HUP9600998A3 - Antiarrhythmic and cardioprotective substituted indenoylguanidines, pharmaceutical compns. contg. them and process for preparing the sald compds. - Google Patents
Antiarrhythmic and cardioprotective substituted indenoylguanidines, pharmaceutical compns. contg. them and process for preparing the sald compds.Info
- Publication number
- HUP9600998A3 HUP9600998A3 HU9600998A HUP9600998A HUP9600998A3 HU P9600998 A3 HUP9600998 A3 HU P9600998A3 HU 9600998 A HU9600998 A HU 9600998A HU P9600998 A HUP9600998 A HU P9600998A HU P9600998 A3 HUP9600998 A3 HU P9600998A3
- Authority
- HU
- Hungary
- Prior art keywords
- indenoylguanidines
- compds
- antiarrhythmic
- sald
- contg
- Prior art date
Links
- 230000003288 anthiarrhythmic effect Effects 0.000 title 1
- 239000003416 antiarrhythmic agent Substances 0.000 title 1
- 230000003293 cardioprotective effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- WBCXYMNAMCHKSU-UHFFFAOYSA-N n-(diaminomethylidene)-1h-indene-1-carboxamide Chemical class C1=CC=C2C(C(=O)NC(=N)N)C=CC2=C1 WBCXYMNAMCHKSU-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Optical Record Carriers And Manufacture Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95105724 | 1995-04-18 | ||
US08/633,223 US5733934A (en) | 1995-04-18 | 1996-04-16 | Antiarrythmic and cardioprotective substituted indenoylguanidines |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9600998D0 HU9600998D0 (en) | 1996-06-28 |
HUP9600998A2 HUP9600998A2 (en) | 1997-01-28 |
HUP9600998A3 true HUP9600998A3 (en) | 1997-11-28 |
Family
ID=26138562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9600998A HUP9600998A3 (en) | 1995-04-18 | 1996-04-17 | Antiarrhythmic and cardioprotective substituted indenoylguanidines, pharmaceutical compns. contg. them and process for preparing the sald compds. |
Country Status (23)
Country | Link |
---|---|
US (1) | US5733934A (hu) |
EP (1) | EP0738712B1 (hu) |
JP (1) | JPH08291131A (hu) |
CN (1) | CN1061648C (hu) |
AT (1) | ATE183498T1 (hu) |
AU (1) | AU706055B2 (hu) |
BR (1) | BR9601989A (hu) |
CA (1) | CA2174406A1 (hu) |
CZ (1) | CZ291538B6 (hu) |
DE (1) | DE69603771T2 (hu) |
DK (1) | DK0738712T3 (hu) |
ES (1) | ES2135811T3 (hu) |
GR (1) | GR3031540T3 (hu) |
HU (1) | HUP9600998A3 (hu) |
IL (1) | IL117927A (hu) |
NO (1) | NO305655B1 (hu) |
NZ (1) | NZ286380A (hu) |
PL (1) | PL182566B1 (hu) |
RU (1) | RU2182902C2 (hu) |
SI (1) | SI0738712T1 (hu) |
SK (1) | SK282011B6 (hu) |
TR (1) | TR199600316A1 (hu) |
ZA (1) | ZA963046B (hu) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998055475A1 (en) * | 1997-06-02 | 1998-12-10 | Fujisawa Pharmaceutical Co., Ltd. | Guanidine deriviatives as inhibitors of na+/h+ exchange in cells |
US6011059A (en) * | 1997-12-24 | 2000-01-04 | Bristol-Myers Squibb Company | Acyl guanidine sodium/proton exchange inhibitors and method |
US6160134A (en) * | 1997-12-24 | 2000-12-12 | Bristol-Myers Squibb Co. | Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines |
TW462964B (en) * | 1998-05-26 | 2001-11-11 | Sumitomo Pharma | Guanidine derivatives for the treatment and prevention of disorders caused by inhibiting hyperactivity of Na/H exchange transport system and process for producing the same |
DE19859727A1 (de) | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
EP1180029A4 (en) | 1999-04-23 | 2002-10-02 | Bristol Myers Squibb Co | BICYCLIC ACYL IHIBITORING SODIUM / PROTON EXCHANGER AND RELATED PROCEDURE. |
BRPI0411900B8 (pt) * | 2003-06-26 | 2021-05-25 | Biotron Ltd | compostos e composições farmacêuticas compreendendo os mesmos |
