NO980144L - Nye heterocykliske forbindelser for behandling av smerte og anvendelse derav - Google Patents
Nye heterocykliske forbindelser for behandling av smerte og anvendelse deravInfo
- Publication number
- NO980144L NO980144L NO980144A NO980144A NO980144L NO 980144 L NO980144 L NO 980144L NO 980144 A NO980144 A NO 980144A NO 980144 A NO980144 A NO 980144A NO 980144 L NO980144 L NO 980144L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- pain
- treatment
- independently
- compounds
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 102000003840 Opioid Receptors Human genes 0.000 abstract 1
- 108090000137 Opioid Receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/08—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/16—Eight-membered rings
- C07D313/20—Eight-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/16—Eight-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Polycykliske alkaloider med formel formel l hvor R, er H, C,^ alkyl eller C^2 aryl eventuelt substituert med polare grupper; R2 og R3 er uavhengig H, OH, C^ alkyl, -C(NH)-NH2, en positivt ladet gruppe eller C7.13 aralkyl eventuelt substituert med NH2, OH, C^ alkyl eller halogen; eller R2 og Rjtilsammen danner en 5 til 6-leddet ring eventuelt inneholdende et heteroatom; R4er H, CM alkyl, OR8l SR6 eller N(R6)2, hvor hver R6 er uavhengig H, CM alkyl eller halogen; X er O, S, SO, SO2, N-R5 eller C-(R5)2, hvor hver R5 er uavhengig H, C,.. alkyl eller C7.13 aralkyl eventuelt avbrutt med ett eller flere heteroatomer; n er et helt tall fra O til 2; m er et helt tall fra O til 3; med det forbehold at når X er CH2, da er R, ikke CH3, R2 og R3 er ikke begge H, R4 er ikke OH. m er ikke 3 og n er ikke 0. for behandling av smerte og farmasøytisk godtagbare preparater omfattende slike forbindelser. Forbindelsene ifølge foreliggende oppfinnelse virker som agonister på opiat-reseptoren.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9514417.6A GB9514417D0 (en) | 1995-07-14 | 1995-07-14 | Novel heterocyclic compounds for the treatment of pain and use thereof |
| PCT/CA1996/000467 WO1997003978A1 (en) | 1995-07-14 | 1996-07-12 | Novel heterocyclic compounds for the treatment of pain and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO980144D0 NO980144D0 (no) | 1998-01-13 |
| NO980144L true NO980144L (no) | 1998-01-13 |
Family
ID=10777657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO980144A NO980144L (no) | 1995-07-14 | 1998-01-13 | Nye heterocykliske forbindelser for behandling av smerte og anvendelse derav |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6054474A (no) |
| EP (1) | EP0850234B1 (no) |
| JP (1) | JPH11509211A (no) |
| CN (1) | CN1196053A (no) |
| AT (1) | ATE209643T1 (no) |
| AU (1) | AU708504B2 (no) |
| BR (1) | BR9609548A (no) |
| CA (1) | CA2223646A1 (no) |
| DE (1) | DE69617444T2 (no) |
| EA (1) | EA001185B1 (no) |
| ES (1) | ES2167577T3 (no) |
| FI (1) | FI974609A (no) |
| GB (1) | GB9514417D0 (no) |
| HU (1) | HUP9900350A3 (no) |
| NO (1) | NO980144L (no) |
| NZ (1) | NZ311612A (no) |
| WO (1) | WO1997003978A1 (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10153345A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen |
| US6881829B2 (en) * | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
| CN108210933B (zh) * | 2016-12-22 | 2021-05-04 | 北京键凯科技股份有限公司 | 一种地佐辛与聚乙二醇的结合物 |
| US20220117913A1 (en) * | 2019-02-02 | 2022-04-21 | Yangtze River Pharmaceutical Group Co., Ltd. | Dezocine derivative and medical use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3836670A (en) * | 1971-11-19 | 1974-09-17 | American Home Prod | Benzobicycloalkane amines for inducing analgesia |
| US5214156A (en) * | 1988-03-25 | 1993-05-25 | The Upjohn Company | Therapeutically useful tetralin derivatives |
| IL93464A (en) * | 1989-02-27 | 1996-10-16 | Lilly Co Eli | 2-Amino-1,2,3,4-Tetrahydronaplanin and 3 aminochromes with a transformed ring, a process for their preparation and pharmaceutical preparations containing them |
-
1995
- 1995-07-14 GB GBGB9514417.6A patent/GB9514417D0/en active Pending
-
1996
- 1996-07-12 ES ES96921855T patent/ES2167577T3/es not_active Expired - Lifetime
- 1996-07-12 EA EA199800062A patent/EA001185B1/ru not_active IP Right Cessation
- 1996-07-12 DE DE69617444T patent/DE69617444T2/de not_active Expired - Fee Related
- 1996-07-12 AU AU62968/96A patent/AU708504B2/en not_active Ceased
- 1996-07-12 EP EP96921855A patent/EP0850234B1/en not_active Expired - Lifetime
- 1996-07-12 NZ NZ311612A patent/NZ311612A/xx unknown
- 1996-07-12 HU HU9900350A patent/HUP9900350A3/hu unknown
- 1996-07-12 WO PCT/CA1996/000467 patent/WO1997003978A1/en active IP Right Grant
- 1996-07-12 CA CA002223646A patent/CA2223646A1/en not_active Abandoned
- 1996-07-12 AT AT96921855T patent/ATE209643T1/de not_active IP Right Cessation
- 1996-07-12 JP JP9506109A patent/JPH11509211A/ja active Pending
- 1996-07-12 US US08/981,932 patent/US6054474A/en not_active Expired - Fee Related
- 1996-07-12 BR BR9609548A patent/BR9609548A/pt unknown
- 1996-07-12 CN CN96196893A patent/CN1196053A/zh active Pending
-
1997
- 1997-12-23 FI FI974609A patent/FI974609A/fi unknown
-
1998
- 1998-01-13 NO NO980144A patent/NO980144L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9514417D0 (en) | 1995-09-13 |
| ATE209643T1 (de) | 2001-12-15 |
| CN1196053A (zh) | 1998-10-14 |
| BR9609548A (pt) | 1999-03-02 |
| NZ311612A (en) | 1999-05-28 |
| HUP9900350A3 (en) | 1999-11-29 |
| EA001185B1 (ru) | 2000-12-25 |
| DE69617444T2 (de) | 2002-08-01 |
| HUP9900350A2 (hu) | 1999-06-28 |
| AU6296896A (en) | 1997-02-18 |
| WO1997003978A1 (en) | 1997-02-06 |
| EP0850234A1 (en) | 1998-07-01 |
| CA2223646A1 (en) | 1997-02-06 |
| DE69617444D1 (de) | 2002-01-10 |
| NO980144D0 (no) | 1998-01-13 |
| JPH11509211A (ja) | 1999-08-17 |
| US6054474A (en) | 2000-04-25 |
| FI974609A (fi) | 1998-01-14 |
| ES2167577T3 (es) | 2002-05-16 |
| EA199800062A1 (ru) | 1998-08-27 |
| AU708504B2 (en) | 1999-08-05 |
| FI974609A0 (fi) | 1997-12-23 |
| EP0850234B1 (en) | 2001-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |