ATE253050T1 - Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen - Google Patents
Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffenInfo
- Publication number
- ATE253050T1 ATE253050T1 AT93906370T AT93906370T ATE253050T1 AT E253050 T1 ATE253050 T1 AT E253050T1 AT 93906370 T AT93906370 T AT 93906370T AT 93906370 T AT93906370 T AT 93906370T AT E253050 T1 ATE253050 T1 AT E253050T1
- Authority
- AT
- Austria
- Prior art keywords
- oxo
- hydroxy
- amine derivatives
- substituted hydrocarbons
- enzymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPL130492 | 1992-03-11 | ||
PCT/AU1993/000103 WO1993018006A1 (en) | 1992-03-11 | 1993-03-11 | Amine derivatives of oxo- and hydroxy-substitued hydrocarbons |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE253050T1 true ATE253050T1 (de) | 2003-11-15 |
Family
ID=29274649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93906370T ATE253050T1 (de) | 1992-03-11 | 1993-03-11 | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
Country Status (5)
Country | Link |
---|---|
US (1) | US6258806B1 (de) |
KR (1) | KR950700897A (de) |
AT (1) | ATE253050T1 (de) |
DE (1) | DE69333270T2 (de) |
MX (1) | MXPA93002392A (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1217920C (zh) * | 2000-06-30 | 2005-09-07 | 艾兰制药公司 | 治疗早老性痴呆的化合物 |
BR0209985A (pt) * | 2001-05-22 | 2004-06-29 | Elan Pharm Inc | Composto e método para o tratamento de um paciente |
EP2353631A3 (de) * | 2004-04-23 | 2012-01-25 | Leonard Edward Forrest | Vorrichtung zur behandlung oder evakuierung von bandscheiben |
Family Cites Families (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3330857A (en) | 1963-07-01 | 1967-07-11 | Pfizer & Co C | N-carbazoylamino acid intermediates for polypeptides |
US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5252477A (en) | 1987-06-01 | 1993-10-12 | The United States Of America As Represented By The United States Department Of Health And Human Services | Human immunodeficiency virus specific proteolytic enzyme and a method for its synthesis and renaturation |
JPH03500772A (ja) | 1987-10-21 | 1991-02-21 | ジ・アップジョン・カンパニー | (1‐アミノ‐2‐ヒドロキシ‐2‐ヘテロサイクリック)エチル基を含有するレニン抑制物質類 |
AU3570089A (en) | 1988-05-03 | 1989-11-29 | Upjohn Company, The | Renin inhibitory peptides containing a substituted phenoxyacetyle group |
IL90218A0 (en) | 1988-05-13 | 1989-12-15 | Abbott Lab | Retroviral protease inhibitors |
US5248667A (en) | 1988-05-27 | 1993-09-28 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Method of treating psoriasis using synthetic peptide compositions |
CA1340748C (en) | 1988-07-13 | 1999-09-14 | Stephen Oroszlan | Synthetic hiv protease gene and method for its expression |
IL91307A0 (en) | 1988-08-24 | 1990-03-19 | Merck & Co Inc | Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them |
EP0361341A3 (de) | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutika für AIDS auf der Basis von HIV-Protease-Inhibitoren |
IL92011A0 (en) | 1988-10-19 | 1990-07-12 | Abbott Lab | Heterocyclic peptide renin inhibitors |
DE3840452A1 (de) | 1988-12-01 | 1990-06-07 | Hoechst Ag | (beta)-amino-boronsaeure-derivate |
DE3841520A1 (de) | 1988-12-09 | 1990-06-13 | Hoechst Ag | Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
US5215968A (en) | 1988-12-10 | 1993-06-01 | Hoechst Aktiengesellschaft | Dipeptide derivatives having an enzyme inhibitory action |
DE3842067A1 (de) | 1988-12-14 | 1990-06-21 | Hoechst Ag | Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
EP0374098A3 (de) | 1988-12-15 | 1991-05-02 | Ciba-Geigy Ag | Retrovirale Proteasehemmer |
DE3842197A1 (de) | 1988-12-15 | 1990-06-21 | Hoechst Ag | Rasch spaltbares substrat fuer die hiv-protease |
US5198426A (en) | 1988-12-30 | 1993-03-30 | Warner-Lambert Company | Renin inhibitors containing c-terminal dihydroxy amides |
CA2010531A1 (en) | 1989-03-06 | 1990-09-06 | Werner Neidhart | Amino acid derivatives |
US5086165A (en) | 1989-03-08 | 1992-02-04 | Washington University | Inhibitors of retroviral protease with a ketomethylene isosteric replaced amide bond |
AU5407190A (en) | 1989-04-18 | 1990-11-16 | Upjohn Company, The | Peptides having novel polar n-terminal groups |
DE3913272A1 (de) | 1989-04-22 | 1990-10-25 | Hoechst Ag | Dipeptid-derivate mit enzym-inhibitorischer wirkung |
US5256677A (en) | 1989-05-23 | 1993-10-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5151438A (en) | 1989-05-23 | 1992-09-29 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5212157A (en) | 1989-06-06 | 1993-05-18 | Bio-Mega, Inc. | Enzyme inhibitors |
US5126326A (en) | 1989-06-06 | 1992-06-30 | Bio-Mega, Inc. | Enzyme inhibiting peptide derivatives |
WO1991001327A1 (en) | 1989-07-19 | 1991-02-07 | The Upjohn Company | Peptides containing diamino-glycols as transition-state mimics |
EP0421109A3 (en) | 1989-09-11 | 1992-01-08 | American Cyanamid Company | Screening methods for protease inhibitors |
EP0428849A3 (en) | 1989-09-28 | 1991-07-31 | Hoechst Aktiengesellschaft | Retroviral protease inhibitors |
DE4033062A1 (de) | 1990-10-18 | 1992-04-23 | Merck Patent Gmbh | Aminosaeurederivate |
US5221665A (en) | 1989-10-27 | 1993-06-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | N-substituted amides |
WO1991006561A1 (en) | 1989-10-27 | 1991-05-16 | The Upjohn Company | Method for treating hiv and other retroviruses and compounds useful therefor |
AU638774B2 (en) | 1989-11-20 | 1993-07-08 | Eli Lilly And Company | Methods of treating retroviral infection |
US5254682A (en) | 1989-12-08 | 1993-10-19 | Merck & Co., Inc. | Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs |
US5194605A (en) | 1989-12-08 | 1993-03-16 | Merck & Co., Inc. | Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs |
GB8927915D0 (en) | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Novel alcohols |
DE3941235A1 (de) | 1989-12-14 | 1991-06-20 | Bayer Ag | Neue peptide, ihre herstellung und ihre verwendung in arzneimitteln |
CA2071972A1 (fr) | 1989-12-18 | 1991-06-19 | Bruno Guy | Composition pharmaceutique destinee au traitement ou a la prevention des infections retrovirales |
CA2032259A1 (en) | 1989-12-18 | 1991-06-19 | Wayne J. Thompson | Hiv protease inhibitors useful for the treatment of aids |
US5164300A (en) | 1989-12-28 | 1992-11-17 | Washington University | Method for determining activity of retroviral protease |
US5011910A (en) | 1989-12-28 | 1991-04-30 | Washington University | Reagent and method for determining activity of retroviral protease |
DE4001236A1 (de) | 1990-01-18 | 1991-07-25 | Bayer Ag | Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren |
US5221667A (en) | 1990-01-22 | 1993-06-22 | Warner-Lambert Company | Renin inhibiting peptides having an α-heteroatom amino acid at the P3 position |
CA2036397C (en) | 1990-02-23 | 2000-12-12 | Paul Cates Anderson | Hiv protease inhibitors containing derived amino acid units |
CA2036398C (en) | 1990-02-23 | 2000-06-13 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Hiv protease inhibiting agents |
CA2036413C (en) | 1990-02-23 | 2000-12-12 | Paul Cates Anderson | Hiv protease inhibitors |
GB9005829D0 (en) | 1990-03-15 | 1990-05-09 | Proteus Biotech Ltd | Synthetic polypeptides |
EP0532693A1 (de) | 1990-06-01 | 1993-03-24 | The Du Pont Merck Pharmaceutical Company | 1,4-diamino-2,3-dihydroxybutane |
IL98260A0 (en) | 1990-06-01 | 1992-06-21 | Ciba Geigy Ag | Hiv protease inhibiting oligopeptides,process for their preparation and pharmaceutical compositions containing them |
AU8205491A (en) | 1990-06-01 | 1991-12-31 | Du Pont Merck Pharmaceutical Company, The | 1,4-diamino-2,3-dihydroxybutanes |
US5248606A (en) | 1990-06-11 | 1993-09-28 | Dowelanco | Dna encoding inactive precursor and active forms of maize ribosome inactivating protein |
US5141735A (en) | 1990-06-18 | 1992-08-25 | Hoffman-La Roche, Inc. | Substituted amino-benzodiazepines having anitviral activity |
US5223633A (en) | 1990-06-30 | 1993-06-29 | Bayer Aktiengesellschaft | Preparation of sec. or tert. alcohols |
DE4021007A1 (de) | 1990-07-02 | 1992-01-09 | Hoechst Ag | Aminodiol-derivate |
EP0538366A1 (de) | 1990-07-06 | 1993-04-28 | Smithkline Beecham Corporation | Retrovirale protease inhibitoren |
EP0538374A4 (en) | 1990-07-06 | 1993-05-19 | Smith-Kline Beecham Corporation | Aspartic protease inhibitors |
AU8231391A (en) | 1990-07-06 | 1992-02-04 | Smithkline Beecham Corporation | Inhibitors of aspartic proteases |
EP0538396A1 (de) | 1990-07-06 | 1993-04-28 | Smithkline Beecham Corporation | Inhibitoren für proteasen von retroviren |
WO1992003472A1 (en) | 1990-08-24 | 1992-03-05 | The Upjohn Company | Peptides containing amino-polyols as transition-state mimics |
EP0475231A1 (de) | 1990-09-10 | 1992-03-18 | F. Hoffmann-La Roche Ag | Benzodiazepine |
US5171662A (en) | 1990-09-13 | 1992-12-15 | The Upjohn Company | Method of detecting HIV protease activity |
US5183826A (en) | 1990-09-25 | 1993-02-02 | Merck & Co., Inc. | Antiviral agent |
AU8759491A (en) | 1990-10-10 | 1992-05-20 | Upjohn Company, The | Peptides containing substituted 1,4-diamines as transition-state inserts |
US5188950A (en) | 1990-10-11 | 1993-02-23 | Merck & Co., Inc. | Method of preparing HIV protease inhibitors |
US5192668A (en) | 1990-10-11 | 1993-03-09 | Merck & Co., Inc. | Synthesis of protease inhibitor |
US5187074A (en) | 1990-10-11 | 1993-02-16 | Merck & Co., Inc. | Method of hydroxylation with ATCC 55086 |
US5137876A (en) | 1990-10-12 | 1992-08-11 | Merck & Co., Inc. | Nucleoside antiviral and anti-inflammatory compounds and compositions and methods for using same |
EP0483403A1 (de) | 1990-10-31 | 1992-05-06 | Hoechst Aktiengesellschaft | Aminsäurederivate mit renininhibierender Aktivität, Verfahren zu deren Herstellung und pharmazeutische Zubereitungen die sie enthalten |
ES2059296T3 (es) | 1990-11-19 | 1996-07-16 | Monsanto Co | Inhibidores de proteasas retrovirales. |
ATE164839T1 (de) | 1990-11-19 | 1998-04-15 | Monsanto Co | Retrovirale proteaseinhibitoren |
JPH06502859A (ja) | 1990-11-19 | 1994-03-31 | モンサント カンパニー | レトロウイルスプロテアーゼ阻害剤 |
DK0735019T3 (da) | 1990-11-19 | 2000-10-23 | Monsanto Co | Retrovirale proteaseinhibitorer |
IE20010533A1 (en) | 1990-11-20 | 2003-03-05 | Abbott Lab | Intermediates for preparing retroviral protease inhibiting compounds |
DE4037437A1 (de) | 1990-11-24 | 1992-05-27 | Hoechst Ag | Aminodiol-derivate |
EP0559793A1 (de) | 1990-11-30 | 1993-09-15 | Smithkline Beecham Corporation | Hiv-protease inhibitoren |
CA2056911C (en) | 1990-12-11 | 1998-09-22 | Yuuichi Nagano | Hiv protease inhibitors |
EP0491218A1 (de) | 1990-12-17 | 1992-06-24 | F. Hoffmann-La Roche Ag | Benzodiazepinone |