US20070099968A1 (en) * | 2004-06-26 | 2007-05-03 | Biotron Limited | Antiviral compounds and methods |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2734904A (en) * | 1956-02-14 | Xcxnhxc-nh | ||
US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
US4544670A (en) * | 1982-08-24 | 1985-10-01 | William H. Rorer, Inc. | Method of treating coccidiosis with acyl guanidines |
DE59307360D1 (de) * | 1992-02-15 | 1997-10-23 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4326005A1 (de) * | 1993-08-03 | 1995-02-09 | Hoechst Ag | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
EP0639573A1 (de) * | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
-
1996
- 1996-04-15 DK DK96105873T patent/DK0738712T3/da active
- 1996-04-15 ES ES96105873T patent/ES2135811T3/es not_active Expired - Lifetime
- 1996-04-15 DE DE69603771T patent/DE69603771T2/de not_active Expired - Fee Related
- 1996-04-15 AT AT96105873T patent/ATE183498T1/de not_active IP Right Cessation
- 1996-04-15 EP EP96105873A patent/EP0738712B1/en not_active Expired - Lifetime
- 1996-04-15 SI SI9630097T patent/SI0738712T1/xx not_active IP Right Cessation
- 1996-04-16 AU AU50676/96A patent/AU706055B2/en not_active Ceased
- 1996-04-16 US US08/633,223 patent/US5733934A/en not_active Expired - Fee Related
- 1996-04-16 IL IL11792796A patent/IL117927A/en not_active IP Right Cessation
- 1996-04-16 TR TR96/00316A patent/TR199600316A1/xx unknown
- 1996-04-16 NZ NZ286380A patent/NZ286380A/en unknown
- 1996-04-16 CN CN96104990A patent/CN1061648C/zh not_active Expired - Fee Related
- 1996-04-16 CZ CZ19961096A patent/CZ291538B6/cs not_active IP Right Cessation
- 1996-04-16 SK SK483-96A patent/SK282011B6/sk unknown
- 1996-04-17 PL PL96313809A patent/PL182566B1/pl unknown
- 1996-04-17 RU RU96107258/04A patent/RU2182902C2/ru not_active IP Right Cessation
- 1996-04-17 CA CA002174406A patent/CA2174406A1/en not_active Abandoned
- 1996-04-17 JP JP8094952A patent/JPH08291131A/ja active Pending
- 1996-04-17 HU HU9600998A patent/HUP9600998A3/hu unknown
- 1996-04-17 ZA ZA963046A patent/ZA963046B/xx unknown
- 1996-04-17 NO NO961521A patent/NO305655B1/no not_active IP Right Cessation
- 1996-04-18 BR BR9601989A patent/BR9601989A/pt active Search and Examination
-
1999
- 1999-10-15 GR GR990402627T patent/GR3031540T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NZ286380A (en) | 1997-09-22 |
ATE183498T1 (de) | 1999-09-15 |
SK48396A3 (en) | 1996-12-04 |
NO961521L (no) | 1996-10-21 |
SK282011B6 (sk) | 2001-10-08 |
AU5067696A (en) | 1996-10-31 |
JPH08291131A (ja) | 1996-11-05 |
ES2135811T3 (es) | 1999-11-01 |
NO961521D0 (no) | 1996-04-17 |
IL117927A0 (en) | 1996-08-04 |
SI0738712T1 (en) | 1999-12-31 |
AU706055B2 (en) | 1999-06-10 |
CA2174406A1 (en) | 1996-10-19 |
TR199600316A1 (tr) | 1997-03-21 |
DK0738712T3 (da) | 2000-03-06 |
ZA963046B (en) | 1996-10-22 |
MX9601424A (es) | 1997-07-31 |
PL182566B1 (pl) | 2002-01-31 |
DE69603771T2 (de) | 2000-09-07 |
CZ291538B6 (cs) | 2003-03-12 |
CN1140164A (zh) | 1997-01-15 |
HU9600998D0 (en) | 1996-06-28 |
IL117927A (en) | 2001-12-23 |
NO305655B1 (no) | 1999-07-05 |
DE69603771D1 (de) | 1999-09-23 |
CN1061648C (zh) | 2001-02-07 |
US5733934A (en) | 1998-03-31 |
BR9601989A (pt) | 1998-04-07 |
RU2182902C2 (ru) | 2002-05-27 |
HUP9600998A2 (en) | 1997-01-28 |
CZ109696A3 (en) | 1996-11-13 |
GR3031540T3 (en) | 2000-01-31 |
EP0738712B1 (en) | 1999-08-18 |
EP0738712A1 (en) | 1996-10-23 |
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