04 | 2011-12-08 | Comprehensive Drug Enterprises Ltd | Oral meclizine aqueous formulations with taste flavoring agent |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| DE102014107132A1 (de) | 2014-05-20 | 2015-11-26 | Corden Pharma International Gmbh | Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind |
| CN107106550A (zh) * | 2014-10-24 | 2017-08-29 | 朗齐生物医学股份有限公司 | 阿折地平在制备治疗癌症的医药组合物中的用途 |
| AU2015364640B2 (en) | 2014-12-16 | 2020-08-13 | Ptc Therapeutics, Inc. | Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
| JP6905527B2 (ja) | 2015-12-17 | 2021-07-21 | ピーティーシー セラピューティクス， インコーポレイテッド | 酸化ストレス障害を処置するためのフルオロアルキル、フルオロアルコキシ、フェノキシ、ヘテロアリールオキシ、アルコキシ、およびアミノ１，４−ベンゾキノン誘導体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337432C (en) * | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
| TW355683B (en) * | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
| SK282144B6 (sk) * | 1994-12-28 | 2001-11-06 | Janssen Pharmaceutica N. V. | Liečivo na terapeutické a profylaktické ošetrenie degeneratívnych chorôb vaskulárneho systému a nervovej sústavy, ktoré súvisia s oxidačným stresom |
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1995
- 1995-12-21 SK SK856-97A patent/SK282144B6/sk not_active IP Right Cessation
- 1995-12-21 US US08/860,238 patent/US5874461A/en not_active Expired - Lifetime
- 1995-12-21 CN CNB951971492A patent/CN1167418C/zh not_active Expired - Lifetime
- 1995-12-21 NZ NZ298074A patent/NZ298074A/xx not_active IP Right Cessation
- 1995-12-21 ES ES95942209T patent/ES2176354T3/es not_active Expired - Lifetime
- 1995-12-21 DE DE69526120T patent/DE69526120T2/de not_active Expired - Lifetime
- 1995-12-21 JP JP8520223A patent/JPH10511655A/ja active Pending
- 1995-12-21 PT PT95942209T patent/PT801564E/pt unknown
- 1995-12-21 AU AU43477/96A patent/AU700364B2/en not_active Expired
- 1995-12-21 EP EP95942209A patent/EP0801564B1/en not_active Expired - Lifetime
- 1995-12-21 CA CA002207333A patent/CA2207333C/en not_active Expired - Fee Related
- 1995-12-21 DK DK95942209T patent/DK0801564T3/da active
- 1995-12-21 AT AT95942209T patent/ATE214924T1/de active
- 1995-12-21 HU HU9800675A patent/HU226208B1/hu unknown
- 1995-12-21 KR KR1019970703648A patent/KR100264348B1/ko not_active IP Right Cessation
- 1995-12-21 CZ CZ19971919A patent/CZ287513B6/cs not_active IP Right Cessation
- 1995-12-21 SI SI9530591T patent/SI0801564T1/xx unknown
- 1995-12-21 WO PCT/EP1995/005174 patent/WO1996019987A1/en active IP Right Grant
-
1997
- 1997-06-26 NO NO19972980A patent/NO315687B1/no not_active IP Right Cessation
- 1997-06-27 FI FI972793A patent/FI118884B/fi not_active IP Right Cessation
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1998
- 1998-12-21 US US09/217,728 patent/US6075046A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CZ191997A3 (cs) | 1999-01-13 |
| AU700364B2 (en) | 1999-01-07 |
| CZ287513B6 (en) | 2000-12-13 |
| DK0801564T3 (da) | 2002-07-15 |
| SK282144B6 (sk) | 2001-11-06 |
| AU4347796A (en) | 1996-07-19 |
| SI0801564T1 (en) | 2002-08-31 |
| FI972793A0 (fi) | 1997-06-27 |
| PT801564E (pt) | 2002-09-30 |
| CA2207333A1 (en) | 1996-07-04 |
| EP0801564B1 (en) | 2002-03-27 |
| ES2176354T3 (es) | 2002-12-01 |
| HUT77927A (hu) | 1998-11-30 |
| KR100264348B1 (ko) | 2000-08-16 |
| DE69526120T2 (de) | 2002-11-28 |
| US5874461A (en) | 1999-02-23 |
| CN1167418C (zh) | 2004-09-22 |
| NZ298074A (en) | 2001-01-26 |
| MX9704669A (es) | 1997-09-30 |
| US6075046A (en) | 2000-06-13 |
| DE69526120D1 (de) | 2002-05-02 |
| CN1171739A (zh) | 1998-01-28 |
| WO1996019987A1 (en) | 1996-07-04 |
| ATE214924T1 (de) | 2002-04-15 |
| SK85697A3 (en) | 2000-04-10 |
| EP0801564A1 (en) | 1997-10-22 |
| FI972793A (fi) | 1997-06-27 |
| HU226208B1 (en) | 2008-06-30 |
| NO972980D0 (no) | 1997-06-26 |
| NO972980L (no) | 1997-06-26 |
| CA2207333C (en) | 2006-10-17 |
| FI118884B (fi) | 2008-04-30 |
| JPH10511655A (ja) | 1998-11-10 |
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| MK1K | Patent expired |