EP0492136A3 (en) | 1990-12-20 | 1993-05-26 | American Cyanamid Company | Retroviral protease inhibitors derived from 3-chloro-2-chloromethyl-1-propene |
HU210647B (en) | 1991-01-02 | 1995-06-28 | Merrell Dow Pharma | Process for producing antiviral difluoro-statone derivatives and pharmaceutical compositions containing them |
HUT60282A (en) | 1991-02-08 | 1992-08-28 | Sankyo Co | Process for producing new beta-amino-alpha-hydroxycarboxylic acid derivatives and pharmaceutical compositions comprising such compounds |
ZA921279B (en) | 1991-02-22 | 1993-08-23 | Du Pont Merck Pharma | Substituted alpha-aminoaldehydes and derivatives |
EP0578745A1 (de) | 1991-04-04 | 1994-01-19 | The Upjohn Company | Phosphorhaltige verbindungen als inhibitoren von retroviren |
US5430041A (en) | 1991-05-10 | 1995-07-04 | Hoffmann-La Roche Inc. | Amino acid derivatives having antiviral activity |
US5235039A (en) | 1991-06-10 | 1993-08-10 | Eli Lilly And Company | Substrates for hiv protease |
PL294866A1 (en) | 1991-06-21 | 1993-05-31 | Hoechst Ag | Method of obtaining novel rennin redtarding heterocyclic compounds |
PL294870A1 (de) | 1991-06-21 | 1993-02-08 | Hoechst Ag | |
US5169952A (en) | 1991-07-02 | 1992-12-08 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides |
IL102362A0 (en) | 1991-07-02 | 1993-01-14 | Sandoz Ag | 4-amino-3-hydroxycarboxylic acid derivatives,their production and pharmaceutical compositions containing them |
US5753652A (en) | 1991-07-03 | 1998-05-19 | Novartis Corporation | Antiretroviral hydrazine derivatives |
DE59207226D1 (de) | 1991-07-03 | 1996-10-31 | Ciba Geigy Ag | Pharmakologisch wirksame Hydrazinderivate und Verfahren zu deren Herstellung |
CN1071930A (zh) | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
IE922316A1 (en) | 1991-07-17 | 1993-01-27 | Smithkline Beecham Corp | Retroviral protease inhibitors |
US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
DE4126485A1 (de) | 1991-08-10 | 1993-02-11 | Bayer Ag | Trifluormethyl-haltige pseudopeptide |
US5516784A (en) | 1991-08-13 | 1996-05-14 | Schering Corporation | Anti-HIV (AIDS) agents |
DE4128790A1 (de) | 1991-08-30 | 1993-03-04 | Bayer Ag | Neue substituierte 2,3-diaminosaeuren, verfahren zu ihrer herstellung und ihre verwendung als zwischenstufen fuer peptidische wirkstoffe |
JPH06510766A (ja) | 1991-09-11 | 1994-12-01 | スミスクライン・ビーチャム・コーポレイション | H.i.v.阻害剤としてのヘテロ環含有ペプチド同配体 |
EP0532466A3 (en) | 1991-09-12 | 1993-06-16 | Ciba-Geigy Ag | Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use |
US5250563A (en) | 1991-09-25 | 1993-10-05 | Merck & Co., Inc. | Inhibitors of HIV protease |
WO1993008184A1 (en) | 1991-10-23 | 1993-04-29 | Merck & Co., Inc. | Hiv protease inhibitors |
ES2112880T3 (es) | 1991-11-08 | 1998-04-16 | Merck & Co Inc | Inhibidores de la proteasa de vih utiles para el tratamiento del sida. |
FR2683723B1 (fr) | 1991-11-14 | 1995-05-19 | Mayoly Spindler Laboratoires | Nouveaux medicaments antiviraux actifs sur le virus vih. |
CA2106387A1 (en) | 1992-02-26 | 1993-08-27 | Ming-Chu Hsu | Benzodiazepinones |
US5294737A (en) | 1992-02-27 | 1994-03-15 | The Research Foundation State University Of New York | Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom |
WO1993018006A1 (en) | 1992-03-11 | 1993-09-16 | Narhex Limited | Amine derivatives of oxo- and hydroxy-substitued hydrocarbons |
EP0560268B1 (de) | 1992-03-13 | 1995-01-04 | Bio-Mega/Boehringer Ingelheim Research Inc. | Substituierte Pipecoline-Säurederivate als HIV-Protease-Hemmer |
