ES2062120T3 - Nuevas n-(aril substituido)-n'-(alcoxi substituido)-ureas y tioureas como agentes anticolesterolemicos y antiateroscleroticos. - Google Patents

Nuevas n-(aril substituido)-n'-(alcoxi substituido)-ureas y tioureas como agentes anticolesterolemicos y antiateroscleroticos.

Info

Publication number
ES2062120T3
ES2062120T3 ES90102510T ES90102510T ES2062120T3 ES 2062120 T3 ES2062120 T3 ES 2062120T3 ES 90102510 T ES90102510 T ES 90102510T ES 90102510 T ES90102510 T ES 90102510T ES 2062120 T3 ES2062120 T3 ES 2062120T3
Authority
ES
Spain
Prior art keywords
substituted
new
anticolesterolemic
antiaterosclerotic
thioureas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90102510T
Other languages
English (en)
Inventor
Bharat Kalidas Trivedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/308,911 external-priority patent/US4923896A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2062120T3 publication Critical patent/ES2062120T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/22—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Abstract

SON DESCRITOS NUEVA UREA-(ALCOXI SUSTITUIDO)-N''-(ARIL SUSTITUIDO)-N Y DERIVADOS TIOUREA, COMO TAMBIEN METODOS PARA LAPREPARACION Y COMPOSICIONES FARMACEUTICAS DEL MISMO, QUE SON UTILES EN PREVENIR LA ABSORCION INTESTINAL DE COLESTEROL Y ASI SON UTILES EN EL TRATAMIENTO DE HIPERCOLESTEROLEMIA Y ARTEROESCLEROSIS.
ES90102510T 1989-02-09 1990-02-08 Nuevas n-(aril substituido)-n'-(alcoxi substituido)-ureas y tioureas como agentes anticolesterolemicos y antiateroscleroticos. Expired - Lifetime ES2062120T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/308,911 US4923896A (en) 1989-02-09 1989-02-09 N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
US07/462,563 US5155127A (en) 1989-02-09 1990-01-18 N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents

Publications (1)

Publication Number Publication Date
ES2062120T3 true ES2062120T3 (es) 1994-12-16

Family

ID=26976513

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90102510T Expired - Lifetime ES2062120T3 (es) 1989-02-09 1990-02-08 Nuevas n-(aril substituido)-n'-(alcoxi substituido)-ureas y tioureas como agentes anticolesterolemicos y antiateroscleroticos.

Country Status (14)

Country Link
US (1) US5155127A (es)
EP (1) EP0386487B1 (es)
JP (1) JP3003941B2 (es)
KR (1) KR900012896A (es)
AT (1) ATE100443T1 (es)
AU (1) AU620966B2 (es)
CA (1) CA2009669C (es)
DE (1) DE69006048T2 (es)
DK (1) DK0386487T3 (es)
ES (1) ES2062120T3 (es)
IE (1) IE63412B1 (es)
NO (1) NO900585L (es)
NZ (1) NZ232410A (es)
PT (1) PT93088A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310748A (en) * 1992-05-11 1994-05-10 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
US5364875A (en) * 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5326787A (en) * 1992-05-12 1994-07-05 Abbott Laboratories Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory activity
EP0642498A1 (en) * 1992-05-28 1995-03-15 Pfizer Inc. NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT)
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
PT1263421E (pt) 2000-02-02 2005-08-31 Warner Lambert Co Avasimibe, o inibidor duplo da sintese de ester de colesterilo e de ester ceroso, para o tratamento de disturbios da glandula sebacea
WO2009073620A2 (en) * 2007-11-30 2009-06-11 Newlink Genetics Ido inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112342A (en) * 1960-10-03 1963-11-26 Du Pont 1-methoxy-1-methyl-3-(3-chloro-4-cumenyl) urea
US4387106A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
DE3737195A1 (de) * 1987-11-03 1989-05-18 Bayer Ag Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
US4868210A (en) * 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions

Also Published As

Publication number Publication date
IE63412B1 (en) 1995-04-19
PT93088A (pt) 1990-08-31
KR900012896A (ko) 1990-09-03
CA2009669A1 (en) 1990-08-09
IE900457L (en) 1990-08-09
AU620966B2 (en) 1992-02-27
JP3003941B2 (ja) 2000-01-31
EP0386487A1 (en) 1990-09-12
NO900585L (no) 1990-08-10
CA2009669C (en) 2001-05-15
EP0386487B1 (en) 1994-01-19
DE69006048D1 (de) 1994-03-03
NO900585D0 (no) 1990-02-07
US5155127A (en) 1992-10-13
NZ232410A (en) 1991-03-26
AU4919990A (en) 1990-08-16
DE69006048T2 (de) 1994-05-05
DK0386487T3 (da) 1994-02-28
JPH02275848A (ja) 1990-11-09
ATE100443T1 (de) 1994-02-15

Similar Documents

Publication Publication Date Title
DE69027865T2 (de) ZUSAMMENSETZUNGEN enthaltend omega Conotoxin Peptide Derivate und deren Verwendung ZUR BEHANDLUNG VON ISCHÄMIE-ARTIGEN NEURONALEN SCHÄDIGUNGEN
ES2161291T3 (es) N-(indol-2-carbonil)amidas y derivados como inhibidores de la glucogeno fosforilasa.
ES2072323T3 (es) Compuestos de piperidina y su preparacion y empleo.
BR0209271A (pt) Composto, uso de um composto composição farmacêutica, formulação em aerossol farmacêutica, método para o tratamento de um paciente humano ou animal com uma condição inflamatória e/ou alérgica, e, processo para a preparação de um composto
ES2170141T3 (es) 4-aminoderivados del acido micofenolico con actividad inmunosupresora.
AR005703A1 (es) Oxazolidinonas sustituidas, procedimiento para su preparacion, uso de las mismas para preparar medicamentos y medicamentos que las contienen
DE69627035T2 (de) Derivate von aminosäuren, sie enthaltende pharmazeutische zusammensetzungen sowie deren herstellunsgverfahren
DE68913762T2 (de) Diarylverbindungen als antiatherosklerotische Mittel.
ES2062120T3 (es) Nuevas n-(aril substituido)-n'-(alcoxi substituido)-ureas y tioureas como agentes anticolesterolemicos y antiateroscleroticos.
MX24839A (es) 3-arilcarbonil-1-aminoalquilo-1h-indoles, proceso para su preparacion y composicion farmaceutica quelos contiene.
ATE78397T1 (de) Verwendung von p-chlorophenoxyazetat von n,ndimethylbiguanidzur behandlung von neuropathien und nervendegeneration.
PT99435A (pt) Processo para a preparacao de derivados de amino-sulfonil-ureia e de composicoes farmaceuticas que os contem
BRPI9509819B8 (pt) benzamida enterocinética e composição farmacêutica compreendendo a mesma
ES2144154T3 (es) Derivados de eritromicina a 9-0-oxima dotados de actividad antibiotica.
RU94040886A (ru) Применение производных мелатонина для лечения нарушений сна, фармацевтическая композиция
DE3767308D1 (de) Verwendung von sulfonamidderivaten zur herstellung eines antivirusmittels.
BR9916043A (pt) Composto, uso do mesmo e de seus saisfarmaceuticamente aceitáveis, e, composiçãofarmacêutica para tratamento de infecções deherpes viral em pacientes
DE68929321D1 (de) Therapeutische Anwendungen von 2',5'-Oligoadenylat-Derivaten
ATE55985T1 (de) 4-benzyloxy-3-pyrrolin-2-on-1-yl-acetamid, dessen herstellung und verwendung.
PT84130B (pt) Processo para a preparacao de novos derivados de 3-alcoxiflavonas e das respectivas composicoes farmaceuticas
NO903281D0 (no) S-substituerte beta-tioakrylamider og anvendelse derav som mikrobiocider.
NO921525L (no) L-alfa-glyserofosforyl-d-myo-inositol for behandling av perifere nervelidelser og hjernelidelser
ATE106874T1 (de) Kynurensäurederivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ES2162022T3 (es) Derivados de tiol con actividad inhibidora de la metalopeptidasa.
BR9813037A (pt) Composto, processo para sua preparação, uso do mesmo, preparação farmacêutica, e, combinação desta com pelo menos uma outra substância ativa

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 386487

Country of ref document: ES