DE69006048D1 - N-(substituierte aryl)-N'-(substituierte alkoxy)-Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel. - Google Patents

N-(substituierte aryl)-N'-(substituierte alkoxy)-Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel.

Info

Publication number
DE69006048D1
DE69006048D1 DE90102510T DE69006048T DE69006048D1 DE 69006048 D1 DE69006048 D1 DE 69006048D1 DE 90102510 T DE90102510 T DE 90102510T DE 69006048 T DE69006048 T DE 69006048T DE 69006048 D1 DE69006048 D1 DE 69006048D1
Authority
DE
Germany
Prior art keywords
substituted
antihypercholesterolemic
ureas
substituted aryl
antiatherosclerotic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90102510T
Other languages
English (en)
Other versions
DE69006048T2 (de
Inventor
Bharat Kalidas Trivedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/308,911 external-priority patent/US4923896A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE69006048D1 publication Critical patent/DE69006048D1/de
Application granted granted Critical
Publication of DE69006048T2 publication Critical patent/DE69006048T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/22—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Detergent Compositions (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE90102510T 1989-02-09 1990-02-08 N-(substituierte aryl)-N'-(substituierte alkoxy)-Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel. Expired - Fee Related DE69006048T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/308,911 US4923896A (en) 1989-02-09 1989-02-09 N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
US07/462,563 US5155127A (en) 1989-02-09 1990-01-18 N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents

Publications (2)

Publication Number Publication Date
DE69006048D1 true DE69006048D1 (de) 1994-03-03
DE69006048T2 DE69006048T2 (de) 1994-05-05

Family

ID=26976513

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90102510T Expired - Fee Related DE69006048T2 (de) 1989-02-09 1990-02-08 N-(substituierte aryl)-N'-(substituierte alkoxy)-Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel.

Country Status (14)

Country Link
US (1) US5155127A (de)
EP (1) EP0386487B1 (de)
JP (1) JP3003941B2 (de)
KR (1) KR900012896A (de)
AT (1) ATE100443T1 (de)
AU (1) AU620966B2 (de)
CA (1) CA2009669C (de)
DE (1) DE69006048T2 (de)
DK (1) DK0386487T3 (de)
ES (1) ES2062120T3 (de)
IE (1) IE63412B1 (de)
NO (1) NO900585L (de)
NZ (1) NZ232410A (de)
PT (1) PT93088A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364875A (en) * 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5310748A (en) * 1992-05-11 1994-05-10 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
US5326787A (en) * 1992-05-12 1994-07-05 Abbott Laboratories Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory activity
US6001860A (en) * 1992-05-28 1999-12-14 Pfizer Inc. N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT)
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
NZ520330A (en) * 2000-02-02 2004-02-27 Warner Lambert Co [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6- diisopropyl-phenyl ester, dual inhibitors of cholesterol ester and wax ester synthesis for sebaceous gland disorders
US10047066B2 (en) * 2007-11-30 2018-08-14 Newlink Genetics Corporation IDO inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112342A (en) * 1960-10-03 1963-11-26 Du Pont 1-methoxy-1-methyl-3-(3-chloro-4-cumenyl) urea
US4387106A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
DE3737195A1 (de) * 1987-11-03 1989-05-18 Bayer Ag Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4868210A (en) * 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents

Also Published As

Publication number Publication date
EP0386487B1 (de) 1994-01-19
NZ232410A (en) 1991-03-26
PT93088A (pt) 1990-08-31
ATE100443T1 (de) 1994-02-15
IE63412B1 (en) 1995-04-19
JPH02275848A (ja) 1990-11-09
NO900585L (no) 1990-08-10
CA2009669C (en) 2001-05-15
EP0386487A1 (de) 1990-09-12
DK0386487T3 (da) 1994-02-28
CA2009669A1 (en) 1990-08-09
US5155127A (en) 1992-10-13
JP3003941B2 (ja) 2000-01-31
IE900457L (en) 1990-08-09
NO900585D0 (no) 1990-02-07
ES2062120T3 (es) 1994-12-16
AU620966B2 (en) 1992-02-27
KR900012896A (ko) 1990-09-03
AU4919990A (en) 1990-08-16
DE69006048T2 (de) 1994-05-05

Similar Documents

Publication Publication Date Title
ATE98223T1 (de) N-(((2,6-disubstituierte)phenyl>n'- arylalkyl> harnstoffe als antihypercholesterolemische und antiatherosclerotische mittel.
DE68907359D1 (de) N-(((2,6-disubstituierte)phenyl)-n'-diarylalkyl) harnstoffe als antihyperlipidemische und antiatherosclerotische mittel.
PT84737B (pt) Processo para a preparacao de derivados de n-(2'-aminofenil)-benzamida e de composicoes farmaceuticas contendo-os
ATE110713T1 (de) Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen.
ATE90340T1 (de) Antihyperlipidemische und antiatherosclerotische verbindungen und zusammensetzungen.
ATE104271T1 (de) 2-(2-hydroxy-3phenoxypropylamino)ethylphenoxyacetamide, verfahren und zwischenprodukte zu deren herstellung.
YU13396A (sh) N-(3-benzofuranil) urea derivati, postupci za njihovo dobijanje, kompozicije koje ih sadrže i njihova upotreba u lekovima
DE3774858D1 (de) Derivate von n-(2-alkyl-3-mercaptoglutaryl)-alpha-aminosaeuren und deren verwendung als collagenase-inhibitoren.
NO178768C (no) 11-aryl-4-östrener og antikonsepsjonsmidler inneholdende disse
DE69006048D1 (de) N-(substituierte aryl)-N'-(substituierte alkoxy)-Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel.
ES2037768T3 (es) Procedimiento para preparar n-(fenil(2,6-disustituido))-ureas y carbamatos inhibidores de acil-coa: colesterol acil-transferasa.
DE68913762D1 (de) Diarylverbindungen als antiatherosklerotische Mittel.
ATE107628T1 (de) Hydrophile derivate von benzylidenkampfer enthaltende kosmetische und pharmazeutische zusammensetzungen und sulfonierte hydrophile derivate von benzylidenkampfer.
PT87680A (pt) A process for the preparation of n-(aryl-,arylthio-arylsulfinyl-and arylsulfonyl-n,n'-(or n'n')alkylamino-alkyl ureas and cyanoguanidines and of pharmaceutical compositions containing the same
DE60220055D1 (de) 4-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)harnstoff und dessen verwendung bei der behandlung von mit glycogensynthasekinase-3 (gsk3) assoziierten leiden
DE69021724D1 (de) Modifizierte Protease, Verfahren zu deren Herstellung und diese enthaltende kosmetische Zusammensetzungen.
DK0556322T3 (da) Aminosulfonylurinstof-ACAT-inhibitorer
AR002384A1 (es) Método para preparar ureas cíclicas asimétricas n-sustituidas y n,n' disustituidas
DE69837334D1 (de) Heterozyclische verbindungen, ihr herstellungsverfahren und diese enthaltende pharmazeutische zusammensetzungen
DK419987D0 (da) Insecticider indeholdende nitromethylen-derivater
PT74931A (en) Process for preparing n-(aryloxyalkyl)-n'-(aminoalkyl) ureas and of pharmaceutical compositions containing the same
BR9403572A (pt) Composto, processo para sua preparação e formulação farmacêutica
ATE111461T1 (de) N-((2-thenoylmerkapto-3-methyl)-butanoyl>- homocysteinthiolacton, verfahren zu seiner herstellung und diese enthaltende pharmaceutische zusammensetzungen.
ATE69810T1 (de) Derivate von n-(2-alkyl-3-mercaptoglutaryl)-alpha-aminosaeure und deren verwendung als collagenaseinhibitoren.
FR2641279B1 (fr) Derives de n-(amino-2 ethyl) n-(((methylthio-2 phenyl) (phenylmethyl)amino)-2 oxo ethyl)amides et carbamates, leur preparation et leur application en therapeutique

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee