ES2154002T3 - 2-naftoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents

2-naftoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Info

Publication number
ES2154002T3
ES2154002T3 ES97108013T ES97108013T ES2154002T3 ES 2154002 T3 ES2154002 T3 ES 2154002T3 ES 97108013 T ES97108013 T ES 97108013T ES 97108013 T ES97108013 T ES 97108013T ES 2154002 T3 ES2154002 T3 ES 2154002T3
Authority
ES
Spain
Prior art keywords
medicinal
naftoilguanidins
substituted
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97108013T
Other languages
English (en)
Inventor
Joachim Dr Brendel
Heinz-Werner Dr Kleemann
Heinrich Christian Dr Englert
Hans Jochen Dr Lang
Jan-Robert Dr Schwark
Andreas Dr Weichert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2154002T3 publication Critical patent/ES2154002T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

2 R1 HASTA R8 LOS SIGNIFICADOS MENCIONADOS EN LA REIVINDICACION 1, QUE, COMO MEDICAMENTOS ANTIARRITMICOS CON COMPONENTE CARDIOPROTECTOR, SON IDONEAS PARA LA PROFILAXIS DEL INFARTO Y EL TRATAMIENTO DEL MISMO, ASI COMO PARA EL TRATAMIENTO DE LA ANGINA DE PECHO. TAMBIEN INHIBEN DE FORMA PREVENTIVA LOS PROCESOS PATOFISIOLOGICOS EN CASO DE DAÑOS INDUCIDOS POR ISQUEMA, EN PARTICULAR EN ARRITMIAS CARDIACAS INDUCIDAS POR ISQUEMIA.
ES97108013T 1996-05-29 1997-05-16 2-naftoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. Expired - Lifetime ES2154002T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19621483A DE19621483A1 (de) 1996-05-29 1996-05-29 Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
ES2154002T3 true ES2154002T3 (es) 2001-03-16

Family

ID=7795549

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97108013T Expired - Lifetime ES2154002T3 (es) 1996-05-29 1997-05-16 2-naftoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Country Status (29)

Country Link
US (1) US6087304A (es)
EP (1) EP0810206B1 (es)
JP (1) JP4039588B2 (es)
KR (1) KR970074776A (es)
CN (1) CN1167759A (es)
AR (1) AR008373A1 (es)
AT (1) ATE198320T1 (es)
AU (1) AU710065B2 (es)
BR (1) BR9703338A (es)
CA (1) CA2206366C (es)
CZ (1) CZ163097A3 (es)
DE (2) DE19621483A1 (es)
DK (1) DK0810206T3 (es)
ES (1) ES2154002T3 (es)
GR (1) GR3035126T3 (es)
HR (1) HRP970292B1 (es)
HU (1) HUP9700955A3 (es)
ID (1) ID16989A (es)
IL (1) IL120924A (es)
NO (1) NO308527B1 (es)
NZ (1) NZ314915A (es)
PL (1) PL185754B1 (es)
PT (1) PT810206E (es)
RU (1) RU2190600C2 (es)
SI (1) SI0810206T1 (es)
SK (1) SK282020B6 (es)
TR (1) TR199700428A2 (es)
TW (1) TW416944B (es)
ZA (1) ZA974665B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19621482A1 (de) 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6395897B1 (en) 1999-03-02 2002-05-28 Boehringer Ingelheim Pharmaceuticals, Inc. Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
AR039156A1 (es) * 2002-03-28 2005-02-09 Novartis Ag Amidas del acido piperidinilamino sulfamico o piperazinil sulfamico y su uso para la manufactura de un medicamento en enfermedades mediadas por la accion de la sulfatasa esteroide
EP1755593B1 (en) * 2004-06-02 2008-01-16 F.Hoffmann-La Roche Ag Naphthalene derivatives useful as histamine-3-receptor ligands
TW200614995A (en) * 2004-11-10 2006-05-16 Nicholas Piramal India Ltd Tricyclic guanidine derivatives as sodium-proton exchange inhibitors
AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
US8669280B2 (en) 2005-06-24 2014-03-11 Biotron Limited Antiviral compounds and methods
ATE478847T1 (de) * 2006-09-15 2010-09-15 Pfizer Substituierte pyridylmethylbicyclocarboxyamidverbindungen
WO2010090305A1 (ja) * 2009-02-09 2010-08-12 アステラス製薬株式会社 置換アシルグアニジン誘導体
EP2394987A4 (en) * 2009-02-09 2012-09-05 Astellas Pharma Inc ACYLGUANIDINDERIVAT
TW201116281A (en) * 2009-08-06 2011-05-16 Astellas Pharma Inc N atom containing ring acylguanidine derivatives
KR20140003484A (ko) 2011-02-02 2014-01-09 아스테라스 세이야쿠 가부시키가이샤 테트라히드로이소퀴놀린 유도체

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251545A (en) * 1979-09-19 1981-02-17 Gaf Corporation Fungicidal process using 1-(alkoxyaroyl)guanidines
IT1238227B (it) * 1989-12-01 1993-07-12 Modulo di smistamento per impianti di convogliamento a nastro e simili
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4415873A1 (de) * 1994-05-05 1995-11-09 Hoechst Ag Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
JPH08225513A (ja) * 1994-12-21 1996-09-03 Kanebo Ltd ナフトイルグアニジン誘導体
DE19621482A1 (de) * 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
TW416944B (en) 2001-01-01
SK67097A3 (en) 1997-12-10
DE19621483A1 (de) 1997-12-04
AU710065B2 (en) 1999-09-16
US6087304A (en) 2000-07-11
RU2190600C2 (ru) 2002-10-10
AR008373A1 (es) 2000-01-19
CZ163097A3 (cs) 1998-06-17
PT810206E (pt) 2001-06-29
SK282020B6 (sk) 2001-10-08
BR9703338A (pt) 1998-08-18
KR970074776A (ko) 1997-12-10
JP4039588B2 (ja) 2008-01-30
EP0810206B1 (de) 2000-12-27
JPH1081664A (ja) 1998-03-31
GR3035126T3 (en) 2001-03-30
HU9700955D0 (en) 1997-07-28
IL120924A0 (en) 1997-09-30
NO972433D0 (no) 1997-05-28
NZ314915A (en) 1998-02-26
SI0810206T1 (en) 2001-04-30
CA2206366C (en) 2008-02-19
ID16989A (id) 1997-11-27
DK0810206T3 (da) 2001-02-26
AU2364597A (en) 1997-12-04
ZA974665B (en) 1997-12-01
ATE198320T1 (de) 2001-01-15
IL120924A (en) 2002-03-10
HUP9700955A3 (en) 1998-04-28
HRP970292A2 (en) 1998-04-30
CA2206366A1 (en) 1997-11-29
TR199700428A2 (xx) 1997-12-21
NO308527B1 (no) 2000-09-25
EP0810206A1 (de) 1997-12-03
DE59702802D1 (de) 2001-02-01
HUP9700955A2 (hu) 1998-03-02
HRP970292B1 (en) 2001-08-31
PL318723A1 (en) 1997-12-08
PL185754B1 (pl) 2003-07-31
MX9703922A (es) 1997-11-29
NO972433L (no) 1997-12-01
CN1167759A (zh) 1997-12-17

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