HUP9700955A3 - Substituted 2-naphtoylguanidine derivatives, their production, and pharmaceutical compositions containing them - Google Patents

Substituted 2-naphtoylguanidine derivatives, their production, and pharmaceutical compositions containing them

Info

Publication number
HUP9700955A3
HUP9700955A3 HU9700955A HUP9700955A HUP9700955A3 HU P9700955 A3 HUP9700955 A3 HU P9700955A3 HU 9700955 A HU9700955 A HU 9700955A HU P9700955 A HUP9700955 A HU P9700955A HU P9700955 A3 HUP9700955 A3 HU P9700955A3
Authority
HU
Hungary
Prior art keywords
naphtoylguanidine
derivatives
substituted
production
pharmaceutical compositions
Prior art date
Application number
HU9700955A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HU9700955D0 publication Critical patent/HU9700955D0/hu
Publication of HUP9700955A2 publication Critical patent/HUP9700955A2/hu
Publication of HUP9700955A3 publication Critical patent/HUP9700955A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
HU9700955A 1996-05-29 1997-05-27 Substituted 2-naphtoylguanidine derivatives, their production, and pharmaceutical compositions containing them HUP9700955A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19621483A DE19621483A1 (de) 1996-05-29 1996-05-29 Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (3)

Publication Number Publication Date
HU9700955D0 HU9700955D0 (en) 1997-07-28
HUP9700955A2 HUP9700955A2 (hu) 1998-03-02
HUP9700955A3 true HUP9700955A3 (en) 1998-04-28

Family

ID=7795549

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700955A HUP9700955A3 (en) 1996-05-29 1997-05-27 Substituted 2-naphtoylguanidine derivatives, their production, and pharmaceutical compositions containing them

Country Status (29)

Country Link
US (1) US6087304A (hu)
EP (1) EP0810206B1 (hu)
JP (1) JP4039588B2 (hu)
KR (1) KR970074776A (hu)
CN (1) CN1167759A (hu)
AR (1) AR008373A1 (hu)
AT (1) ATE198320T1 (hu)
AU (1) AU710065B2 (hu)
BR (1) BR9703338A (hu)
CA (1) CA2206366C (hu)
CZ (1) CZ163097A3 (hu)
DE (2) DE19621483A1 (hu)
DK (1) DK0810206T3 (hu)
ES (1) ES2154002T3 (hu)
GR (1) GR3035126T3 (hu)
HR (1) HRP970292B1 (hu)
HU (1) HUP9700955A3 (hu)
ID (1) ID16989A (hu)
IL (1) IL120924A (hu)
NO (1) NO308527B1 (hu)
NZ (1) NZ314915A (hu)
PL (1) PL185754B1 (hu)
PT (1) PT810206E (hu)
RU (1) RU2190600C2 (hu)
SI (1) SI0810206T1 (hu)
SK (1) SK282020B6 (hu)
TR (1) TR199700428A2 (hu)
TW (1) TW416944B (hu)
ZA (1) ZA974665B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19621482A1 (de) 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
PE20040167A1 (es) * 2002-03-28 2004-05-26 Novartis Ag Amidas del acido sulfamico
BRPI0511778A (pt) * 2004-06-02 2008-01-15 Hoffmann La Roche derivados da naftalina úteis como ligantes do receptor 3 da histamina
TW200614995A (en) * 2004-11-10 2006-05-16 Nicholas Piramal India Ltd Tricyclic guanidine derivatives as sodium-proton exchange inhibitors
ES2710662T3 (es) * 2005-06-24 2019-04-26 Biotron Ltd Compuestos de acilguanidina con actividad antiviral
AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
EP2069302B1 (en) * 2006-09-15 2010-08-25 Pfizer Inc. Substituted pyridylmethyl bicyclocarboxyamide compounds
US20120041036A1 (en) * 2009-02-09 2012-02-16 Isao Kinoyama Substituted acylguanidine derivatives (as amended)
WO2010090304A1 (ja) * 2009-02-09 2010-08-12 アステラス製薬株式会社 アシルグアニジン誘導体
TW201116281A (en) * 2009-08-06 2011-05-16 Astellas Pharma Inc N atom containing ring acylguanidine derivatives
MX2013008827A (es) 2011-02-02 2014-02-10 Astellas Pharma Inc Derivado de tetrahidroisoquinolina.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251545A (en) * 1979-09-19 1981-02-17 Gaf Corporation Fungicidal process using 1-(alkoxyaroyl)guanidines
IT1238227B (it) * 1989-12-01 1993-07-12 Modulo di smistamento per impianti di convogliamento a nastro e simili
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4415873A1 (de) * 1994-05-05 1995-11-09 Hoechst Ag Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
JPH08225513A (ja) * 1994-12-21 1996-09-03 Kanebo Ltd ナフトイルグアニジン誘導体
DE19621482A1 (de) * 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
IL120924A (en) 2002-03-10
PT810206E (pt) 2001-06-29
AR008373A1 (es) 2000-01-19
NO972433D0 (no) 1997-05-28
GR3035126T3 (en) 2001-03-30
SK67097A3 (en) 1997-12-10
EP0810206A1 (de) 1997-12-03
CZ163097A3 (cs) 1998-06-17
SI0810206T1 (en) 2001-04-30
ATE198320T1 (de) 2001-01-15
IL120924A0 (en) 1997-09-30
KR970074776A (ko) 1997-12-10
HRP970292B1 (en) 2001-08-31
DE19621483A1 (de) 1997-12-04
AU710065B2 (en) 1999-09-16
EP0810206B1 (de) 2000-12-27
BR9703338A (pt) 1998-08-18
US6087304A (en) 2000-07-11
JP4039588B2 (ja) 2008-01-30
DK0810206T3 (da) 2001-02-26
HRP970292A2 (en) 1998-04-30
DE59702802D1 (de) 2001-02-01
ZA974665B (en) 1997-12-01
CA2206366C (en) 2008-02-19
SK282020B6 (sk) 2001-10-08
MX9703922A (es) 1997-11-29
NO308527B1 (no) 2000-09-25
ES2154002T3 (es) 2001-03-16
PL318723A1 (en) 1997-12-08
PL185754B1 (pl) 2003-07-31
CN1167759A (zh) 1997-12-17
NZ314915A (en) 1998-02-26
AU2364597A (en) 1997-12-04
NO972433L (no) 1997-12-01
JPH1081664A (ja) 1998-03-31
TW416944B (en) 2001-01-01
RU2190600C2 (ru) 2002-10-10
HU9700955D0 (en) 1997-07-28
TR199700428A2 (xx) 1997-12-21
CA2206366A1 (en) 1997-11-29
ID16989A (id) 1997-11-27
HUP9700955A2 (hu) 1998-03-02

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