PT811001E - Dioxidos de benzotiazina como antagonistas de endotelina - Google Patents
Dioxidos de benzotiazina como antagonistas de endotelinaInfo
- Publication number
- PT811001E PT811001E PT96903708T PT96903708T PT811001E PT 811001 E PT811001 E PT 811001E PT 96903708 T PT96903708 T PT 96903708T PT 96903708 T PT96903708 T PT 96903708T PT 811001 E PT811001 E PT 811001E
- Authority
- PT
- Portugal
- Prior art keywords
- dioxides
- benzotiazine
- antagonists
- endothelin
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/393,143 US5599811A (en) | 1995-02-21 | 1995-02-21 | Benzothiazine dioxides as endothelin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT811001E true PT811001E (pt) | 2002-04-29 |
Family
ID=23553452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96903708T PT811001E (pt) | 1995-02-21 | 1996-01-26 | Dioxidos de benzotiazina como antagonistas de endotelina |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5599811A (pt) |
| EP (1) | EP0811001B1 (pt) |
| JP (1) | JPH11501013A (pt) |
| KR (1) | KR19980702358A (pt) |
| CN (1) | CN1071327C (pt) |
| AT (1) | ATE207911T1 (pt) |
| AU (1) | AU720036B2 (pt) |
| BG (1) | BG62613B1 (pt) |
| CA (1) | CA2211027A1 (pt) |
| CZ (1) | CZ294412B6 (pt) |
| DE (1) | DE69616515T2 (pt) |
| DK (1) | DK0811001T3 (pt) |
| EE (1) | EE03564B1 (pt) |
| ES (1) | ES2167544T3 (pt) |
| FI (1) | FI973380A (pt) |
| GE (1) | GEP20001969B (pt) |
| HU (1) | HUP9800273A3 (pt) |
| NO (1) | NO308897B1 (pt) |
| NZ (1) | NZ302116A (pt) |
| PL (1) | PL321866A1 (pt) |
| PT (1) | PT811001E (pt) |
| RO (1) | RO116898B1 (pt) |
| RU (1) | RU2164225C2 (pt) |
| SK (1) | SK284275B6 (pt) |
| UA (1) | UA47424C2 (pt) |
| WO (1) | WO1996026195A1 (pt) |
| ZA (1) | ZA961342B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6030991A (en) * | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| EP0838223B1 (en) * | 1995-06-02 | 2003-07-23 | Shionogi & Co., Ltd. | Brain edema inhibitor |
| US5804585A (en) * | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
| US5783705A (en) * | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| HU227183B1 (en) | 1997-04-28 | 2010-09-28 | Encysive Pharmaceuticals Inc | Sulfonamide derivatives and pharmaceutical compositions containing them for the treatment of endothelin-mediated disorders |
| CA2295239A1 (en) | 1997-06-27 | 1999-01-07 | Fujisawa Pharmaceutical Co., Ltd. | Sulfonamide compounds and medicinal use thereof |
| JP2001515893A (ja) * | 1997-09-05 | 2001-09-25 | ワーナー−ランバート・カンパニー | 特定のベンゾチアジンジオキシドエンドセリンアンタゴニスト類およびその製造方法 |
| GB2337048B (en) * | 1998-05-05 | 2000-06-28 | Warner Lambert Co | 2,1,3-Benzothiadiazole containing endothelin antagonists |
| CA2409927A1 (en) * | 2000-05-31 | 2001-12-06 | Warner-Lambert Company | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
| US20020115661A1 (en) * | 2000-12-07 | 2002-08-22 | Keller Laurence Harvey | Method for treating chronic obstructive pulmonary disease |
| BRPI0709950A2 (pt) * | 2006-04-13 | 2011-08-02 | Actelion Pharmaceuticals Ltd | uso de bosentan na preparação de um medicamento para o tratamento de fibrose pulmonar idiopática em estágio precoce e uso de antagonista do receptor endotelin |
| FR2942797B1 (fr) * | 2009-03-03 | 2011-04-29 | Pf Medicament | Derives de benzothiazines, leur preparation et leur application a titre de medicaments |
| JP7065081B2 (ja) | 2016-09-12 | 2022-05-11 | インテグラル ヘルス， インコーポレイテッド | Ｇｐｒ１２０モジュレーターとして有用な二環式化合物 |
| CN112521384B (zh) * | 2021-01-13 | 2021-11-02 | 湖北大学 | 溶剂热一锅法合成苯并噻嗪并环戊二烯衍生物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3237473A1 (de) * | 1982-10-09 | 1984-04-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltende arzneimittel |
| CA2032559C (en) * | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
| JPH0441483A (ja) * | 1990-06-07 | 1992-02-12 | Tanabe Seiyaku Co Ltd | ベンゾチアジン誘導体及びその製法 |
| WO1993008799A1 (en) * | 1991-11-05 | 1993-05-13 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| US5389620A (en) * | 1993-08-18 | 1995-02-14 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
-
1995
- 1995-02-21 US US08/393,143 patent/US5599811A/en not_active Expired - Fee Related
-
1996
- 1996-01-26 CA CA002211027A patent/CA2211027A1/en not_active Abandoned
- 1996-01-26 PL PL96321866A patent/PL321866A1/xx unknown
- 1996-01-26 AT AT96903708T patent/ATE207911T1/de not_active IP Right Cessation
- 1996-01-26 RU RU97116154/04A patent/RU2164225C2/ru not_active IP Right Cessation
- 1996-01-26 CZ CZ19972607A patent/CZ294412B6/cs not_active IP Right Cessation
- 1996-01-26 JP JP8525692A patent/JPH11501013A/ja not_active Abandoned
- 1996-01-26 EE EE9700147A patent/EE03564B1/xx not_active IP Right Cessation
- 1996-01-26 DE DE69616515T patent/DE69616515T2/de not_active Expired - Fee Related
- 1996-01-26 AU AU47703/96A patent/AU720036B2/en not_active Ceased
- 1996-01-26 CN CN96192042A patent/CN1071327C/zh not_active Expired - Fee Related
- 1996-01-26 SK SK1146-97A patent/SK284275B6/sk unknown
- 1996-01-26 EP EP96903708A patent/EP0811001B1/en not_active Expired - Lifetime
- 1996-01-26 UA UA97094674A patent/UA47424C2/uk unknown
- 1996-01-26 ES ES96903708T patent/ES2167544T3/es not_active Expired - Lifetime
- 1996-01-26 WO PCT/US1996/001093 patent/WO1996026195A1/en active IP Right Grant
- 1996-01-26 RO RO97-01580A patent/RO116898B1/ro unknown
- 1996-01-26 DK DK96903708T patent/DK0811001T3/da active
- 1996-01-26 GE GEAP19963855A patent/GEP20001969B/en unknown
- 1996-01-26 HU HU9800273A patent/HUP9800273A3/hu unknown
- 1996-01-26 KR KR1019970705755A patent/KR19980702358A/ko not_active Application Discontinuation
- 1996-01-26 PT PT96903708T patent/PT811001E/pt unknown
- 1996-02-20 ZA ZA961342A patent/ZA961342B/xx unknown
-
1997
- 1997-08-18 FI FI973380A patent/FI973380A/fi unknown
- 1997-08-20 NO NO973822A patent/NO308897B1/no not_active IP Right Cessation
- 1997-08-21 NZ NZ302116A patent/NZ302116A/en unknown
- 1997-09-01 BG BG101867A patent/BG62613B1/bg unknown
Also Published As
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