RO116898B1 - Derivaţi de dioxizi de benzotiazină, procedeu pentru prepararea acestora, intermediari, compoziţie farmaceutică şi metodă pentru inhibarea nivelurilor crescute de endotelină - Google Patents

Derivaţi de dioxizi de benzotiazină, procedeu pentru prepararea acestora, intermediari, compoziţie farmaceutică şi metodă pentru inhibarea nivelurilor crescute de endotelină

Info

Publication number
RO116898B1
RO116898B1 RO97-01580A RO9701580A RO116898B1 RO 116898 B1 RO116898 B1 RO 116898B1 RO 9701580 A RO9701580 A RO 9701580A RO 116898 B1 RO116898 B1 RO 116898B1
Authority
RO
Romania
Prior art keywords
endothelin
preparing
same
pharmaceutical compositions
elevated levels
Prior art date
Application number
RO97-01580A
Other languages
English (en)
Inventor
Kent Alan Berryman
Amy Mae Bunker
Annette Marian Doherty
Jeremy John Edmunds
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of RO116898B1 publication Critical patent/RO116898B1/ro

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/021,2-Thiazines; Hydrogenated 1,2-thiazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Dental Preparations (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

Invenţia se referă la dioxizi de benzotiazină, care sunt antagonişti de endotelină, precum şi la procedeele pentru preparare şi la noi intermediari utilizaţi în prepararea acestora, la compoziţiile farmaceutice ale acestora, la metodele pentru tratarea nivelurilor ridicate de endotelină, a hipertensiunii esenţiale renovasculare maligne şi pulmonare, a infarctului cerebral, a ischemiei cerebrale, insuficienţei cardiace congestive şi hemoragiei subarahnoide.
RO97-01580A 1995-02-21 1996-01-26 Derivaţi de dioxizi de benzotiazină, procedeu pentru prepararea acestora, intermediari, compoziţie farmaceutică şi metodă pentru inhibarea nivelurilor crescute de endotelină RO116898B1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/393,143 US5599811A (en) 1995-02-21 1995-02-21 Benzothiazine dioxides as endothelin antagonists
PCT/US1996/001093 WO1996026195A1 (en) 1995-02-21 1996-01-26 Benzothiazine dioxides as endothelin antagonists

Publications (1)

Publication Number Publication Date
RO116898B1 true RO116898B1 (ro) 2001-07-30

Family

ID=23553452

Family Applications (1)

Application Number Title Priority Date Filing Date
RO97-01580A RO116898B1 (ro) 1995-02-21 1996-01-26 Derivaţi de dioxizi de benzotiazină, procedeu pentru prepararea acestora, intermediari, compoziţie farmaceutică şi metodă pentru inhibarea nivelurilor crescute de endotelină

Country Status (27)

Country Link
US (1) US5599811A (ro)
EP (1) EP0811001B1 (ro)
JP (1) JPH11501013A (ro)
KR (1) KR19980702358A (ro)
CN (1) CN1071327C (ro)
AT (1) ATE207911T1 (ro)
AU (1) AU720036B2 (ro)
BG (1) BG62613B1 (ro)
CA (1) CA2211027A1 (ro)
CZ (1) CZ294412B6 (ro)
DE (1) DE69616515T2 (ro)
DK (1) DK0811001T3 (ro)
EE (1) EE03564B1 (ro)
ES (1) ES2167544T3 (ro)
FI (1) FI973380A (ro)
GE (1) GEP20001969B (ro)
HU (1) HUP9800273A3 (ro)
NO (1) NO308897B1 (ro)
NZ (1) NZ302116A (ro)
PL (1) PL321866A1 (ro)
PT (1) PT811001E (ro)
RO (1) RO116898B1 (ro)
RU (1) RU2164225C2 (ro)
SK (1) SK284275B6 (ro)
UA (1) UA47424C2 (ro)
WO (1) WO1996026195A1 (ro)
ZA (1) ZA961342B (ro)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
KR100399797B1 (ko) * 1995-06-02 2004-04-13 시오노기세이야쿠가부시키가이샤 뇌부종억제제
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
JP3455233B2 (ja) 1997-04-28 2003-10-14 テキサス・バイオテクノロジー・コーポレイシヨン エンドテリン介在障害治療用のスルホンアミド類
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
CN1268942A (zh) * 1997-06-27 2000-10-04 藤泽药品工业株式会社 磺酰胺化合物及其药物用途
AU759169B2 (en) 1997-09-05 2003-04-10 Warner-Lambert Company Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
GB2337048B (en) * 1998-05-05 2000-06-28 Warner Lambert Co 2,1,3-Benzothiadiazole containing endothelin antagonists
MXPA02010764A (es) * 2000-05-31 2003-03-10 Warner Lambert Co Combinaciones de un antagonista del receptor endotelina y un compuesto antiepileptico que tiene propiedades para aliviar el dolor o analgesico.
US20020115661A1 (en) * 2000-12-07 2002-08-22 Keller Laurence Harvey Method for treating chronic obstructive pulmonary disease
KR20080111137A (ko) * 2006-04-13 2008-12-22 액테리온 파마슈티칼 리미티드 초기 단계 특발성 폐 섬유증을 위한 엔도텔린 수용체 대항제
FR2942797B1 (fr) * 2009-03-03 2011-04-29 Pf Medicament Derives de benzothiazines, leur preparation et leur application a titre de medicaments
EP3509588B1 (en) * 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
CN114671827B (zh) * 2020-12-24 2024-09-20 杭州百新生物医药科技有限公司 邻苯甲酰磺酰亚胺类衍生物及其应用
CN112521384B (zh) * 2021-01-13 2021-11-02 湖北大学 溶剂热一锅法合成苯并噻嗪并环戊二烯衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3237473A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltende arzneimittel
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
JPH0441483A (ja) * 1990-06-07 1992-02-12 Tanabe Seiyaku Co Ltd ベンゾチアジン誘導体及びその製法
DK0612244T3 (da) * 1991-11-05 2002-01-14 Smithkline Beecham Corp Endothelinreceptorantagonister
US5389620A (en) * 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives

Also Published As

Publication number Publication date
KR19980702358A (ko) 1998-07-15
MX9706024A (es) 1997-11-29
RU2164225C2 (ru) 2001-03-20
DK0811001T3 (da) 2002-02-18
EP0811001B1 (en) 2001-10-31
NO973822L (no) 1997-08-21
CZ260797A3 (cs) 1998-06-17
DE69616515T2 (de) 2002-05-16
WO1996026195A1 (en) 1996-08-29
HUP9800273A2 (hu) 1999-07-28
SK114697A3 (en) 1998-08-05
NO308897B1 (no) 2000-11-13
CN1180351A (zh) 1998-04-29
CA2211027A1 (en) 1996-08-29
AU720036B2 (en) 2000-05-18
EP0811001A1 (en) 1997-12-10
DE69616515D1 (de) 2001-12-06
ATE207911T1 (de) 2001-11-15
JPH11501013A (ja) 1999-01-26
CN1071327C (zh) 2001-09-19
EE9700147A (et) 1997-12-15
HUP9800273A3 (en) 1999-09-28
BG62613B1 (bg) 2000-03-31
AU4770396A (en) 1996-09-11
NZ302116A (en) 1998-06-26
SK284275B6 (sk) 2004-12-01
BG101867A (en) 1998-10-30
PL321866A1 (en) 1997-12-22
FI973380A (fi) 1997-08-20
US5599811A (en) 1997-02-04
GEP20001969B (en) 2000-03-05
ES2167544T3 (es) 2002-05-16
CZ294412B6 (cs) 2004-12-15
NO973822D0 (no) 1997-08-20
PT811001E (pt) 2002-04-29
FI973380A0 (fi) 1997-08-18
EE03564B1 (et) 2001-12-17
UA47424C2 (uk) 2002-07-15
ZA961342B (en) 1996-08-26

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