ES2166487T3 - Benzoil-guanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents
Benzoil-guanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.Info
- Publication number
- ES2166487T3 ES2166487T3 ES97108258T ES97108258T ES2166487T3 ES 2166487 T3 ES2166487 T3 ES 2166487T3 ES 97108258 T ES97108258 T ES 97108258T ES 97108258 T ES97108258 T ES 97108258T ES 2166487 T3 ES2166487 T3 ES 2166487T3
- Authority
- ES
- Spain
- Prior art keywords
- medicinal
- well
- guanidinas
- benzoil
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
Abstract
LA INVENCION TRATA DE BENZOILGUANIDINAS ORTO INDICADOS EN LAS REIVINDICACIONES, Y QUE, COMO MEDICAMENTOS ANTIARRITMICOS CON COMPONENTE CARDIOPROTECTOR, SON IDONEAS PARA LA PROFILAXIS DEL INFARTO Y EL TRATAMIENTO DEL MISMO, ASI COMO PARA EL TRATAMIENTO DE LA ANGINA DE PECHO. TAMBIEN INHIBEN DE FORMA PREVENTIVA LOS PROCESOS PATOFISIOLOGICOS EN CASO DE QUE EXISTIERAN DAÑOS INDUCIDOS ISQUEMICAMENTE, EN PARTICULAR SI SE PRODUJERAN ARRITMIAS CARDIACAS INDUCIDAS ISQUEMICAMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19622370A DE19622370A1 (de) | 1996-06-04 | 1996-06-04 | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2166487T3 true ES2166487T3 (es) | 2002-04-16 |
Family
ID=7796095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97108258T Expired - Lifetime ES2166487T3 (es) | 1996-06-04 | 1997-05-22 | Benzoil-guanidinas sustituidas en posicion orto, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. |
Country Status (29)
Country | Link |
---|---|
US (1) | US6011063A (es) |
EP (1) | EP0811610B1 (es) |
JP (1) | JP4101904B2 (es) |
KR (1) | KR980002019A (es) |
CN (1) | CN1064956C (es) |
AR (1) | AR008761A1 (es) |
AT (1) | ATE209630T1 (es) |
AU (1) | AU723665B2 (es) |
BR (1) | BR9703440A (es) |
CA (1) | CA2206758C (es) |
CZ (1) | CZ289411B6 (es) |
DE (2) | DE19622370A1 (es) |
DK (1) | DK0811610T3 (es) |
ES (1) | ES2166487T3 (es) |
HR (1) | HRP970304B1 (es) |
HU (1) | HUP9700989A3 (es) |
ID (1) | ID17038A (es) |
IL (1) | IL120988A0 (es) |
MX (1) | MX9704094A (es) |
NO (1) | NO310188B1 (es) |
NZ (1) | NZ314973A (es) |
PL (1) | PL185757B1 (es) |
PT (1) | PT811610E (es) |
RU (1) | RU2214397C2 (es) |
SI (1) | SI0811610T1 (es) |
SK (1) | SK282628B6 (es) |
TR (1) | TR199700453A2 (es) |
TW (1) | TW429243B (es) |
ZA (1) | ZA974869B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410563B1 (en) | 1999-12-22 | 2002-06-25 | Merck Frosst Canada & Co. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
MY123585A (en) | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
US6639077B2 (en) | 2000-03-23 | 2003-10-28 | Merck Frosst Canada & Co. | Tri-aryl-substituted-ethane PDE4 inhibitors |
AU6196201A (en) | 2000-05-25 | 2001-12-03 | Merck Frosst Canada Inc | Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor |
US6740666B2 (en) | 2000-12-20 | 2004-05-25 | Merck & Co., Inc. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
EP1397359B1 (en) | 2001-05-24 | 2005-08-31 | Merck Frosst Canada & Co. | 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors |
JO2311B1 (en) | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
AU2003213783B2 (en) | 2002-03-12 | 2007-01-25 | Merck Sharp & Dohme Corp. | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 |
GB0916163D0 (en) * | 2009-09-15 | 2009-10-28 | Shire Llc | Prodrugs of guanfacine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0612723T3 (da) * | 1993-02-20 | 1998-03-30 | Hoechst Ag | Substituerede benzoylguanidiner, fremgangsmåde til fremstilling, deres anvendelse som lægemiddel, som inhibitor af den cellulære Na+/H+-udbytning eller som diagnostikum samt lægemiddel med indhold deraf |
DE4318756A1 (de) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4422685A1 (de) * | 1994-06-29 | 1996-01-04 | Hoechst Ag | Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1996
- 1996-06-04 DE DE19622370A patent/DE19622370A1/de not_active Withdrawn
-
1997
- 1997-05-22 SI SI9730284T patent/SI0811610T1/xx unknown
- 1997-05-22 EP EP97108258A patent/EP0811610B1/de not_active Expired - Lifetime
- 1997-05-22 DK DK97108258T patent/DK0811610T3/da active
- 1997-05-22 ES ES97108258T patent/ES2166487T3/es not_active Expired - Lifetime
- 1997-05-22 AT AT97108258T patent/ATE209630T1/de not_active IP Right Cessation
- 1997-05-22 DE DE59705495T patent/DE59705495D1/de not_active Expired - Lifetime
- 1997-05-22 PT PT97108258T patent/PT811610E/pt unknown
- 1997-05-30 NZ NZ314973A patent/NZ314973A/en unknown
- 1997-06-02 TR TR97/00453A patent/TR199700453A2/xx unknown
- 1997-06-02 ID IDP971869A patent/ID17038A/id unknown
- 1997-06-02 CZ CZ19971696A patent/CZ289411B6/cs not_active IP Right Cessation
- 1997-06-02 TW TW086107502A patent/TW429243B/zh active
- 1997-06-02 SK SK696-97A patent/SK282628B6/sk unknown
- 1997-06-02 CN CN971054797A patent/CN1064956C/zh not_active Expired - Fee Related
- 1997-06-02 AR ARP970102385A patent/AR008761A1/es unknown
- 1997-06-02 AU AU24650/97A patent/AU723665B2/en not_active Ceased
- 1997-06-03 RU RU97109913/04A patent/RU2214397C2/ru not_active IP Right Cessation
- 1997-06-03 US US08/868,077 patent/US6011063A/en not_active Expired - Lifetime
- 1997-06-03 HR HR970304A patent/HRP970304B1/xx not_active IP Right Cessation
- 1997-06-03 NO NO19972527A patent/NO310188B1/no not_active IP Right Cessation
- 1997-06-03 HU HU9700989A patent/HUP9700989A3/hu unknown
- 1997-06-03 ZA ZA9704869A patent/ZA974869B/xx unknown
- 1997-06-03 JP JP14439397A patent/JP4101904B2/ja not_active Expired - Fee Related
- 1997-06-03 PL PL97320327A patent/PL185757B1/pl not_active IP Right Cessation
- 1997-06-03 MX MX9704094A patent/MX9704094A/es unknown
- 1997-06-03 IL IL12098897A patent/IL120988A0/xx unknown
- 1997-06-03 KR KR1019970022785A patent/KR980002019A/ko not_active Application Discontinuation
- 1997-06-04 BR BR9703440A patent/BR9703440A/pt not_active IP Right Cessation
- 1997-06-04 CA CA002206758A patent/CA2206758C/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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