MX9601424A - Indenoilguanidinas sustituidas antiarritmicas y cardioprotectoras. - Google Patents

Indenoilguanidinas sustituidas antiarritmicas y cardioprotectoras.

Info

Publication number
MX9601424A
MX9601424A MX9601424A MX9601424A MX9601424A MX 9601424 A MX9601424 A MX 9601424A MX 9601424 A MX9601424 A MX 9601424A MX 9601424 A MX9601424 A MX 9601424A MX 9601424 A MX9601424 A MX 9601424A
Authority
MX
Mexico
Prior art keywords
indenoylguanidines
arrhythmic
compounds
formula
cardioprotective
Prior art date
Application number
MX9601424A
Other languages
English (en)
Other versions
MXPA96001424A (es
Inventor
Nirogi Venkata Sat Ramakrishna
Tulsidas Sitaram More
Anagha Suhas Kulkarni
Bansi Lal
Venkata Satya Veerabhadra Roa
Anil Vasantrao Ghate
Ravindra Dattatraya Gupte
Wolfgang Scholzs
Hans-Jochen Lang
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MX9601424A publication Critical patent/MX9601424A/es
Publication of MXPA96001424A publication Critical patent/MXPA96001424A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)

Abstract

Se describen indenoilguanididnas de formula I, el procedimiento para su preparacion, su uso como medicamentos, medicamentos que las contienen, su uso como agentes de diagnostico y medicamentos que los contienen. Los compuestos I son utiles para tratar arritmias cardíacas. Además, estos compuestos son utiles como agentes cardioprotectores en mamíferos, que comprende administrar a dicho mamífero el compuesto de formula I con las propiedades anteriores, en combinacion con un excipiente farmacéuticamente aceptado.
MXPA/A/1996/001424A 1995-04-18 1996-04-17 Indenoilguanidinas sustituidas antiarritmicas ycardioprotectoras MXPA96001424A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95105724 1995-04-18
EP95105724.9 1995-04-18
US08/633,223 US5733934A (en) 1995-04-18 1996-04-16 Antiarrythmic and cardioprotective substituted indenoylguanidines

Publications (2)

Publication Number Publication Date
MX9601424A true MX9601424A (es) 1997-07-31
MXPA96001424A MXPA96001424A (es) 1997-12-01

Family

ID=

Also Published As

Publication number Publication date
GR3031540T3 (en) 2000-01-31
IL117927A (en) 2001-12-23
EP0738712B1 (en) 1999-08-18
CN1061648C (zh) 2001-02-07
CZ109696A3 (en) 1996-11-13
RU2182902C2 (ru) 2002-05-27
CN1140164A (zh) 1997-01-15
SI0738712T1 (en) 1999-12-31
DK0738712T3 (da) 2000-03-06
US5733934A (en) 1998-03-31
ES2135811T3 (es) 1999-11-01
SK48396A3 (en) 1996-12-04
EP0738712A1 (en) 1996-10-23
HUP9600998A3 (en) 1997-11-28
SK282011B6 (sk) 2001-10-08
BR9601989A (pt) 1998-04-07
NO305655B1 (no) 1999-07-05
IL117927A0 (en) 1996-08-04
ATE183498T1 (de) 1999-09-15
HU9600998D0 (en) 1996-06-28
HUP9600998A2 (en) 1997-01-28
DE69603771T2 (de) 2000-09-07
NZ286380A (en) 1997-09-22
PL182566B1 (pl) 2002-01-31
AU5067696A (en) 1996-10-31
CZ291538B6 (cs) 2003-03-12
NO961521L (no) 1996-10-21
AU706055B2 (en) 1999-06-10
ZA963046B (en) 1996-10-22
NO961521D0 (no) 1996-04-17
TR199600316A1 (tr) 1997-03-21
DE69603771D1 (de) 1999-09-23
JPH08291131A (ja) 1996-11-05
CA2174406A1 (en) 1996-10-19

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees