ES2075976T3 - Derivados de aminoacido y su empleo como agentes antiviricos. - Google Patents

Derivados de aminoacido y su empleo como agentes antiviricos.

Info

Publication number
ES2075976T3
ES2075976T3 ES92107090T ES92107090T ES2075976T3 ES 2075976 T3 ES2075976 T3 ES 2075976T3 ES 92107090 T ES92107090 T ES 92107090T ES 92107090 T ES92107090 T ES 92107090T ES 2075976 T3 ES2075976 T3 ES 2075976T3
Authority
ES
Spain
Prior art keywords
formula
alkyl
alkoxycarbonyl
aralkanoyl
heterocyclylcarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92107090T
Other languages
English (en)
Inventor
Joseph Armstrong Martin
Gareth John Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919110170A external-priority patent/GB9110170D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2075976T3 publication Critical patent/ES2075976T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I) EN LA QUE R1 REPRESENTA ALCOXICARBONIL, ARALCOXICARBONIL, ALCANOIL, ARALCANOIL, ETEROCICLILCARBONIL O UN GRUPO DE LA FORMULA (I); R2 REPRESENTA ALQUIL, CICLOALQUILALQUIL O ARALQUIL; R3 REPRESENTA HIDROGENO Y R4 REPRESENTA HIDROXIDO O R3 Y R4 JUNTAS REPRESENTAN OXO; R5 REPRESENTA ALCOXICARBONIL O ALQUILCARBAMOIL; R6 Y R7 REPRESENTAN JUNTAS TRIMETILENO O TETRAMETILENO OPCIONALMENTE SUBSTITUIDO POR ALQUIL O SOBRE LOS ATOMOS DE CARBONO ADYACENTES POR TETRAMETILENO; R8 REPRESENTA ALCOXICARBONIL, ARALCOXICARBONIL, ALCANOIL, AROIL, ARALCANOIL, O HETEROCICLILCARBONIL; Y R9 REPRESENTA ALQUIL, CICLOALQUIL, CICLOALQUILALQUIL, ARALQUIL, CIANOALQUIL, CARBAMOILALQUIL, ALQUILTIOALQUIL, ALCOXIALQUIL O ALCOXICARBONILALQUIL, ASI MISMO SE PRESENTAN LAS SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLES DE ESTOS COMPUESTOS QUE SON BASICAS, INHIBEN LA PROTEASA ASPARTIL DE ORIGEN VIRAL Y PUEDEN USARSE EN FORMA DE MEDICAMENTOS PARA LA PROFILAXIS Y TRATAMIENTO DE INFECCIONES VIRALES. LOS COMPUESTOS PUEDEN MANUFACTURARSE DE ACUERDO CON METODOS GENERALMENTE CONOCIDOS.
ES92107090T 1991-05-10 1992-04-25 Derivados de aminoacido y su empleo como agentes antiviricos. Expired - Lifetime ES2075976T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919110170A GB9110170D0 (en) 1991-05-10 1991-05-10 Amino acid derivatives
GB929203014A GB9203014D0 (en) 1991-05-10 1992-02-13 Amino acid derivatives

Publications (1)

Publication Number Publication Date
ES2075976T3 true ES2075976T3 (es) 1995-10-16

Family

ID=26298885

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92107090T Expired - Lifetime ES2075976T3 (es) 1991-05-10 1992-04-25 Derivados de aminoacido y su empleo como agentes antiviricos.

Country Status (24)

Country Link
US (2) US5430041A (es)
EP (1) EP0512343B1 (es)
JP (1) JPH06102639B2 (es)
AT (1) ATE125792T1 (es)
AU (1) AU660308B2 (es)
CA (1) CA2067690C (es)
CZ (1) CZ281839B6 (es)
DE (1) DE69203780T2 (es)
DK (1) DK0512343T3 (es)
DZ (1) DZ1578A1 (es)
ES (1) ES2075976T3 (es)
FI (2) FI110938B (es)
GR (1) GR3017902T3 (es)
HR (1) HRP931025B1 (es)
HU (1) HU210283B (es)
IE (1) IE69169B1 (es)
IL (3) IL101770A (es)
IS (1) IS1747B (es)
MX (1) MX9202146A (es)
MY (1) MY108770A (es)
NO (1) NO300496B1 (es)
NZ (1) NZ242593A (es)
RO (1) RO109540B1 (es)
SK (1) SK281183B6 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
WO1993018006A1 (en) * 1992-03-11 1993-09-16 Narhex Limited Amine derivatives of oxo- and hydroxy-substitued hydrocarbons
MX9308016A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.
US5733906A (en) * 1993-10-12 1998-03-31 Eli Lilly And Company Inhibitors of HIV Protease useful for the treatment of Aids
US5491166A (en) * 1992-12-22 1996-02-13 Eli Lilly And Company Inhibitors of HIV protease useful for the treatment of AIDS
US5591885A (en) * 1994-09-23 1997-01-07 Hoffman-La Roche Inc. Process for the preparation of halogenated α-aminoketone compounds
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
GB0123467D0 (en) 2001-09-28 2001-11-21 Hoffmann La Roche Carbocyclic HIV Protease inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE447633B (sv) * 1978-09-19 1986-12-01 Albany Int Corp Forfarande for separering och modul for genomforande av forfarandet
JPS63166826A (ja) * 1986-12-27 1988-07-11 Shin Etsu Chem Co Ltd 抗ヒトレトロウイルス剤
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
CA2012901A1 (en) * 1989-04-05 1990-10-05 Quirico Branca Amino acid derivatives
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
CN1071930A (zh) * 1991-07-10 1993-05-12 伊莱利利公司 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂

Also Published As

Publication number Publication date
GR3017902T3 (en) 1996-01-31
JPH06102639B2 (ja) 1994-12-14
CS138492A3 (en) 1992-11-18
MY108770A (en) 1996-11-30
CZ281839B6 (cs) 1997-02-12
HRP931025A2 (en) 1996-06-30
IE921490A1 (en) 1992-11-18
HUT61972A (en) 1993-03-29
HU9201514D0 (en) 1992-07-28
MX9202146A (es) 1992-11-01
RO109540B1 (ro) 1995-03-30
CA2067690C (en) 2005-09-06
ATE125792T1 (de) 1995-08-15
DE69203780T2 (de) 1995-12-07
FI990399A (fi) 1999-02-24
US5583248A (en) 1996-12-10
US5430041A (en) 1995-07-04
DK0512343T3 (da) 1995-10-16
NO300496B1 (no) 1997-06-09
AU1600792A (en) 1992-11-12
FI922094A (fi) 1992-11-11
FI990399A0 (fi) 1999-02-24
NO921828D0 (no) 1992-05-08
IL112900A0 (en) 1995-06-29
HU210283B (en) 1995-03-28
IL101770A0 (en) 1992-12-30
AU660308B2 (en) 1995-06-22
DZ1578A1 (fr) 2002-02-17
HRP931025B1 (en) 2000-06-30
IL112900A (en) 1997-06-10
IS3858A (is) 1992-11-11
CA2067690A1 (en) 1992-11-11
JPH05155834A (ja) 1993-06-22
IL101770A (en) 1996-06-18
IS1747B (is) 2000-07-11
NO921828L (no) 1992-11-11
DE69203780D1 (de) 1995-09-07
NZ242593A (en) 1994-06-27
EP0512343A3 (en) 1993-03-24
EP0512343B1 (en) 1995-08-02
FI110938B (fi) 2003-04-30
EP0512343A2 (en) 1992-11-11
IE69169B1 (en) 1996-08-07
FI922094A0 (fi) 1992-05-08
SK281183B6 (sk) 2001-01-18

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