ES2135429T3 - Derivados de ciclohexano sustituidos para el tratamiento de enfermedades. - Google Patents
Derivados de ciclohexano sustituidos para el tratamiento de enfermedades.Info
- Publication number
- ES2135429T3 ES2135429T3 ES93114260T ES93114260T ES2135429T3 ES 2135429 T3 ES2135429 T3 ES 2135429T3 ES 93114260 T ES93114260 T ES 93114260T ES 93114260 T ES93114260 T ES 93114260T ES 2135429 T3 ES2135429 T3 ES 2135429T3
- Authority
- ES
- Spain
- Prior art keywords
- diseases
- treatment
- cyclohexane derivatives
- substituted cyclohexane
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical class C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 102000003638 Glucose-6-Phosphatase Human genes 0.000 abstract 1
- 108010086800 Glucose-6-Phosphatase Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical class [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/383—Cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Cyclones (AREA)
- Transceivers (AREA)
- Mobile Radio Communication Systems (AREA)
Abstract
SE DESCRIBEN ESTERES DE LOS DERIVADOS DE CICLOHEXANO DE FORMULA (I), EN DONDE A, B, R3, R4, R5 Y Y Z TIENEN UN SIGNIFICADO MENCIONADO PARA LA APLICACION COMO INHIBIDOR DEL SISTEMA GLUCOSA-6-FOSFATASA DEL HIGADO EN MAMIFEROS. LOS COMPUESTOS SON APROPIADOS PARA LA PRODUCCION DE PREPARADOS FARMACEUTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4230156 | 1992-09-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2135429T3 true ES2135429T3 (es) | 1999-11-01 |
Family
ID=6467599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93114260T Expired - Lifetime ES2135429T3 (es) | 1992-09-09 | 1993-09-06 | Derivados de ciclohexano sustituidos para el tratamiento de enfermedades. |
Country Status (23)
Country | Link |
---|---|
US (1) | US5451573A (es) |
EP (1) | EP0587087B1 (es) |
JP (1) | JPH06211737A (es) |
KR (1) | KR100299205B1 (es) |
CN (1) | CN1042329C (es) |
AT (1) | ATE181237T1 (es) |
AU (1) | AU662836B2 (es) |
CA (1) | CA2105707A1 (es) |
CZ (1) | CZ284995B6 (es) |
DE (1) | DE59309649D1 (es) |
DK (1) | DK0587087T3 (es) |
ES (1) | ES2135429T3 (es) |
FI (1) | FI933902A (es) |
GR (1) | GR3030953T3 (es) |
HK (1) | HK1011934A1 (es) |
HU (1) | HUT64843A (es) |
IL (1) | IL106935A (es) |
NO (1) | NO179671C (es) |
PH (1) | PH30278A (es) |
PL (1) | PL300328A1 (es) |
RU (1) | RU2131248C1 (es) |
TW (1) | TW255880B (es) |
ZA (1) | ZA936610B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4404848A1 (de) * | 1994-02-16 | 1995-08-17 | Hoechst Ag | Substituierte Cyclohexanolester, ihre Verwendung zur Behandlung von Krankheiten und pharmazeutische Präparate |
DE4408082A1 (de) * | 1994-03-10 | 1995-09-14 | Hoechst Ag | Substituierte Propan-Derivate, Verfahren zu ihrer Herstellung und die Anwendung der Verbindungen zur Behandlung von Krankheiten |
DE4416433A1 (de) * | 1994-05-10 | 1995-11-16 | Hoechst Ag | Cyclohexan-Derivate, Verfahren zu ihrer Herstellung und die Verwendung der Verbindungen zur Behandlung von Krankheiten |
AR012449A1 (es) * | 1997-04-18 | 2000-10-18 | Hoechst Marion Roussell Deutschland Gmbh | Kodaistatinas a, b, c y d, proceso para su produccion, y su uso. |
JP4810558B2 (ja) * | 1997-08-08 | 2011-11-09 | 江崎グリコ株式会社 | リン酸化糖およびその製造方法 |
DE19740080A1 (de) * | 1997-09-12 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Neue Phthalaldehyd-Derivate, Verfahren zu deren Herstellung und deren Verwendung |
RU2252211C2 (ru) * | 1999-10-25 | 2005-05-20 | Авентис Фарма Дойчланд Гмбх | Ароматические дикетопроизводные, способы получения и применение данных соединений в качестве фармацевтических средств |
EP1771431A1 (en) | 2004-06-03 | 2007-04-11 | Eisai Co., Ltd. | Intermediates for the preparation of halichondrin b |
CN101010276B (zh) * | 2004-07-26 | 2011-01-12 | 中外制药株式会社 | 环己烷衍生物、其前体药物及其盐、以及含有它的糖尿病治疗药 |
EP2200992B1 (en) | 2007-10-03 | 2014-02-26 | Eisai R&D Management Co., Ltd. | Intermediates and methods for the synthesis of halichondrin b analogs |
SG189739A1 (en) | 2008-04-04 | 2013-05-31 | Eisai R&D Man Co Ltd | Halichondrin b analogs |
US20100112098A1 (en) * | 2008-10-31 | 2010-05-06 | Naturex, S.A. | Effects of a decaffeinated green coffee extract on body weight control by regulation of glucose metabolism |
