ES2196456T3 - Compuestos ciclicos de cinco eslabones en el anillo condensado que llevan un grupo sulfonamida, su uso como medicamentos y composiciones farmaceuticas que los contienen. - Google Patents

Compuestos ciclicos de cinco eslabones en el anillo condensado que llevan un grupo sulfonamida, su uso como medicamentos y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2196456T3
ES2196456T3 ES98120913T ES98120913T ES2196456T3 ES 2196456 T3 ES2196456 T3 ES 2196456T3 ES 98120913 T ES98120913 T ES 98120913T ES 98120913 T ES98120913 T ES 98120913T ES 2196456 T3 ES2196456 T3 ES 2196456T3
Authority
ES
Spain
Prior art keywords
link
carry
compositions containing
condensed ring
sulfonamide group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98120913T
Other languages
English (en)
Inventor
Joachim Dr Brendel
Uwe Dr Gerlach
Hans Jochen Dr Lang
Klaus Dr Weidmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Application granted granted Critical
Publication of ES2196456T3 publication Critical patent/ES2196456T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA I CON LOS SIGNIFICADOS DE LOS SUSTITUYENTES INDICADOS EN LAS REIVINDICACIONES, SON SUSTANCIAS MUY EFECTIVAS PARA LA PREPARACION DE MEDICAMENTOS PARA LA PREVENCION Y PARA LA TERAPIA DE ENFERMEDADES CIRCULATORIAS CARDIACAS, EN PARTICULAR ARRITMIAS, PARA EL TRATAMIENTO DE ULCERA DE LA ZONA DEL ESTOMAGO E INTESTINO O PARA EL TRATAMIENTO DE ENFERMEDADES CON COLITIS.
ES98120913T 1997-11-10 1998-11-04 Compuestos ciclicos de cinco eslabones en el anillo condensado que llevan un grupo sulfonamida, su uso como medicamentos y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2196456T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19749453A DE19749453A1 (de) 1997-11-10 1997-11-10 Sulfonamid-substituierte anellierte 5-Ring-Verbindungen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen

Publications (1)

Publication Number Publication Date
ES2196456T3 true ES2196456T3 (es) 2003-12-16

Family

ID=7848065

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98120913T Expired - Lifetime ES2196456T3 (es) 1997-11-10 1998-11-04 Compuestos ciclicos de cinco eslabones en el anillo condensado que llevan un grupo sulfonamida, su uso como medicamentos y composiciones farmaceuticas que los contienen.

Country Status (29)

Country Link
US (1) US6015822A (es)
EP (1) EP0915087B1 (es)
JP (1) JP4331809B2 (es)
KR (1) KR19990045147A (es)
CN (1) CN1219533A (es)
AR (1) AR016006A1 (es)
AT (1) ATE236120T1 (es)
AU (1) AU742199B2 (es)
BR (1) BR9804995A (es)
CA (1) CA2253211C (es)
CZ (1) CZ363798A3 (es)
DE (2) DE19749453A1 (es)
DK (1) DK0915087T3 (es)
ES (1) ES2196456T3 (es)
HR (1) HRP980585B1 (es)
HU (1) HUP9802590A3 (es)
ID (1) ID21282A (es)
IL (1) IL126955A (es)
MY (1) MY115619A (es)
NO (1) NO312546B1 (es)
NZ (1) NZ332633A (es)
PL (1) PL329596A1 (es)
PT (1) PT915087E (es)
RU (1) RU2223951C2 (es)
SI (1) SI0915087T1 (es)
SK (1) SK283866B6 (es)
TR (1) TR199802270A2 (es)
TW (1) TW427970B (es)
ZA (1) ZA9810202B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9911914B1 (pt) * 1998-07-08 2010-10-19 n-arilamidas do ácido sulfonilaminocarboxìlico substituìdas por enxofre, processo para sua preparação, bem como preparações farmacêuticas que compreendem as mesmas.
DE19929076A1 (de) * 1999-06-25 2000-12-28 Aventis Pharma Gmbh Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US6458794B2 (en) 1999-12-21 2002-10-01 Icagen, Inc. Potassium channel inhibitors
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors
JP4197649B2 (ja) * 2001-12-12 2008-12-17 エフ．ホフマン−ラ ロシュ アーゲー アデノシン受容体モジュレーターとしてのベンゾチオフェン
US7119112B2 (en) * 2002-02-28 2006-10-10 Icagen, Inc. Sulfonamides as potassium channel blockers
US7932284B2 (en) * 2006-01-24 2011-04-26 Eli Lilly And Company Indole sulfonamide modulators of progesterone receptors
JP2009026126A (ja) * 2007-07-20 2009-02-05 Nec Electronics Corp 半導体装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8602606A1 (es) * 1983-03-04 1985-12-01 Otsuka Pharma Co Ltd Derivados de indano y sus sales
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3737195A1 (de) * 1987-11-03 1989-05-18 Bayer Ag Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
FR2639349B1 (fr) * 1988-11-23 1991-02-22 Sanofi Sa Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
US5877218A (en) * 1994-01-10 1999-03-02 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives

Also Published As

Publication number Publication date
CN1219533A (zh) 1999-06-16
AR016006A1 (es) 2001-05-30
TR199802270A2 (xx) 1999-05-21
HU9802590D0 (en) 1999-01-28
HRP980585A2 (en) 1999-06-30
RU2223951C2 (ru) 2004-02-20
HUP9802590A3 (en) 2001-08-28
SK283866B6 (sk) 2004-03-02
PT915087E (pt) 2003-08-29
US6015822A (en) 2000-01-18
ZA9810202B (en) 1999-05-10
CZ363798A3 (cs) 1999-05-12
CA2253211C (en) 2009-04-14
BR9804995A (pt) 2001-05-22
NO985171L (no) 1999-05-11
IL126955A (en) 2002-11-10
CA2253211A1 (en) 1999-05-10
IL126955A0 (en) 1999-09-22
NO312546B1 (no) 2002-05-27
EP0915087A3 (de) 1999-07-21
EP0915087A2 (de) 1999-05-12
TW427970B (en) 2001-04-01
SK154598A3 (en) 1999-06-11
DE19749453A1 (de) 1999-05-12
JPH11236368A (ja) 1999-08-31
JP4331809B2 (ja) 2009-09-16
SI0915087T1 (en) 2003-10-31
ID21282A (id) 1999-05-12
NO985171D0 (no) 1998-11-05
HRP980585B1 (en) 2003-02-28
DE59807718D1 (de) 2003-05-08
EP0915087B1 (de) 2003-04-02
DK0915087T3 (da) 2003-07-21
AU9139898A (en) 1999-05-27
HUP9802590A2 (hu) 2000-04-28
NZ332633A (en) 2000-05-26
MY115619A (en) 2003-07-31
ATE236120T1 (de) 2003-04-15
KR19990045147A (ko) 1999-06-25
AU742199B2 (en) 2001-12-20
PL329596A1 (en) 1999-05-24

Similar Documents

Publication Publication Date Title
ES2179351T3 (es) Amidas acidas de piridil alqueno y piridil alquino como citoestaticos e inmunosupresores.
ES2152222T3 (es) Sulfonamidas, su preparacion y su uso como medicamento e intermedio.
AR025959A1 (es) DERIVADOS DE TER.-BUTIL-(7-METIL-IMIDAZO[1,2,a]PIRIDIN-3-IL)-AMINA, PROCEDIMIENTO PARA SU PREPARACION, MEDICAMENTOS QUE LOS CONTIENEN, SU USO PARA LAPREPARACION DE UN MEDICAMENTO PARA LA INHIBICION DE NO-SINTASA Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN
ES2188929T3 (es) Analogos 2-peptidicos de tipo glucagon.
ES2191192T3 (es) Tienopirimidinas.
ES2093694T3 (es) Nuevos derivados de dihidro-isoquinoleina.
AR031430A1 (es) Compuestos de bisarilo orto, meta-sustituidos, procedimientos para su preparacion, su utilizacion como medicamento como tambien los preparados farmaceuticos que los contienen
PA8442001A1 (es) Derivados de pirimidina biciclica condensada
UY26130A1 (es) Compuestos para tratar la obesidad
ES2088388T3 (es) Composiciones de macrolido para el tratamiento de trastornos de movilidad gastrointestinal.
BR9708114A (pt) Análogos xantona para o tratamento de doenças infecciosas.
ES2196456T3 (es) Compuestos ciclicos de cinco eslabones en el anillo condensado que llevan un grupo sulfonamida, su uso como medicamentos y composiciones farmaceuticas que los contienen.
ES2053454T3 (es) Composiciones farmaceuticas que contienen peptidos del grupo de la colecistoquinina-ceruleina para la terapia de estados de shock y de insuficiencias respiratorias y cardiocirculatorias.
ES2154002T3 (es) 2-naftoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.
TR200100637T2 (tr) Yeni doğal ürün türevleri
ES2175582T3 (es) Cromanos sustituidos con sulfonamida, procedimiento para su preparacion, su utilizacion como medicamento, asi como preparados farmaceuticos que los contienen.
ES2167721T3 (es) Utilizacion de 1-hidroxi-2-piridonas para el tratamiento de la dermatitis seborreica.
ATE5256T1 (de) Phenylpiperazinderivate von 1,3,4oxadiazolylphenolen, ihre herstellung und diese enthaltende therapeutische mittel.
ES2110057T3 (es) Composicion medicinal que contiene tcf-ii.
ES2062120T3 (es) Nuevas n-(aril substituido)-n'-(alcoxi substituido)-ureas y tioureas como agentes anticolesterolemicos y antiateroscleroticos.
ES2158383T3 (es) Guanididas de acidos tiofenil-alquenil-carboxilicos sustituidos, procedimiento para su preparacion, su utilizacion como medicamento o agente diagnostico, asi como medicamento que las contiene.
ES2144857T3 (es) Utilizacion de derivados benzonaftalenicos para la fabricacion de medicamentos destinados para el tratamiento de las enfermedades del sistema nervioso.
ES2170402T3 (es) Derivados de benzo(g)quinolina.
ES2055440T3 (es) Derivados del acido quinurenico, su preparacion y composiciones farmaceuticas que los contienen.
ES2146348T3 (es) Cromanilsulfonil(tio)ureas sustituidas, procedimiento para su preparacion y su utilizacion en preparados farmaceuticos, asi como preparados farmaceuticos que las contienen.