UA41869C2 - Похідні етаноламіну, спосіб їх одержання, фармацевтична композиція, спосіб лікування - Google Patents
Похідні етаноламіну, спосіб їх одержання, фармацевтична композиція, спосіб лікуванняInfo
- Publication number
- UA41869C2 UA41869C2 UA93003971A UA93003971A UA41869C2 UA 41869 C2 UA41869 C2 UA 41869C2 UA 93003971 A UA93003971 A UA 93003971A UA 93003971 A UA93003971 A UA 93003971A UA 41869 C2 UA41869 C2 UA 41869C2
- Authority
- UA
- Ukraine
- Prior art keywords
- optionally substituted
- group
- ethanolamine
- derivatives
- atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/14—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to hydrocarbon groups substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Цей винахід відноситься до нових похідних етаноламіну і їх фармакологічно прийнятних солей, які можуть бути використані як ліки. Похідні етаноламіну загальної формули (I): де R1 - фенил, нафтил, інданіл, піриділ, бензофуразаніл або бензодіоксоліл, кожний з яких може містити такі заступники, як атом галогену або гідрокси R2 - атом галогену, нітрогрупа, оксигрупа, нижча алкінільна група, необов'язково заміщена ацильною групою, нижча алкенільна група, необов'язково заміщена ацильною групою, нижча алкоксигрупа, необов'язково заміщена ацильною групою, або аміногрупа, необов'язково заміщена ацил(нижчою) алкільною групою R3 - атом водню, бензил або нижча алкільна група, необов'язково заміщена нижчою алкілтіогрупою n - ціле число від 0 до 3, а жирна лінія означає простий зв'язок або подвійний зв'язок.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929202236A GB9202236D0 (en) | 1992-02-03 | 1992-02-03 | New ethanolamine derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same |
GB929217991A GB9217991D0 (en) | 1992-08-24 | 1992-08-24 | New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
PCT/JP1993/000113 WO1993015041A1 (en) | 1992-02-03 | 1993-02-01 | Ethanolamine derivatives having sympathomimetic and anti-pollakiuria activities |
Publications (1)
Publication Number | Publication Date |
---|---|
UA41869C2 true UA41869C2 (uk) | 2001-10-15 |
Family
ID=26300256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA93003971A UA41869C2 (uk) | 1992-02-03 | 1993-02-01 | Похідні етаноламіну, спосіб їх одержання, фармацевтична композиція, спосіб лікування |
Country Status (19)
Country | Link |
---|---|
US (1) | US5387710A (uk) |
EP (1) | EP0583485B1 (uk) |
JP (2) | JP2819435B2 (uk) |
KR (1) | KR100250922B1 (uk) |
CN (1) | CN1063430C (uk) |
AT (1) | ATE156804T1 (uk) |
AU (1) | AU666162B2 (uk) |
CA (1) | CA2107566A1 (uk) |
DE (1) | DE69313051T2 (uk) |
DK (1) | DK0583485T3 (uk) |
ES (1) | ES2105286T3 (uk) |
GR (1) | GR3025106T3 (uk) |
HK (1) | HK1000768A1 (uk) |
HU (1) | HU218941B (uk) |
IL (1) | IL104567A (uk) |
MX (1) | MX9300552A (uk) |
TW (1) | TW225513B (uk) |
UA (1) | UA41869C2 (uk) |
WO (1) | WO1993015041A1 (uk) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2142453C1 (ru) * | 1995-04-15 | 1999-12-10 | Дайниппон Фармасьютикал Ко., Лтд. | ПРОИЗВОДНЫЕ 1-[ω-(3,4-ДИГИДРО-2-НАФТАЛИНИЛ)АЛКИЛ]ЦИКЛИЧЕСКОГО АМИНА И СОДЕРЖАЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ |
SG72727A1 (en) * | 1996-02-19 | 2000-05-23 | Kissei Pharmaceutical | 3,4-Disubstituted phenylethanolaminotetralincarboxamide derivatives |
EP0958835A4 (en) | 1996-08-19 | 2001-04-18 | Kissei Pharmaceutical | THERAPEUTIC OR PREVENTIVE REMEDY AGAINST INCONTINENCE OR FREQUENT URINARY ELIMINATION |
AUPO565997A0 (en) * | 1997-03-17 | 1997-04-10 | Fujisawa Pharmaceutical Co., Ltd. | Propanolamine derivatives |
GB9913083D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
WO2003035600A1 (fr) * | 2001-10-19 | 2003-05-01 | Fujisawa Pharmaceutical Co., Ltd. | Procede de production de derive de benzocycloheptene |
US20060100195A1 (en) * | 2001-11-19 | 2006-05-11 | Takayuki Maruyama | Remedies for urinary frequency |
MXPA04008918A (es) * | 2002-03-14 | 2004-11-26 | Fujisawa Pharmaceutical Co | Derivados de aminoalcohol como agonistas del receptor adrenergico beta-3. |
ZA200503510B (en) | 2002-11-07 | 2006-12-27 | Yamanouchi Pharma Co Ltd | Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient |
EP1424079A1 (en) * | 2002-11-27 | 2004-06-02 | Boehringer Ingelheim International GmbH | Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine |
US9181187B2 (en) | 2007-02-16 | 2015-11-10 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for urinary excretion disorder |
WO2011112499A1 (en) * | 2010-03-08 | 2011-09-15 | Medicinova, Inc. | Compositions, methods, and devices for the treatment of dysmenorrhea |
EP2556049A1 (en) * | 2010-04-08 | 2013-02-13 | MediciNova, Inc. | Methods and compositions for the treatment of irritable bowel syndrome |
US20120309796A1 (en) * | 2011-06-06 | 2012-12-06 | Fariborz Firooznia | Benzocycloheptene acetic acids |
WO2014108449A1 (en) | 2013-01-08 | 2014-07-17 | Atrogi Ab | A screening method, a kit, a method of treatment and a compound for use in a method of treatment |
GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
CN111233820B (zh) * | 2018-11-29 | 2022-11-18 | 睿阜隆(杭州)生物医药有限公司 | 含有冠醚和二(2-甲氧基乙氧基)结构的芬戈莫德衍生物 |
CA3218884A1 (en) * | 2021-05-11 | 2022-11-17 | David Nutt | Therapeutic aminoindane compounds and compositions |
GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL79323A (en) * | 1985-07-10 | 1990-03-19 | Sanofi Sa | Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them |
IT1199339B (it) * | 1986-12-23 | 1988-12-30 | Sigma Tau Ind Farmaceuti | N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono |
FR2643076B1 (fr) * | 1989-02-14 | 1991-06-21 | Midy Spa | Carboxyalkyl-ethers de la 2-amino-7-hydroxytetraline |
EP0499755A1 (fr) * | 1991-02-18 | 1992-08-26 | MIDY S.p.A. | Nouvelles phényléthanolaminotétralines, procédé pour leur préparation, intermédiaires dans ce procédé et compositions pharmaceutiques les contenant |
-
1993
- 1993-01-31 IL IL104567A patent/IL104567A/xx not_active IP Right Cessation
- 1993-02-01 TW TW082100626A patent/TW225513B/zh active
- 1993-02-01 UA UA93003971A patent/UA41869C2/uk unknown
- 1993-02-01 WO PCT/JP1993/000113 patent/WO1993015041A1/en active IP Right Grant
- 1993-02-01 HU HU9303112A patent/HU218941B/hu not_active IP Right Cessation
- 1993-02-01 EP EP93914517A patent/EP0583485B1/en not_active Expired - Lifetime
- 1993-02-01 CA CA002107566A patent/CA2107566A1/en not_active Abandoned
- 1993-02-01 JP JP5513097A patent/JP2819435B2/ja not_active Expired - Fee Related
- 1993-02-01 ES ES93914517T patent/ES2105286T3/es not_active Expired - Lifetime
- 1993-02-01 DK DK93914517.3T patent/DK0583485T3/da active
- 1993-02-01 DE DE69313051T patent/DE69313051T2/de not_active Expired - Fee Related
- 1993-02-01 AU AU33679/93A patent/AU666162B2/en not_active Ceased
- 1993-02-01 AT AT93914517T patent/ATE156804T1/de not_active IP Right Cessation
- 1993-02-01 KR KR1019930702932A patent/KR100250922B1/ko not_active IP Right Cessation
- 1993-02-02 MX MX9300552A patent/MX9300552A/es not_active IP Right Cessation
- 1993-02-02 CN CN93102681A patent/CN1063430C/zh not_active Expired - Fee Related
- 1993-09-17 US US08/117,163 patent/US5387710A/en not_active Expired - Lifetime
-
1997
- 1997-10-21 GR GR970402748T patent/GR3025106T3/el unknown
- 1997-12-03 HK HK97102319A patent/HK1000768A1/xx not_active IP Right Cessation
-
1998
- 1998-05-13 JP JP13016798A patent/JP3282799B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH06506955A (ja) | 1994-08-04 |
JP2819435B2 (ja) | 1998-10-30 |
HUT65351A (en) | 1994-05-02 |
ES2105286T3 (es) | 1997-10-16 |
JP3282799B2 (ja) | 2002-05-20 |
CN1063430C (zh) | 2001-03-21 |
WO1993015041A1 (en) | 1993-08-05 |
DK0583485T3 (da) | 1997-10-06 |
HK1000768A1 (en) | 1998-04-24 |
KR100250922B1 (ko) | 2000-05-01 |
GR3025106T3 (en) | 1998-01-30 |
DE69313051T2 (de) | 1998-01-08 |
TW225513B (uk) | 1994-06-21 |
ATE156804T1 (de) | 1997-08-15 |
EP0583485A1 (en) | 1994-02-23 |
AU3367993A (en) | 1993-09-01 |
IL104567A (en) | 1997-03-18 |
JPH1192432A (ja) | 1999-04-06 |
US5387710A (en) | 1995-02-07 |
IL104567A0 (en) | 1993-05-13 |
CA2107566A1 (en) | 1993-08-04 |
CN1084846A (zh) | 1994-04-06 |
EP0583485B1 (en) | 1997-08-13 |
AU666162B2 (en) | 1996-02-01 |
HU218941B (hu) | 2001-01-29 |
MX9300552A (es) | 1993-09-01 |
HU9303112D0 (en) | 1994-01-28 |
DE69313051D1 (de) | 1997-09-18 |
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