ZA931777B (en) | 1992-03-13 | 1993-09-23 | Bio Mega Boehringer Ingelheim | Substituted pyrrolidine derivatives as HIV protease inhibitors. |
TW217410B (de) | 1992-04-01 | 1993-12-11 | Ciba Geigy | |
US5231153A (en) | 1992-04-06 | 1993-07-27 | The Goodyear Tire & Rubber Company | Anionic polymerization of conjugated dienes modified with alkyltetrahydrofurfuryl ethers |
DE4215874A1 (de) | 1992-05-14 | 1993-11-18 | Bayer Ag | Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp |
US5296604A (en) | 1992-05-15 | 1994-03-22 | Miles Inc. | Proline derivatives and compositions for their use as inhibitors of HIV protease |
SI9300288A (sl) | 1992-06-16 | 1993-12-31 | Hoffmann La Roche | Benzodiazepini |
IL105973A0 (en) | 1992-06-19 | 1993-10-20 | Lilly Co Eli | Inhibitors of hiv protease useful for the treatment of aids |
US5559256A (en) | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
DE4232173A1 (de) | 1992-09-25 | 1994-03-31 | Bayer Ag | 5-Oxo-dibenzo(a,d)cyclohepta-1,4-diene |
TW372972B (en) | 1992-10-23 | 1999-11-01 | Novartis Ag | Antiretroviral acyl compounds |
DE59303870D1 (de) | 1992-12-23 | 1996-10-24 | Ciba Geigy Ag | Antiretrovirale hydrazinderivate |
DE4308096A1 (de) | 1993-03-13 | 1994-09-15 | Hoechst Ag | Prodrug-Derivate von Enzyminhibitoren mit Hydroxylgruppen, Verfahren zu deren Herstellung und ihre Verwendung |
-
1993
- 1993-03-11 DE DE69333270T patent/DE69333270T2/de not_active Expired - Fee Related
- 1993-03-11 MX MXPA93002392A patent/MXPA93002392A/es active IP Right Grant
- 1993-03-11 AT AT93906370T patent/ATE253050T1/de not_active IP Right Cessation
-
1994
- 1994-09-10 KR KR1019940703201A patent/KR950700897A/ko not_active IP Right Cessation
-
1999
- 1999-05-27 US US09/321,043 patent/US6258806B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69333270T2 (de) | 2004-08-05 |
US6258806B1 (en) | 2001-07-10 |
DE69333270D1 (de) | 2003-12-04 |
MXPA93002392A (es) | 2005-02-04 |
KR950700897A (ko) | 1995-02-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2130754A1 (en) | Amine derivatives of oxo- and hydroxy-substituted hydrocarbons | |
ES2106965T3 (es) | Nuevas 4-aza-5alfa-androstan-3-onas 7beta-sustituidas como inhibidores de 5alfa-reductasa. | |
TR200402157T2 (tr) | Heteroaril süksinamidler ve metalloproteinaz inhibitörü olarak kullanımları | |
NO990855L (no) | Substituerte sykliske amin-metallprotease-inhibitorer | |
DE69118907D1 (de) | Retrovirale proteaseinhibitoren | |
DE69129235D1 (de) | Retrovirale proteaseinhibitoren | |
DE69220744D1 (de) | 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung | |
KR950700323A (ko) | 엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 아미노아세틸머캅토아세틸아미드 유도체(Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE) | |
NO944406L (no) | Nye 7 e inhibitorer | |
ATE170868T1 (de) | Peptid-phosphinyloxymethyl-ketonen als inhibitoren von interleukin-1 beta- konvertierenden enzymen | |
EA200000320A1 (ru) | Изохинолины в качестве ингибиторов урокиназы | |
FI935777A0 (fi) | Inhibitorer foer HIV-proteas anvaendbara vid behandling av AIDS | |
DE69307674D1 (de) | HIV-Proteaseinhibitoren und ihre Verwendung zur Behandlung von AIDS | |
ATE253050T1 (de) | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen | |
PT950056E (pt) | N-(piridinilamino) isoindolinas e compostos relacionados | |
DE69808607D1 (de) | Verfahren zur verwendung von cyclooxygenase-2 hemmern zur behandlung und vorbeugung der demenz | |
ATE137973T1 (de) | Phospholipide zur behandlung der multiplen sklerose |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |