ES2167544T3 - Dioxidos de benzotiazina como antagonistas de la endotelina. - Google Patents

Dioxidos de benzotiazina como antagonistas de la endotelina.

Info

Publication number
ES2167544T3
ES2167544T3 ES96903708T ES96903708T ES2167544T3 ES 2167544 T3 ES2167544 T3 ES 2167544T3 ES 96903708 T ES96903708 T ES 96903708T ES 96903708 T ES96903708 T ES 96903708T ES 2167544 T3 ES2167544 T3 ES 2167544T3
Authority
ES
Spain
Prior art keywords
dioxids
benzotiazine
preparation
endotheline antagonists
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96903708T
Other languages
English (en)
Inventor
Kent Alan Berryman
Amy Mae Bunker
Annette Marian Doherty
Jeremy John Edmunds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2167544T3 publication Critical patent/ES2167544T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Dental Preparations (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

NUEVOS DIOXIDOS DE BENZOTIAZINA QUE SON ANTAGONISTAS DE ENDOTELINA, ASI COMO NUEVOS INTERMEDIARIOS UTILIZADOS EN SU PREPARACION, METODOS PARA SU PREPARACION, Y COMPOSICIONES FARMACEUTICAS DE LOS MISMOS, QUE SON UTILES EN EL TRATAMIENTO DE NIVELES ELEVADOS DE ENDOTELINA, HIPERTENSION ESENCIAL MALIGNA RENOVASCULAR Y PULMONAR, INFARTO CEREBRAL, ISQUEMIA CEREBRAL, INSUFICIENCIA CARDIACA CONGESTIVA Y HEMORRAGIA SUBARACNOIDEA.
ES96903708T 1995-02-21 1996-01-26 Dioxidos de benzotiazina como antagonistas de la endotelina. Expired - Lifetime ES2167544T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/393,143 US5599811A (en) 1995-02-21 1995-02-21 Benzothiazine dioxides as endothelin antagonists

Publications (1)

Publication Number Publication Date
ES2167544T3 true ES2167544T3 (es) 2002-05-16

Family

ID=23553452

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96903708T Expired - Lifetime ES2167544T3 (es) 1995-02-21 1996-01-26 Dioxidos de benzotiazina como antagonistas de la endotelina.

Country Status (27)

Country Link
US (1) US5599811A (es)
EP (1) EP0811001B1 (es)
JP (1) JPH11501013A (es)
KR (1) KR19980702358A (es)
CN (1) CN1071327C (es)
AT (1) ATE207911T1 (es)
AU (1) AU720036B2 (es)
BG (1) BG62613B1 (es)
CA (1) CA2211027A1 (es)
CZ (1) CZ294412B6 (es)
DE (1) DE69616515T2 (es)
DK (1) DK0811001T3 (es)
EE (1) EE03564B1 (es)
ES (1) ES2167544T3 (es)
FI (1) FI973380A (es)
GE (1) GEP20001969B (es)
HU (1) HUP9800273A3 (es)
NO (1) NO308897B1 (es)
NZ (1) NZ302116A (es)
PL (1) PL321866A1 (es)
PT (1) PT811001E (es)
RO (1) RO116898B1 (es)
RU (1) RU2164225C2 (es)
SK (1) SK284275B6 (es)
UA (1) UA47424C2 (es)
WO (1) WO1996026195A1 (es)
ZA (1) ZA961342B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US5945448A (en) * 1995-06-02 1999-08-31 Shionogi & Co., Ltd. Brain edema inhibitor
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
TR200101905T2 (tr) 1997-04-28 2002-06-21 Texas Biotechnology Corporation Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler.
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
AU745081B2 (en) 1997-06-27 2002-03-14 Fujisawa Pharmaceutical Co., Ltd. Sulfonamide compounds and medicinal use thereof
ATE270281T1 (de) 1997-09-05 2004-07-15 Warner Lambert Co Benzothiazindioxid-endothelin antagonisten und verfahren zu ihrer herstellung
GB2337048B (en) * 1998-05-05 2000-06-28 Warner Lambert Co 2,1,3-Benzothiadiazole containing endothelin antagonists
CA2409927A1 (en) * 2000-05-31 2001-12-06 Warner-Lambert Company Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
US20020115661A1 (en) * 2000-12-07 2002-08-22 Keller Laurence Harvey Method for treating chronic obstructive pulmonary disease
MX2008013034A (es) * 2006-04-13 2008-10-17 Actelion Pharmaceuticals Ltd Antagonistas del receptor de endotelina para etapas tempranas de fibrosis pulmonar idiopatica.
FR2942797B1 (fr) * 2009-03-03 2011-04-29 Pf Medicament Derives de benzothiazines, leur preparation et leur application a titre de medicaments
EP3509588B1 (en) * 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
CN114671827B (zh) * 2020-12-24 2024-09-20 杭州百新生物医药科技有限公司 邻苯甲酰磺酰亚胺类衍生物及其应用
CN112521384B (zh) * 2021-01-13 2021-11-02 湖北大学 溶剂热一锅法合成苯并噻嗪并环戊二烯衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3237473A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltende arzneimittel
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
JPH0441483A (ja) * 1990-06-07 1992-02-12 Tanabe Seiyaku Co Ltd ベンゾチアジン誘導体及びその製法
ES2164054T3 (es) * 1991-11-05 2002-02-16 Smithkline Beecham Corp Antagonistas de receptores de endotelina.
US5389620A (en) * 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives

Also Published As

Publication number Publication date
WO1996026195A1 (en) 1996-08-29
GEP20001969B (en) 2000-03-05
NO973822L (no) 1997-08-21
NZ302116A (en) 1998-06-26
DE69616515D1 (de) 2001-12-06
RU2164225C2 (ru) 2001-03-20
NO308897B1 (no) 2000-11-13
EE03564B1 (et) 2001-12-17
AU4770396A (en) 1996-09-11
FI973380A0 (fi) 1997-08-18
JPH11501013A (ja) 1999-01-26
HUP9800273A2 (hu) 1999-07-28
CN1180351A (zh) 1998-04-29
SK284275B6 (sk) 2004-12-01
AU720036B2 (en) 2000-05-18
UA47424C2 (uk) 2002-07-15
SK114697A3 (en) 1998-08-05
HUP9800273A3 (en) 1999-09-28
EP0811001A1 (en) 1997-12-10
KR19980702358A (ko) 1998-07-15
CZ260797A3 (cs) 1998-06-17
CN1071327C (zh) 2001-09-19
EE9700147A (et) 1997-12-15
MX9706024A (es) 1997-11-29
CA2211027A1 (en) 1996-08-29
US5599811A (en) 1997-02-04
RO116898B1 (ro) 2001-07-30
NO973822D0 (no) 1997-08-20
ATE207911T1 (de) 2001-11-15
DK0811001T3 (da) 2002-02-18
PL321866A1 (en) 1997-12-22
BG62613B1 (bg) 2000-03-31
PT811001E (pt) 2002-04-29
FI973380A (fi) 1997-08-20
ZA961342B (en) 1996-08-26
BG101867A (en) 1998-10-30
EP0811001B1 (en) 2001-10-31
CZ294412B6 (cs) 2004-12-15
DE69616515T2 (de) 2002-05-16

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