ES2088388T3 - Composiciones de macrolido para el tratamiento de trastornos de movilidad gastrointestinal. - Google Patents

Composiciones de macrolido para el tratamiento de trastornos de movilidad gastrointestinal.

Info

Publication number
ES2088388T3
ES2088388T3 ES89303813T ES89303813T ES2088388T3 ES 2088388 T3 ES2088388 T3 ES 2088388T3 ES 89303813 T ES89303813 T ES 89303813T ES 89303813 T ES89303813 T ES 89303813T ES 2088388 T3 ES2088388 T3 ES 2088388T3
Authority
ES
Spain
Prior art keywords
macrolid
compositions
treatment
mobility disorders
gastrointestinal mobility
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89303813T
Other languages
English (en)
Inventor
Jaswant Singh Gidda
Herbert Andrew Kirst
David Wayne Robertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2088388T3 publication Critical patent/ES2088388T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPOSICIONES FARMACEUTICAS QUE TIENEN COMO INGREDIENTE ACTIVO UN MACROLIDO DE ANILLO CONTRAIDO. LOS MACROLIDOS, ALGUNOS DE LOS CUALES SON COMPUESTOS NUEVOS, MEJORAN LA MOTILIDAD GASTROINTESTINAL. TAMBIEN SE PROPORCIONAN METODOS PARA TRATAR DESORDENES DE MOTILIDAD GASTROINTESTINAL CON ESTOS MACROLIDOS Y PROCEDIMIENTOS PARA SU OBTENCION.
ES89303813T 1988-04-18 1989-04-18 Composiciones de macrolido para el tratamiento de trastornos de movilidad gastrointestinal. Expired - Lifetime ES2088388T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/182,645 US4920102A (en) 1988-04-18 1988-04-18 Method for treating gastrointestinal disorders

Publications (1)

Publication Number Publication Date
ES2088388T3 true ES2088388T3 (es) 1996-08-16

Family

ID=22669415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89303813T Expired - Lifetime ES2088388T3 (es) 1988-04-18 1989-04-18 Composiciones de macrolido para el tratamiento de trastornos de movilidad gastrointestinal.

Country Status (22)

