ES2093694T3 - Nuevos derivados de dihidro-isoquinoleina. - Google Patents
Nuevos derivados de dihidro-isoquinoleina.Info
- Publication number
- ES2093694T3 ES2093694T3 ES91810954T ES91810954T ES2093694T3 ES 2093694 T3 ES2093694 T3 ES 2093694T3 ES 91810954 T ES91810954 T ES 91810954T ES 91810954 T ES91810954 T ES 91810954T ES 2093694 T3 ES2093694 T3 ES 2093694T3
- Authority
- ES
- Spain
- Prior art keywords
- isoquinolein
- dihydro
- new derivatives
- alcoxi
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Abstract
6,7-DI(C SUB 1-4ALCOXI)-1-[3,5-DI(C SUB 1-4 ALCOXI)FENIL]-3,4-DIHIDRO-3 -HIDROXI-METIL-ISOQUINOLINAS, SIENDO NOVEDOSOS SUS ESTERES HIDROLIZABLES Y ACEPTABLES FISIOLOGICAMENTE Y SALES ACIDAS DE ADICION DE LO MISMO. LOS MENCIONADOS COMPUESTOS, ESTERES Y SALES ACIDAS DE ADICION FARMACEUTICAMENTE ACEPTABLES DE LO MISMO SON UTILES COMO FARMACOS, E. J. EN EL TRATAMIENTO DEL ASMA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909027055A GB9027055D0 (en) | 1990-12-13 | 1990-12-13 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2093694T3 true ES2093694T3 (es) | 1997-01-01 |
Family
ID=10686945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91810954T Expired - Lifetime ES2093694T3 (es) | 1990-12-13 | 1991-12-09 | Nuevos derivados de dihidro-isoquinoleina. |
Country Status (25)
Country | Link |
---|---|
US (1) | US5177085A (es) |
EP (1) | EP0490823B1 (es) |
JP (1) | JPH0764820B2 (es) |
KR (1) | KR920012040A (es) |
AT (1) | ATE145201T1 (es) |
AU (1) | AU643575B2 (es) |
CA (1) | CA2057524A1 (es) |
CZ (1) | CZ281669B6 (es) |
DE (1) | DE69123124T2 (es) |
DK (1) | DK0490823T3 (es) |
ES (1) | ES2093694T3 (es) |
FI (1) | FI915844A (es) |
GB (1) | GB9027055D0 (es) |
GR (1) | GR3022034T3 (es) |
HU (1) | HUT61729A (es) |
IE (1) | IE914325A1 (es) |
IL (1) | IL100328A (es) |
MX (1) | MX9102502A (es) |
MY (1) | MY129941A (es) |
NZ (1) | NZ240936A (es) |
PL (1) | PL168329B1 (es) |
PT (1) | PT99775B (es) |
RU (1) | RU2060992C1 (es) |
TW (1) | TW201736B (es) |
ZA (1) | ZA919858B (es) |
Families Citing this family (75)
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---|---|---|---|---|
GB9212673D0 (en) * | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
GB9226830D0 (en) * | 1992-12-23 | 1993-02-17 | Celltech Ltd | Chemical compounds |
US5622977A (en) * | 1992-12-23 | 1997-04-22 | Celltech Therapeutics Limited | Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same |
GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
GB9322828D0 (en) * | 1993-11-05 | 1993-12-22 | Sandoz Ltd | Organic compounds |
GB9326173D0 (en) * | 1993-12-22 | 1994-02-23 | Celltech Ltd | Chemical compounds and process |
JP3806144B2 (ja) * | 1993-12-22 | 2006-08-09 | セルテック セラピューティックス リミテッド | 三置換フェニル誘導体、その調製方法とホスホジエステラーゼ(iv型)阻害剤としてのその使用 |
US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
GB9412573D0 (en) * | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
ATE211726T1 (de) * | 1994-08-22 | 2002-01-15 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
US5948820A (en) | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
AU4527996A (en) * | 1994-12-13 | 1996-07-03 | Euro-Celtique S.A. | Trisubstituted thioxanthines |
US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
US6268373B1 (en) * | 1995-06-07 | 2001-07-31 | Euro-Celtique S.A. | Trisubstituted thioxanthines |
GB9523267D0 (en) * | 1995-11-14 | 1996-01-17 | Sandoz Ltd | Organic compounds |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
GB9526246D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
GB9526245D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
GB9526243D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
WO1997034473A1 (en) * | 1996-03-21 | 1997-09-25 | The Trustees Of Columbia University In The City Of New York | Craf1 (traf-3) isoforms and uses thereof |
US6075016A (en) * | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
AU4674797A (en) * | 1996-10-22 | 1998-05-15 | Ortho Pharmaceutical Corporation | Phenylalaninol derivatives for the treatment of central nervous system disorders |
GB9622363D0 (en) | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
GB9625184D0 (en) * | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
ID19155A (id) * | 1996-12-13 | 1998-06-18 | Tanabe Seiyaku Co | Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya |
AU5330698A (en) | 1996-12-23 | 1998-07-17 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors |
WO1998038168A1 (en) * | 1997-02-27 | 1998-09-03 | Tanabe Seiyaku Co., Ltd. | Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors |
GB9705361D0 (en) * | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
DE69822162T2 (de) * | 1997-07-25 | 2005-01-27 | Altana Pharma Ag | Neue tetrazolderivate |
JP2001518468A (ja) * | 1997-09-30 | 2001-10-16 | モレキュラー デザインズ インターナショナル,インコーポレイテッド | β3アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法 |
IT1296985B1 (it) | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 |
IT1302677B1 (it) | 1998-10-15 | 2000-09-29 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 |
GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
ATE447952T1 (de) | 1999-08-21 | 2009-11-15 | Nycomed Gmbh | Synergistische kombination von pumafentrine und salmeterol |
GB9924862D0 (en) * | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
EP1270577B1 (en) * | 2000-03-23 | 2006-12-06 | Takeda Pharmaceutical Company Limited | Furoisoquinoline derivatives, process for producing the same and use thereof |
US6818651B2 (en) | 2000-11-14 | 2004-11-16 | Altana Pharma Ag | (Dihydro) isoquinoline derivatives as phosphodiesterase inhibitors |
WO2002040449A1 (en) * | 2000-11-14 | 2002-05-23 | Altana Pharma Ag | Dihydroisoquinolines as novel phosphodiesterase inhibitors |
US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
MEP13408A (en) * | 2001-05-29 | 2010-06-10 | Bayer Schering Pharma Ag | Cdk inhibiting pyrimidines, production thereof and their use as medicaments |
CA2473461C (en) * | 2002-01-11 | 2011-11-01 | Sankyo Company, Limited | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
US7745180B2 (en) * | 2002-04-24 | 2010-06-29 | Hitachi Chemical Co., Ltd. | Device and method for high-throughput quantification of mRNA from whole blood |
CA2495597A1 (en) * | 2002-08-17 | 2004-03-04 | Altana Pharma Ag | Novel phenanthridines |
CA2495603A1 (en) * | 2002-08-17 | 2004-03-04 | Altana Pharma Ag | Benzonaphthyridines with pde 3/4 inhibiting activity |
EP1536798B1 (en) | 2002-08-29 | 2007-02-07 | ALTANA Pharma AG | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
JP4587294B2 (ja) * | 2002-08-29 | 2010-11-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pde4インヒビターとしての2−ヒドロキシ−6−フェニルフェナントリジン |
US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
MXPA05010373A (es) | 2003-04-01 | 2005-12-05 | Applied Research Systems | Inhibidores de fosfodiesterasas en infertilidad. |
CA2556086C (en) | 2004-02-18 | 2014-04-01 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
US7910617B2 (en) | 2004-02-24 | 2011-03-22 | Sankyo Company, Limited | Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound |
BRPI0508321B1 (pt) | 2004-03-03 | 2018-02-06 | Takeda Gmbh | Hidróxi-6-heteroarilfenantridinas, seu uso e composições farmacêuticas que as compreende |
ATE450524T1 (de) | 2005-03-02 | 2009-12-15 | Nycomed Gmbh | (2r,4ar,10br)-6-(2,6-dimethoxypyridin-3-yl)-9- ethoxy-8-methoxy-1,2,3,4,4a,10b- hexahydrophenanthridin-2-ol hydrochloridsalz |
EP2998314B1 (en) | 2007-06-04 | 2020-01-22 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US9580471B2 (en) | 2011-03-01 | 2017-02-28 | Synergy Pharmaceuticals, Inc. | Process of preparing guanylate cyclase C agonists |
EP3718557A3 (en) | 2013-02-25 | 2020-10-21 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
WO2015021358A2 (en) | 2013-08-09 | 2015-02-12 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
AU2014307803A1 (en) | 2013-08-16 | 2016-03-10 | Universiteit Maastricht | Treatment of cognitive impairment with PDE4 inhibitor |
CN114340631A (zh) | 2019-05-21 | 2022-04-12 | 阿德利克斯股份有限公司 | 用于降低患者的血清磷酸盐的组合 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1400425A (en) * | 1971-09-22 | 1975-07-16 | Rolland Sa A | Substituted 3-hydroxymethyl-isoquinolines and derivatives |
PH25651A (en) * | 1986-05-21 | 1991-08-21 | Duphar Int Res | New di, tetrahydroisoquinoline derivatives |
HU196758B (en) * | 1986-05-21 | 1989-01-30 | Gyogyszerkutato Intezet | Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them |
GB8800397D0 (en) * | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds |
-
1990
- 1990-12-13 GB GB909027055A patent/GB9027055D0/en active Pending
-
1991
- 1991-12-02 HU HU913760A patent/HUT61729A/hu unknown
- 1991-12-09 AT AT91810954T patent/ATE145201T1/de not_active IP Right Cessation
- 1991-12-09 EP EP91810954A patent/EP0490823B1/en not_active Expired - Lifetime
- 1991-12-09 ES ES91810954T patent/ES2093694T3/es not_active Expired - Lifetime
- 1991-12-09 DK DK91810954.7T patent/DK0490823T3/da active
- 1991-12-09 DE DE69123124T patent/DE69123124T2/de not_active Expired - Fee Related
- 1991-12-10 MY MYPI91002283A patent/MY129941A/en unknown
- 1991-12-11 CZ CS913757A patent/CZ281669B6/cs unknown
- 1991-12-11 FI FI915844A patent/FI915844A/fi not_active Application Discontinuation
- 1991-12-11 NZ NZ240936A patent/NZ240936A/xx unknown
- 1991-12-11 MX MX9102502A patent/MX9102502A/es unknown
- 1991-12-11 IL IL10032891A patent/IL100328A/en not_active IP Right Cessation
- 1991-12-11 AU AU88985/91A patent/AU643575B2/en not_active Ceased
- 1991-12-12 PT PT99775A patent/PT99775B/pt not_active IP Right Cessation
- 1991-12-12 IE IE432591A patent/IE914325A1/en unknown
- 1991-12-12 JP JP3328665A patent/JPH0764820B2/ja not_active Expired - Lifetime
- 1991-12-12 RU SU915010401A patent/RU2060992C1/ru active
- 1991-12-12 KR KR1019910022728A patent/KR920012040A/ko not_active Application Discontinuation
- 1991-12-12 PL PL91292738A patent/PL168329B1/pl unknown
- 1991-12-12 US US07/805,662 patent/US5177085A/en not_active Expired - Fee Related
- 1991-12-12 CA CA002057524A patent/CA2057524A1/en not_active Abandoned
- 1991-12-13 ZA ZA919858A patent/ZA919858B/xx unknown
- 1991-12-13 TW TW080109769A patent/TW201736B/zh active
-
1996
- 1996-12-13 GR GR960403459T patent/GR3022034T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL292738A1 (en) | 1992-12-14 |
US5177085A (en) | 1993-01-05 |
MX9102502A (es) | 1992-06-01 |
ZA919858B (en) | 1993-06-14 |
HUT61729A (en) | 1993-03-01 |
GB9027055D0 (en) | 1991-02-06 |
JPH0764820B2 (ja) | 1995-07-12 |
AU8898591A (en) | 1992-06-18 |
DK0490823T3 (es) | 1997-02-17 |
AU643575B2 (en) | 1993-11-18 |
ATE145201T1 (de) | 1996-11-15 |
HU913760D0 (en) | 1992-02-28 |
TW201736B (es) | 1993-03-11 |
JPH04275276A (ja) | 1992-09-30 |
IL100328A (en) | 1995-12-08 |
GR3022034T3 (en) | 1997-03-31 |
CA2057524A1 (en) | 1992-06-14 |
EP0490823B1 (en) | 1996-11-13 |
PT99775B (pt) | 1999-05-31 |
CZ281669B6 (cs) | 1996-12-11 |
DE69123124T2 (de) | 1997-05-15 |
MY129941A (en) | 2007-05-31 |
KR920012040A (ko) | 1992-07-25 |
FI915844A (fi) | 1992-06-14 |
NZ240936A (en) | 1993-09-27 |
RU2060992C1 (ru) | 1996-05-27 |
CS375791A3 (en) | 1992-06-17 |
EP0490823A1 (en) | 1992-06-17 |
PL168329B1 (pl) | 1996-02-29 |
FI915844A0 (fi) | 1991-12-11 |
IL100328A0 (en) | 1992-09-06 |
PT99775A (pt) | 1992-11-30 |
IE914325A1 (en) | 1992-06-17 |
DE69123124D1 (de) | 1996-12-19 |
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