ES2102043T3 - Derivados de 22-en-25-oxa en la serie de la vitamina d, procedimiento para su preparacion, preparados farmaceuticos que los contienen, asi como su utilizacion en calidad de medicamentos. - Google Patents
Derivados de 22-en-25-oxa en la serie de la vitamina d, procedimiento para su preparacion, preparados farmaceuticos que los contienen, asi como su utilizacion en calidad de medicamentos.Info
- Publication number
- ES2102043T3 ES2102043T3 ES93915800T ES93915800T ES2102043T3 ES 2102043 T3 ES2102043 T3 ES 2102043T3 ES 93915800 T ES93915800 T ES 93915800T ES 93915800 T ES93915800 T ES 93915800T ES 2102043 T3 ES2102043 T3 ES 2102043T3
- Authority
- ES
- Spain
- Prior art keywords
- vitamin
- series
- preparation
- oxa
- medicines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940088594 vitamin Drugs 0.000 title abstract 2
- 229930003231 vitamin Natural products 0.000 title abstract 2
- 235000013343 vitamin Nutrition 0.000 title abstract 2
- 239000011782 vitamin Substances 0.000 title abstract 2
- 150000003722 vitamin derivatives Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- -1 METHYL GROUP Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE AL DERIVADO 22 LA SERIA DE LA VITAMINA D DE LA FORMULA GENERAL (I), DONDE R1, R2 Y R3 DE FORMA INDEPENDIENTE UNO DE OTRO SIGNIFICAN UN ATOMO DE HIDROGENO, UN GRUPO ALCANOIL CON 1 HASTA 9 ATOMOS DE CARBONO ASI COMO UN GRUPO AROIL, R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUIL LINEAL O RAMIFICADO CON 1 HASTA 4 ATOMOS DE CARBONO, UN GRUPO TRIFLUOR METIL O UN ANILLO DE 3,4,5 O 6 MIEMBROS FORMADO CONJUNTAMENTE CON EL ATOMO DE CARBONO TERCIARIO, SIENDO CICLICO O HETEROCICLICO, SATURADO O NO SATURADO Y X SIGNIFICA UN RESTO ALQUIL SU ELABORACION Y SU UTILIZACION FARMACEUTICA PARA TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4221961A DE4221961A1 (de) | 1992-06-30 | 1992-06-30 | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2102043T3 true ES2102043T3 (es) | 1997-07-16 |
Family
ID=6462459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93915800T Expired - Lifetime ES2102043T3 (es) | 1992-06-30 | 1993-06-30 | Derivados de 22-en-25-oxa en la serie de la vitamina d, procedimiento para su preparacion, preparados farmaceuticos que los contienen, asi como su utilizacion en calidad de medicamentos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5663157A (es) |
EP (1) | EP0649405B1 (es) |
JP (1) | JP3589664B2 (es) |
AT (1) | ATE150745T1 (es) |
DE (2) | DE4221961A1 (es) |
DK (1) | DK0649405T3 (es) |
ES (1) | ES2102043T3 (es) |
GR (1) | GR3023437T3 (es) |
WO (1) | WO1994000429A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
DE19744127B4 (de) * | 1997-10-01 | 2006-10-05 | Schering Ag | Neue Vitamin D-Derivate mit Cyclopropylringen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln |
EP1233942A2 (en) * | 1999-12-02 | 2002-08-28 | The Penn State Research Foundation | Treatment of inflammatory bowel disease with vitamin d compounds |
US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
US6358939B1 (en) * | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
US6989377B2 (en) * | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
IL153378A0 (en) * | 2000-07-18 | 2003-07-06 | Bone Care Internat Inc | STABILIZED 1alpha-HYDROXY VITAMIN D |
US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
JP5932339B2 (ja) | 2009-01-27 | 2016-06-08 | バーグ エルエルシー | 化学療法に付随する副作用を軽減するためのビタミンd3およびその類似体 |
IN2012DN02137A (es) | 2009-08-14 | 2015-08-07 | Berg Biosystems Llc | |
SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3276167D1 (en) * | 1981-11-02 | 1987-06-04 | Res Inst Medicine Chem | Intermediates in the synthesis of vitamin d derivatives |
US4594432A (en) * | 1983-01-28 | 1986-06-10 | Hoffman-La Roche Inc. | Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol |
US4719205A (en) * | 1984-01-30 | 1988-01-12 | Wisconsin Alumini Research Foundation | Side-chain unsaturated 1-hydroxyvitamin D compounds |
JPS6144860A (ja) * | 1984-08-10 | 1986-03-04 | Taisho Pharmaceut Co Ltd | 1α.25−ジヒドロキシ−26.27−ジメチルビタミンD↓3 |
JPS6172652A (ja) * | 1984-09-14 | 1986-04-14 | Asahi Glass Co Ltd | 歯科材料用リン酸カルシウム系結晶性ガラス |
US4612308A (en) * | 1984-11-29 | 1986-09-16 | Hoffmann-La Roche Inc. | 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers |
ATE45347T1 (de) * | 1985-05-30 | 1989-08-15 | Taisho Pharmaceutical Co Ltd | Vitamin d3-derivate. |
US4832875A (en) * | 1985-11-21 | 1989-05-23 | Taisho Pharmaceutical Co., Ltd. | Vitamin D3 derivative |
JPH0764804B2 (ja) * | 1986-04-25 | 1995-07-12 | 住友製薬株式会社 | 活性型ビタミンd3のフッ素誘導体 |
US4853378A (en) * | 1986-10-20 | 1989-08-01 | Sumitomo Chemical Company, Limited | Fluorine derivatives of vitamin D3 and process for producing the same |
DE3865544D1 (de) * | 1987-06-23 | 1991-11-21 | Yamanouchi Pharma Co Ltd | Vitamin d3-derivate. |
US5145846A (en) * | 1988-01-20 | 1992-09-08 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
US5087619A (en) * | 1988-01-20 | 1992-02-11 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
KR0144358B1 (ko) * | 1988-04-21 | 1998-07-15 | 피. 라이달 크리스텐슨 | 비타민 d 동족체 |
EP0374219A1 (en) * | 1988-04-29 | 1990-06-27 | Wisconsin Alumni Research Foundation | SIDE CHAIN UNSATURATED 1$g(a)-HYDROXYVITAMIN D HOMOLOGS |
US4927815A (en) * | 1988-04-29 | 1990-05-22 | Wisconsin Alumni Research Foundation | Compounds effective in inducing cell differentiation and process for preparing same |
US4851401A (en) * | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
US5401732A (en) * | 1989-02-23 | 1995-03-28 | Leo Pharmaceutical Products Ltd. A/S Kemiske Fabrik Produkionsaktiese Skab | Vitamin D analogues |
US5401731A (en) * | 1989-06-29 | 1995-03-28 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) | Vitamin D analogues |
GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
EP0441467B1 (de) * | 1990-02-06 | 1994-06-01 | Schering Aktiengesellschaft | Seitenketten-homologe Vitamin-D-Derivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate, sowie deren Verwendung als Arzneimittel |
US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
DE4011682A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | 24-oxa-derivate in der vitamin d-reihe |
US5206230A (en) * | 1991-06-05 | 1993-04-27 | Daikin Industries, Ltd. | Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same |
US5278155A (en) * | 1991-06-05 | 1994-01-11 | Daikin Industries, Ltd. | Fluorine-containing vitamin D3 analogues and cell differentiation-inducing agent containing the same |
US5210237A (en) * | 1991-08-27 | 1993-05-11 | Daikin Industries, Ltd. | Vitamin d3 analogues |
US5200536A (en) * | 1992-02-10 | 1993-04-06 | Daikin Industries Ltd. | Fluorine-containing vitamin D3 analogues |
US5194431A (en) * | 1992-07-08 | 1993-03-16 | Wisconsin Alumni Research Foundation | 24-cyclopropane vitamin D derivatives |
-
1992
- 1992-06-30 DE DE4221961A patent/DE4221961A1/de not_active Withdrawn
-
1993
- 1993-06-30 US US08/362,438 patent/US5663157A/en not_active Expired - Fee Related
- 1993-06-30 EP EP93915800A patent/EP0649405B1/de not_active Expired - Lifetime
- 1993-06-30 AT AT93915800T patent/ATE150745T1/de not_active IP Right Cessation
- 1993-06-30 ES ES93915800T patent/ES2102043T3/es not_active Expired - Lifetime
- 1993-06-30 DK DK93915800.2T patent/DK0649405T3/da active
- 1993-06-30 WO PCT/EP1993/001735 patent/WO1994000429A1/de active IP Right Grant
- 1993-06-30 DE DE59305972T patent/DE59305972D1/de not_active Expired - Lifetime
- 1993-06-30 JP JP50206494A patent/JP3589664B2/ja not_active Expired - Fee Related
-
1997
- 1997-05-15 GR GR970401086T patent/GR3023437T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP3589664B2 (ja) | 2004-11-17 |
EP0649405B1 (de) | 1997-03-26 |
EP0649405A1 (de) | 1995-04-26 |
DE59305972D1 (de) | 1997-04-30 |
WO1994000429A1 (de) | 1994-01-06 |
DK0649405T3 (da) | 1997-09-29 |
ATE150745T1 (de) | 1997-04-15 |
US5663157A (en) | 1997-09-02 |
GR3023437T3 (en) | 1997-08-29 |
DE4221961A1 (de) | 1994-01-05 |
JPH07508515A (ja) | 1995-09-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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