Country Link
US (1) US4920102A (es)
EP (1) EP0349100B1 (es)
JP (1) JPH0825882B2 (es)
KR (1) KR970009580B1 (es)
CN (1) CN1023017C (es)
AR (1) AR244699A1 (es)
AT (1) ATE139782T1 (es)
AU (1) AU616746B2 (es)
CA (1) CA1328257C (es)
DE (1) DE68926728T2 (es)
DK (1) DK183589A (es)
ES (1) ES2088388T3 (es)
GR (1) GR3020604T3 (es)
HU (1) HU206365B (es)
IE (1) IE72969B1 (es)
IL (1) IL89996A (es)
MX (1) MX15701A (es)
NZ (1) NZ228768A (es)
PH (1) PH26391A (es)
PT (1) PT90293B (es)
RU (1) RU2086560C1 (es)
ZA (1) ZA892801B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
US5068221A (en) * 1989-05-09 1991-11-26 Mathias John R Treatment of motility disorders with a gnrh analog
US5434136A (en) * 1990-12-14 1995-07-18 Mathias; John R. Treatment of motility disorders with a GNRH analog
KR100222014B1 (ko) * 1991-04-09 1999-10-01 스티븐 에프. 웨인스톡 거대환식 락탐 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
US5554605A (en) * 1991-04-09 1996-09-10 Abbott Laboratories Macrocyclic lactam prokinetic agents
DE4200145A1 (de) * 1992-01-07 1993-07-08 Kali Chemie Pharma Gmbh 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ES2115760T3 (es) * 1992-01-21 1998-07-01 Abbott Lab Derivados de 4''-desoxieritromicina.
US5470961A (en) * 1992-03-19 1995-11-28 Takeda Chemical Ind., Ltd. 14 and/or 15-hydroxy 6,9 hemiacetal erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5712253A (en) * 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
DE19644195A1 (de) * 1996-10-24 1998-04-30 Solvay Pharm Gmbh 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
DE19805822B4 (de) * 1998-02-13 2009-02-05 Solvay Pharmaceuticals Gmbh 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5972898A (en) * 1998-03-27 1999-10-26 Abbott Laboratories 3',3-N-bis-substituted macrolide LHRH antagonists
US5955440A (en) * 1998-03-27 1999-09-21 Abbott Laboratories Macrolide LHRH antagonists
US6020521A (en) * 1998-08-26 2000-02-01 Abbott Laboratories Macrolide LHRH antagonists
US6387885B1 (en) 1998-08-26 2002-05-14 Abbott Laboratories 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists
US6451806B2 (en) 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
ATE321770T1 (de) * 2000-08-17 2006-04-15 Kitasato Inst Pseudoerythromycin-derivate
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
US20040067896A1 (en) * 2002-07-25 2004-04-08 The Kitasato Institute Novel pseudoerythromycin derivatives
EP1559719A4 (en) * 2002-10-29 2006-12-20 Kitasato Inst NEW ANTIMYCOTIC ACTIVITY REINFORCING MAKROLIDE DERIVATIVES
EP1633774B1 (en) 2003-06-18 2010-02-17 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
NZ568763A (en) * 2005-12-08 2010-04-30 Pfizer Method for demethylating the 3'-dimethylamino group of erythromycin compounds
CN101528765B (zh) 2006-09-11 2015-04-22 欧塞拉治疗有限公司 用于治疗胃肠动力障碍病症的促胃动素受体的大环拮抗剂
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
FR2995605B1 (fr) * 2012-09-18 2014-09-19 Sanofi Sa Derives de macrolides, leur preparation et leur application therapeutique.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547491A (en) * 1984-07-18 1985-10-15 Merck & Co., Inc. C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use
JPS6187625A (ja) * 1984-10-05 1986-05-06 Satoshi Omura 消化管収縮運動促進剤
DE3689758T2 (de) * 1985-08-31 1994-08-18 Kitasato Inst Erythromycinderivat und Verfahren zu dessen Herstellung.
CA1321581C (en) * 1987-05-26 1993-08-24 Herbert A. Kirst Ring-contracted macrolides

Also Published As

Publication number Publication date
JPH0825882B2 (ja) 1996-03-13
DE68926728T2 (de) 1996-11-28
AU3310789A (en) 1989-10-19
US4920102A (en) 1990-04-24
RU2086560C1 (ru) 1997-08-10
KR970009580B1 (en) 1997-06-14
MX15701A (es) 1993-11-01
DK183589A (da) 1989-10-19
IL89996A (en) 1994-08-26
EP0349100A2 (en) 1990-01-03
ATE139782T1 (de) 1996-07-15
AR244699A1 (es) 1993-11-30
HU206365B (en) 1992-10-28
IL89996A0 (en) 1989-12-15
CN1023017C (zh) 1993-12-08
DE68926728D1 (de) 1996-08-01
DK183589D0 (da) 1989-04-17
PT90293B (pt) 1994-07-29
IE891224L (en) 1989-10-18
PH26391A (en) 1992-07-02
EP0349100B1 (en) 1996-06-26
ZA892801B (en) 1990-12-28
KR900016220A (ko) 1990-11-12
JPH01311096A (ja) 1989-12-15
CN1037517A (zh) 1989-11-29
AU616746B2 (en) 1991-11-07
PT90293A (pt) 1989-11-10
HUT49625A (en) 1989-10-30
CA1328257C (en) 1994-04-05
NZ228768A (en) 1990-10-26
IE72969B1 (en) 1997-05-07
GR3020604T3 (en) 1996-10-31
EP0349100A3 (en) 1991-11-13

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