ES2135811T3 - Indenoil-guanidinas sustituidas antiarritmicas y cardioprotectoras. - Google Patents
Indenoil-guanidinas sustituidas antiarritmicas y cardioprotectoras.Info
- Publication number
- ES2135811T3 ES2135811T3 ES96105873T ES96105873T ES2135811T3 ES 2135811 T3 ES2135811 T3 ES 2135811T3 ES 96105873 T ES96105873 T ES 96105873T ES 96105873 T ES96105873 T ES 96105873T ES 2135811 T3 ES2135811 T3 ES 2135811T3
- Authority
- ES
- Spain
- Prior art keywords
- indenoil
- guanidinas
- cardioprotector
- antiarrhythmic
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003288 anthiarrhythmic effect Effects 0.000 title 1
- 239000003416 antiarrhythmic agent Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Optical Record Carriers And Manufacture Thereof (AREA)
Abstract
SE DESCRIBEN INDENOILGUANIDINAS DE FORMULA I, EL PROCEDIMIENTO PARA SU PREPARACION, SU USO COMO MEDICAMENTOS, MEDICAMENTOS QUE LAS CONTIENEN, SU USO COMO AGENTES DE DIAGNOSTICO Y MEDICAMENTOS QUE CONTIENEN LOS MISMOS. COMPUESTOS I SON UTILES PARA EL TRATAMIENTO DE ARRITMIAS CARDIACAS. ADEMAS SON UTILES COMO AGENTES CARDIOPROTECTOTES EN MAMIFEROS, QUE COMPRENDE LA ADMINISTRACION DEL COMPUESTO DE FORMULA I CON LAS PROPIEDADES ARRIBA DESCRITAS EN COMBINACION CON UN TRANSPORTADOR FARMACEUTICAMENTE ACEPTADO PARA DICHO MAMIFERO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95105724 | 1995-04-18 | ||
US08/633,223 US5733934A (en) | 1995-04-18 | 1996-04-16 | Antiarrythmic and cardioprotective substituted indenoylguanidines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2135811T3 true ES2135811T3 (es) | 1999-11-01 |
Family
ID=26138562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96105873T Expired - Lifetime ES2135811T3 (es) | 1995-04-18 | 1996-04-15 | Indenoil-guanidinas sustituidas antiarritmicas y cardioprotectoras. |
Country Status (23)
Country | Link |
---|---|
US (1) | US5733934A (es) |
EP (1) | EP0738712B1 (es) |
JP (1) | JPH08291131A (es) |
CN (1) | CN1061648C (es) |
AT (1) | ATE183498T1 (es) |
AU (1) | AU706055B2 (es) |
BR (1) | BR9601989A (es) |
CA (1) | CA2174406A1 (es) |
CZ (1) | CZ291538B6 (es) |
DE (1) | DE69603771T2 (es) |
DK (1) | DK0738712T3 (es) |
ES (1) | ES2135811T3 (es) |
GR (1) | GR3031540T3 (es) |
HU (1) | HUP9600998A3 (es) |
IL (1) | IL117927A (es) |
NO (1) | NO305655B1 (es) |
NZ (1) | NZ286380A (es) |
PL (1) | PL182566B1 (es) |
RU (1) | RU2182902C2 (es) |
SI (1) | SI0738712T1 (es) |
SK (1) | SK282011B6 (es) |
TR (1) | TR199600316A1 (es) |
ZA (1) | ZA963046B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002502414A (ja) * | 1997-06-02 | 2002-01-22 | 藤沢薬品工業株式会社 | 細胞中のNa▲上+▼/H▲上+▼交換の阻害剤としてのグアニジン誘導体 |
US6160134A (en) * | 1997-12-24 | 2000-12-12 | Bristol-Myers Squibb Co. | Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines |
US6011059A (en) * | 1997-12-24 | 2000-01-04 | Bristol-Myers Squibb Company | Acyl guanidine sodium/proton exchange inhibitors and method |
TW462964B (en) * | 1998-05-26 | 2001-11-11 | Sumitomo Pharma | Guanidine derivatives for the treatment and prevention of disorders caused by inhibiting hyperactivity of Na/H exchange transport system and process for producing the same |
DE19859727A1 (de) | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
JP2002542291A (ja) | 1999-04-23 | 2002-12-10 | ブリストル−マイヤーズ スクイブ カンパニー | ジ環式アシルグアニジン・ナトリウム/プロトン交換抑制剤および方法 |
EP2617709B8 (en) * | 2003-06-26 | 2022-12-21 | Biotron Limited | Guanidine derivatives as antiviral agents |
US20070099968A1 (en) * | 2004-06-26 | 2007-05-03 | Biotron Limited | Antiviral compounds and methods |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2734904A (en) * | 1956-02-14 | Xcxnhxc-nh | ||
US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
US4544670A (en) * | 1982-08-24 | 1985-10-01 | William H. Rorer, Inc. | Method of treating coccidiosis with acyl guanidines |
EP0556673B1 (de) * | 1992-02-15 | 1997-09-17 | Hoechst Aktiengesellschaft | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4326005A1 (de) * | 1993-08-03 | 1995-02-09 | Hoechst Ag | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
EP0639573A1 (de) * | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
-
1996
- 1996-04-15 SI SI9630097T patent/SI0738712T1/xx not_active IP Right Cessation
- 1996-04-15 ES ES96105873T patent/ES2135811T3/es not_active Expired - Lifetime
- 1996-04-15 DK DK96105873T patent/DK0738712T3/da active
- 1996-04-15 DE DE69603771T patent/DE69603771T2/de not_active Expired - Fee Related
- 1996-04-15 AT AT96105873T patent/ATE183498T1/de not_active IP Right Cessation
- 1996-04-15 EP EP96105873A patent/EP0738712B1/en not_active Expired - Lifetime
- 1996-04-16 CN CN96104990A patent/CN1061648C/zh not_active Expired - Fee Related
- 1996-04-16 SK SK483-96A patent/SK282011B6/sk unknown
- 1996-04-16 AU AU50676/96A patent/AU706055B2/en not_active Ceased
- 1996-04-16 IL IL11792796A patent/IL117927A/en not_active IP Right Cessation
- 1996-04-16 CZ CZ19961096A patent/CZ291538B6/cs not_active IP Right Cessation
- 1996-04-16 TR TR96/00316A patent/TR199600316A1/xx unknown
- 1996-04-16 US US08/633,223 patent/US5733934A/en not_active Expired - Fee Related
- 1996-04-16 NZ NZ286380A patent/NZ286380A/en unknown
- 1996-04-17 PL PL96313809A patent/PL182566B1/pl unknown
- 1996-04-17 HU HU9600998A patent/HUP9600998A3/hu unknown
- 1996-04-17 JP JP8094952A patent/JPH08291131A/ja active Pending
- 1996-04-17 ZA ZA963046A patent/ZA963046B/xx unknown
- 1996-04-17 RU RU96107258/04A patent/RU2182902C2/ru not_active IP Right Cessation
- 1996-04-17 CA CA002174406A patent/CA2174406A1/en not_active Abandoned
- 1996-04-17 NO NO961521A patent/NO305655B1/no not_active IP Right Cessation
- 1996-04-18 BR BR9601989A patent/BR9601989A/pt active Search and Examination
-
1999
- 1999-10-15 GR GR990402627T patent/GR3031540T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
MX9601424A (es) | 1997-07-31 |
CA2174406A1 (en) | 1996-10-19 |
HUP9600998A2 (en) | 1997-01-28 |
ZA963046B (en) | 1996-10-22 |
HU9600998D0 (en) | 1996-06-28 |
GR3031540T3 (en) | 2000-01-31 |
BR9601989A (pt) | 1998-04-07 |
CZ291538B6 (cs) | 2003-03-12 |
IL117927A (en) | 2001-12-23 |
SK48396A3 (en) | 1996-12-04 |
HUP9600998A3 (en) | 1997-11-28 |
AU5067696A (en) | 1996-10-31 |
DE69603771D1 (de) | 1999-09-23 |
CZ109696A3 (en) | 1996-11-13 |
IL117927A0 (en) | 1996-08-04 |
TR199600316A1 (tr) | 1997-03-21 |
NO961521D0 (no) | 1996-04-17 |
SI0738712T1 (en) | 1999-12-31 |
NZ286380A (en) | 1997-09-22 |
PL182566B1 (pl) | 2002-01-31 |
CN1061648C (zh) | 2001-02-07 |
AU706055B2 (en) | 1999-06-10 |
EP0738712A1 (en) | 1996-10-23 |
CN1140164A (zh) | 1997-01-15 |
DE69603771T2 (de) | 2000-09-07 |
SK282011B6 (sk) | 2001-10-08 |
RU2182902C2 (ru) | 2002-05-27 |
ATE183498T1 (de) | 1999-09-15 |
NO305655B1 (no) | 1999-07-05 |
NO961521L (no) | 1996-10-21 |
US5733934A (en) | 1998-03-31 |
DK0738712T3 (da) | 2000-03-06 |
JPH08291131A (ja) | 1996-11-05 |
EP0738712B1 (en) | 1999-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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