SG10201500552PA (en) | 2010-01-26 | 2015-03-30 | Eisai R&D Man Co Ltd | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
SG11201603490TA (en) | 2013-11-04 | 2016-05-30 | Eisai R&D Man Co Ltd | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
RU2676486C1 (ru) | 2013-12-06 | 2018-12-29 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Способы, предназначенные для синтеза аналогов галихондрина b |
CN117024469A (zh) | 2015-05-07 | 2023-11-10 | 卫材R&D管理有限公司 | 可用于合成软海绵素大环内酯的大环化反应以及中间体和其他片段 |
SG11201806133UA (en) | 2016-02-12 | 2018-08-30 | Eisai R&D Man Co Ltd | Intermediates in the synthesis of eribulin and related methods of synthesis |
SG11201811671XA (en) | 2016-06-30 | 2019-01-30 | Eisai R&D Man Co Ltd | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
IL275729B2 (en) | 2018-01-03 | 2023-09-01 | Eisai R&D Man Co Ltd | Prins reaction and compounds useful in the synthesis of helicondrin macrolides and their analogs |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60192555A (ja) * | 1984-03-13 | 1985-10-01 | Osaka Chem Lab | 抗アレルギ−食品 |
JPS60243016A (ja) * | 1984-05-17 | 1985-12-03 | Tsumura Juntendo Inc | 抗インフルエンザウイルス剤 |
EP0464859A1 (en) * | 1984-05-23 | 1992-01-08 | Green Cross Corporation | A lipoxygenase inhibitor |
DE3603576A1 (de) * | 1986-02-06 | 1987-08-13 | Code Kaffee Handel | Verwendung von gerbstoffen und/oder chlorogensaeure sowie nahrungs-, genuss- und/oder arzneimittel mit gerbstoff- und/oder chlorogensaeurezusatz |
-
1993
- 1993-09-03 TW TW082107191A patent/TW255880B/zh active
- 1993-09-06 AT AT93114260T patent/ATE181237T1/de not_active IP Right Cessation
- 1993-09-06 DK DK93114260T patent/DK0587087T3/da active
- 1993-09-06 DE DE59309649T patent/DE59309649D1/de not_active Expired - Fee Related
- 1993-09-06 ES ES93114260T patent/ES2135429T3/es not_active Expired - Lifetime
- 1993-09-06 EP EP93114260A patent/EP0587087B1/de not_active Expired - Lifetime
- 1993-09-07 US US08/116,564 patent/US5451573A/en not_active Expired - Fee Related
- 1993-09-07 PH PH46828A patent/PH30278A/en unknown
- 1993-09-07 FI FI933902A patent/FI933902A/fi unknown
- 1993-09-07 IL IL10693593A patent/IL106935A/xx not_active IP Right Cessation
- 1993-09-07 HU HU9302527A patent/HUT64843A/hu unknown
- 1993-09-08 CN CN93116663A patent/CN1042329C/zh not_active Expired - Fee Related
- 1993-09-08 PL PL93300328A patent/PL300328A1/xx unknown
- 1993-09-08 CA CA002105707A patent/CA2105707A1/en not_active Abandoned
- 1993-09-08 NO NO933201A patent/NO179671C/no not_active IP Right Cessation
- 1993-09-08 AU AU46170/93A patent/AU662836B2/en not_active Ceased
- 1993-09-08 RU RU93045145A patent/RU2131248C1/ru active
- 1993-09-08 ZA ZA936610A patent/ZA936610B/xx unknown
- 1993-09-08 JP JP5223056A patent/JPH06211737A/ja not_active Abandoned
- 1993-09-08 CZ CZ931867A patent/CZ284995B6/cs not_active IP Right Cessation
- 1993-09-09 KR KR1019930018066A patent/KR100299205B1/ko not_active IP Right Cessation
-
1998
- 1998-12-11 HK HK98113223A patent/HK1011934A1/xx unknown
-
1999
- 1999-08-11 GR GR990402034T patent/GR3030953T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE59309649D1 (de) | 1999-07-22 |
NO933201L (no) | 1994-03-10 |
AU662836B2 (en) | 1995-09-14 |
EP0587087A1 (de) | 1994-03-16 |
KR100299205B1 (ko) | 2001-11-22 |
CA2105707A1 (en) | 1994-03-10 |
PH30278A (en) | 1997-02-20 |
HUT64843A (en) | 1994-03-28 |
ZA936610B (en) | 1994-03-28 |
FI933902A0 (fi) | 1993-09-07 |
CN1042329C (zh) | 1999-03-03 |
GR3030953T3 (en) | 1999-11-30 |
CZ284995B6 (cs) | 1999-04-14 |
KR940006580A (ko) | 1994-04-25 |
HK1011934A1 (en) | 1999-07-23 |
TW255880B (es) | 1995-09-01 |
FI933902A (fi) | 1994-03-10 |
IL106935A0 (en) | 1993-12-28 |
HU9302527D0 (en) | 1993-11-29 |
DK0587087T3 (da) | 1999-12-06 |
CN1086806A (zh) | 1994-05-18 |
RU2131248C1 (ru) | 1999-06-10 |
PL300328A1 (en) | 1994-03-21 |
AU4617093A (en) | 1994-03-17 |
NO933201D0 (no) | 1993-09-08 |
ATE181237T1 (de) | 1999-07-15 |
CZ186793A3 (en) | 1994-03-16 |
NO179671C (no) | 1996-11-27 |
US5451573A (en) | 1995-09-19 |
EP0587087B1 (de) | 1999-06-16 |
IL106935A (en) | 1997-07-13 |
NO179671B (no) | 1996-08-19 |
JPH06211737A (ja) | 1994-08-02 |
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